Search Results - "Kurata, T"

Pemetrexed plus platinum with or without pembrolizumab in patients with previously untreated metastatic nonsquamous NSCLC: protocol-specified final analysis from KEYNOTE-189 by Rodríguez-Abreu, D., Powell, S.F., Hochmair, M.J., Gadgeel, S., Esteban, E., Felip, E., Speranza, G., De Angelis, F., Dómine, M., Cheng, S.Y., Bischoff, H.G., Peled, N., Reck, M., Hui, R., Garon, E.B., Boyer, M., Kurata, T., Yang, J., Pietanza, M.C., Souza, F., Garassino, M.C.

“…In the phase III KEYNOTE-189 study (NCT02578680), pembrolizumab plus pemetrexed and platinum-based chemotherapy (pemetrexed–platinum) significantly improved…”
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PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels by Kim, Robin Y., Pless, Stephan A., Kurata, Harley T.

“…Retigabine (RTG) is a first-in-class antiepileptic drug that suppresses neuronal excitability through the activation of voltage-gated KCNQ2–5 potassium…”
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Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations by Baronas, Victoria A., Yang, Runying Y., Morales, Luis Carlos, Sipione, Simonetta, Kurata, Harley T.

“…Kv1.2 is a prominent voltage-gated potassium channel that influences action potential generation and propagation in the central nervous system. We explored…”
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Monitoring of somatic mutations in circulating cell-free DNA by digital PCR and next-generation sequencing during afatinib treatment in patients with lung adenocarcinoma positive for EGFR activating mutations by Iwama, E., Sakai, K., Azuma, K., Harada, T., Harada, D., Nosaki, K., Hotta, K., Ohyanagi, F., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K., Okamoto, I.

“…Analysis of circulating cell-free DNA (cfDNA) is under intensive investigation for its potential to identify tumor somatic mutations. We have now explored the…”
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A structural interpretation of voltage-gated potassium channel inactivation by Kurata, Harley T., Fedida, David

“…After channel activation, and in some cases with sub-threshold depolarizing stimuli, Kv channels undergo a time-dependent loss of conductivity by a family of…”
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Extracellular redox sensitivity of Kv1.2 potassium channels by Baronas, Victoria A., Yang, Runying Y., Kurata, Harley T.

“…Kv1.2 is a prominent potassium channel subtype in the nervous system and serves as an important structural template for investigation of ion channel function…”
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Reducing agents facilitate membrane patch seal integrity and longevity by Das, Damayantee, Wong, Anson, Friedman, Timothy N, Kerr, Bradley J, Kurata, Harley T, Lamothe, Shawn M

“…The patch clamp method is a widely applied electrophysiological technique used to understand ion channel activity and cellular excitation. The formation of a…”
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Identification of EMS-induced causal mutations in a non-reference Arabidopsis thaliana accession by whole genome sequencing by Uchida, Naoyuki, Sakamoto, Tomoaki, Kurata, Tetsuya, Tasaka, Masao

“…The most frequently used method to identify mutations induced by a commonly used mutagen, EMS (ethyl methane sulfonate), in Arabidopsis thaliana has been…”
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Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells by Bruin, Jennifer E., Erener, Suheda, Vela, Javier, Hu, Xiaoke, Johnson, James D., Kurata, Harley T., Lynn, Francis C., Piret, James M., Asadi, Ali, Rezania, Alireza, Kieffer, Timothy J.

“…Human embryonic stem cells (hESCs) were used as a model system of human pancreas development to study characteristics of the polyhormonal cells that arise…”
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Polyamine Transport by the Polyspecific Organic Cation Transporters OCT1, OCT2, and OCT3 by Sala-Rabanal, Monica, Li, Dan C, Dake, Gregory R, Kurata, Harley T, Inyushin, Mikhail, Skatchkov, Serguei N, Nichols, Colin G

“…Polyamines are ubiquitous organic cations implicated in many physiological processes. Because they are positively charged at physiological pH, carrier-mediated…”
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Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels by Lamothe, Shawn M, Sharmin, Nazlee, Silver, Grace, Satou, Motoyasu, Hao, Yubin, Tateno, Toru, Baronas, Victoria A, Kurata, Harley T

“…Many voltage-dependent ion channels are regulated by accessory proteins. We recently reported powerful regulation of Kv1.2 potassium channels by the amino acid…”
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All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition by Kinomoto, Masanobu, Kanno, Takayuki, Shimura, Mari, Ishizaka, Yukihito, Kojima, Asato, Kurata, Takeshi, Sata, Tetsutaro, Tokunaga, Kenzo

“…Approximately 17% of the human genome is comprised of long interspersed nuclear element 1 (LINE-1, L1) non-LTR retrotransposons. L1 retrotransposition is known…”
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KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting by Wrobel, Eva, Rothenberg, Ina, Krisp, Christoph, Hundt, Franziska, Fraenzel, Benjamin, Eckey, Karina, Linders, Joannes T. M., Gallacher, David J., Towart, Rob, Pott, Lutz, Pusch, Michael, Yang, Tao, Roden, Dan M., Kurata, Harley T., Schulze-Bahr, Eric, Strutz-Seebohm, Nathalie, Wolters, Dirk, Seebohm, Guiscard

“…Most small-molecule inhibitors of voltage-gated ion channels display poor subtype specificity because they bind to highly conserved residues located in the…”
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A novel familial prion disease causing pan-autonomic-sensory neuropathy and cognitive impairment by Matsuzono, K., Ikeda, Y., Liu, W., Kurata, T., Deguchi, S., Deguchi, K., Abe, K.

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Osimertinib as first-line (1L) treatment for epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer (NSCLC): Final efficacy and safety results from two phase I expansion cohorts by Yang, J.C.-H., Ramalingam, S.S., Lee, C.K., Kurata, T., Kim, D.-W., John, T., Nogami, N., Ohe, Y., Rukazenkov, Y., Murphy, M., Jänne, P.A.

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Safety and tolerability of pembrolizumab or placebo plus pemetrexed and platinum as first-line therapy in Japanese patients (PTS) with metastatic non-squamous non-small cell lung cancer (NSCLC) enrolled in the phase III KEYNOTE-189 study by Horinouchi, H., Nogami, N., Saka, H., Nishio, M., Tokito, T., Takahashi, T., Kasahara, K., Hattori, Y., Ichihara, E., Adachi, N., Sawada, T., Shimamoto, T., Noguchi, K., Pietanza, M.C., Kurata, T.

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Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels by Pless, Stephan A, Galpin, Jason D, Niciforovic, Ana P, Kurata, Harley T, Ahern, Christopher A

“…Voltage-gated potassium (Kv) channels enable potassium efflux and membrane repolarization in excitable tissues. Many Kv channels undergo a progressive loss of…”
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Swelling and Shrinking Kinetics of Totally Synthetic, Glucose-Responsive Polymer Gel Bearing Phenylborate Derivative as a Glucose-Sensing Moiety by Matsumoto, Akira, Kurata, Takeyuki, Shiino, Daijiro, Kataoka, Kazunori

“…A glucose-responsive polymer gel bead with a diameter in the range of several hundred micrometers, bearing a phenylborate derivative (3-acrylamidophenylboronic…”
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Unusual suspects underlying multimodal gating of Kv1.2 channels by Kurata, Harley T.

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P-034The potential of extravasated platelet aggregation as a surrogate marker for overall survival in patients with advanced gastric cancer treated by preoperative docetaxel, cisplatin, and S-1 by Fushida, S, Saito, H, Kurata, T, Kinoshita, J, Oyama, K, Miyashita, T, Ohta, T

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