Search Results - "Kuras, Zerrin"

KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells by Kuras, Zerrin, Yun, Yeo-Heung, Chimote, Ameet A, Neumeier, Lisa, Conforti, Laura

“…The migration of T lymphocytes is an essential part of the adaptive immune response as T cells circulate around the body to carry out immune surveillance…”
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Inhibitors of potassium channels Kv1.3 and IK-1 as immunosuppressants by PEGORARO, Stefano, LANG, Martin, VISAN, Violeta, GRISSMER, Stephan, DREKER, Tobias, KRAUS, Jürgen, HAMM, Svetlana, MEEREA, Cathal, FEURLE, Juliane, TASLER, Stefan, PRÜTTING, Sylvia, KURAS, Zerrin

“…New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology…”
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Disruption of Kv1.3 Channel Forward Vesicular Trafficking by Hypoxia in Human T Lymphocytes by Chimote, Ameet A., Kuras, Zerrin, Conforti, Laura

“…Hypoxia in solid tumors contributes to decreased immunosurveillance via down-regulation of Kv1.3 channels in T lymphocytes and associated T cell function…”
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Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells by Chimote, Ameet A, Hajdu, Peter, Kucher, Vladimir, Boiko, Nina, Kuras, Zerrin, Szilagyi, Orsolya, Yun, Yeo-Heung, Conforti, Laura

“…Adenosine, a purine nucleoside, is present at high concentrations in tumors, where it contributes to the failure of immune cells to eliminate cancer cells. The…”
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Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex by Kuras, Zerrin, Kucher, Vladimir, Gordon, Scott M, Neumeier, Lisa, Chimote, Ameet A, Filipovich, Alexandra H, Conforti, Laura

“…The cAMP/PKA signaling system constitutes an inhibitory pathway in T cells and, although its biochemistry has been thoroughly investigated, its possible…”
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Adenosine inhibits human T lymphocyte migration via inhibition of KCa3.1 channels by Chimote, Ameet Ajit, Kucher, Vladimir, Boiko, Nina, Hajdu, Peter, Kuras, Zerrin, Yun, Yeo‐Heung, Szilagyi, Orsolya, Conforti, Laura

“…Abstract only Adenosine (Ado), a purine nucleoside, is present at high concentrations in tumors where it contributes to the failure of immune cells to fight…”
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Selective downregulation of human Kv1.3 channels by PKA I by Kuras, Zerrin, Kucher, Vladimir, Neumeier, Lisa, Dillehay, Kelsey, Conforti, Laura

“…The voltage‐gated K channel Kv1.3 plays an important role in the earliest stages of T cell activation and its inhibition suppresses T cell function. Protein…”
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Erratum to “Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants” [Bioorg. Med. Chem. Lett. 19 (2009) 2299–2304] by Pegoraro, Stefano, Lang, Martin, Dreker, Tobias, Kraus, Jürgen, Hamm, Svetlana, Meere, Cathal, Feurle, Juliane, Tasler, Stefan, Prütting, Sylvia, Kuras, Zerrin, Visan, Violeta, Grissmer, Stephan

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Inhibitors of potassium channels K V1.3 and IK-1 as immunosuppressants by Pegoraro, Stefano, Lang, Martin, Dreker, Tobias, Kraus, Jürgen, Hamm, Svetlana, Meere, Cathal, Feurle, Juliane, Tasler, Stefan, Prütting, Sylvia, Kuras, Zerrin, Visan, Violeta, Grissmer, Stephan

“…Applying vHTS based on a homology model, potent inhibitors of K V1.3 and IK-1 were identified. New structural classes of K V1.3 and IK-1 ion channel blockers…”
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