Search Results - "Kurahashi, Masaaki"

A functional role for the ‘fibroblast‐like cells’ in gastrointestinal smooth muscles by Kurahashi, Masaaki, Zheng, Haifeng, Dwyer, Laura, Ward, Sean M., Don Koh, Sang, Sanders, Kenton M.

“…Non‐technical summary Smooth muscles, as in the gastrointestinal tract, are composed of several types of cells. Gastrointestinal muscles contain smooth muscle…”
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A novel postsynaptic signal pathway of sympathetic neural regulation of murine colonic motility by Kurahashi, Masaaki, Kito, Yoshihiko, Baker, Salah A., Jennings, Libby K., Dowers, James G. R., Koh, Sang Don, Sanders, Kenton M.

“…Transcriptome data revealed α1 adrenoceptors (ARs) expression in platelet‐derived growth factor receptor α+ cells (PDGFRα+ cells) in murine colonic…”
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Transcriptome profiling of subepithelial PDGFRα cells in colonic mucosa reveals several cell-selective markers by Ha, Se Eun, Jin, Byungchang, Jorgensen, Brian G, Zogg, Hannah, Wei, Lai, Singh, Rajan, Park, Chanjae, Kurahashi, Masaaki, Kim, Sei, Baek, Gain, Poudrier, Sandra M, Lee, Moon Young, Sanders, Kenton M, Ro, Seungil

“…Subepithelial platelet-derived growth factor receptor alpha (PDGFRα)+ cells found in the colonic mucosal tissue come in close contact with epithelial cells,…”
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Na+-K+-Cl- cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal by Zhu, Mei Hong, Sung, Tae Sik, Kurahashi, Masaaki, O'Kane, Lauren E, O'Driscoll, Kate, Koh, Sang Don, Sanders, Kenton M

“…Interstitial cells of Cajal (ICC) generate electrical slow waves by coordinated openings of ANO1 channels, a Ca -activated Cl (CaCC) conductance. Efflux of Cl…”
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Transcriptome analysis of PDGFRα+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRα+ cell hyperplasia by Ha, Se Eun, Lee, Moon Young, Kurahashi, Masaaki, Wei, Lai, Jorgensen, Brian G, Park, Chanjae, Park, Paul J, Redelman, Doug, Sasse, Kent C, Becker, Laren S, Sanders, Kenton M, Ro, Seungil

“…Platelet-derived growth factor receptor alpha (PDGFRα)+ cells are distributed into distinct morphological groups within the serosal, muscular, and submucosal…”
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Uridine adenosine tetraphosphate is a novel neurogenic P2Y1 receptor activator in the gut by Durnin, Leonie, Hwang, Sung Jin, Kurahashi, Masaaki, Drumm, Bernard T., Ward, Sean M., Sasse, Kent C., Sanders, Kenton M., Mutafova-Yambolieva, Violeta N.

“…Significance Millions of people suffer of gastrointestinal (GI) motility disorders. P2Y1 purine receptors and Ca ²⁺-activated small-conductance K ⁺ (SK)…”
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Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRα + Cells Is a New Marker for Inflammatory Bowel Disease by Ha, Se Eun, Jorgensen, Brian G, Wei, Lai, Jin, Byungchang, Kim, Min-Seob, Poudrier, Sandra M, Singh, Rajan, Bartlett, Allison, Zogg, Hannah, Kim, Sei, Baek, Gain, Kurahashi, Masaaki, Lee, Moon-Young, Kim, Yong-Sung, Choi, Suck-Chei, Sasse, Kent C, Rubin, Samuel J S, Gottfried-Blackmore, Andres, Becker, Laren, Habtezion, Aida, Sanders, Kenton M, Ro, Seungil

“…Metalloendopeptidase ADAM-Like Decysin 1 (ADAMDEC1) is an anti-inflammatory peptidase that is almost exclusively expressed in the gastrointestinal (GI) tract…”
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Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors by Kurahashi, Masaaki, Kito, Yoshihiko, Hara, Masayasu, Takeyama, Hiromitsu, Sanders, Kenton M., Hashitani, Hikaru

“…Colonic musculature contain smooth muscle cells (SMC), interstitial cells of Cajal (ICC), and platelet-derived growth factor receptor α+ cells (PDGFRα+ cells),…”
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Spontaneous transient hyperpolarizations in the rabbit small intestine by Kito, Yoshihiko, Kurahashi, Masaaki, Mitsui, Retsu, Ward, Sean M., Sanders, Kenton M.

“…Key points Recently, it was shown that fibroblast‐like cells (FLCs) possess the apparatus to mediate purinergic motor neurotransmission in the gastrointestinal…”
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Relationship between interstitial cells of Cajal, fibroblast-like cells and inhibitory motor nerves in the internal anal sphincter by Cobine, Caroline A, Hennig, Grant W, Kurahashi, Masaaki, Sanders, Kenton M, Ward, Sean M, Keef, Kathleen D

“…Interstitial cells of Cajal (ICC) have been shown to participate in nitrergic neurotransmission in various regions of the gastrointestinal (GI) tract…”
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The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in the mouse embryonic gut by Torihashi, Shigeko, Hattori, Takako, Hasegawa, Hirotaka, Kurahashi, Masaaki, Ogaeri, Takunori, Fujimoto, Toyoshi

“…Bone morphogenetic protein (BMP) signaling is essential for normal development of the gastrointestinal (GI) tract. BMPs also play multiple roles in vascular…”
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Gut‐Like Structures from Mouse Embryonic Stem Cells as an In Vitro Model for Gut Organogenesis Preserving Developmental Potential After Transplantation by Torihashi, Shigeko, Kuwahara, Masaki, Ogaeri, Takunori, Zhu, Pu, Kurahashi, Masaaki, Fujimoto, Toyoshi

“…Recently, we reported the formation of gut‐like structures from mouse ESCs in vitro. To determine whether ESCs provide an in vitro model of gastrointestinal…”
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Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles by Kurahashi, Masaaki, Mutafova-Yambolieva, Violeta, Koh, Sang Don, Sanders, Kenton M

“…Enteric inhibitory neurotransmission is an important feature of the neural regulation of gastrointestinal motility. Purinergic neurotransmission, via P2Y1…”
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In vitro developmental model of the gastrointestinal tract from mouse embryonic stem cells by Torihashi, Shigeko, Kuwahara, Masaki, Kurahashi, Masaaki

“…Mouse embryonic stem (ES) cells are pluripotent and retain their potential to form cells, tissues and organs originated from three embryonic germ layers…”
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805: PDGFRα+ INTERSTITIAL CELLS INTEGRATE INHIBITORY INPUTS BY VARIOUS SIGNALS TO COLONIC MOTILITY OF MOUSE AND HUMAN by Kurahashi, Masaaki, Kito, Yoshihiko, Baker, Sal, Hara, Masayasu, Takeyama, Hiromitsu, Hashitani, Hikaru, Sanders, Kenton M.

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Ca 2+ Signaling Is the Basis for Pacemaker Activity and Neurotransduction in Interstitial Cells of the GI Tract by Sanders, Kenton M, Baker, Salah A, Drumm, Bernard T, Kurahashi, Masaaki

“…Years ago gastrointestinal motility was thought to be due to interactions between enteric nerves and smooth muscle cells (SMCs) in the tunica muscularis. Thus,…”
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Usefulness of Double-Balloon Enteroscopy (DBE) for Diagnosis and Treatment of Small Intestinal Diseases by Ohmiya, Naoki, Taguchi, Ayumu, Mabuchi, Nobuyuki, Ozeki, Masayasu, Kanazawa, Hironobu, Arakawa, Daigo, Hasegawa, Taisaku, Kobayashi, Taku, Kurahashi, Masaaki, Yamada, Masahiro, Nakamura, Masanao, Itoh, Akihiro, Hirooka, Yoshiki, Niwa, Yasumasa, Goto, Hidemi

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Extracellular metabolism of the enteric inhibitory neurotransmitter β‐nicotinamide adenine dinucleotide (β‐NAD) in the murine colon by Durnin, Leonie, Kurahashi, Masaaki, Sanders, Kenton M., Mutafova‐Yambolieva, Violeta N.

“…Key points β‐Nicotinamide adenine dinucleotide (β‐NAD) is a key inhibitory neurotransmitter in the colon. The neuroeffector junction in the gut consists of…”
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Su1306 – A Novel Potent Post-Synaptic Signaling Pathway of Inhibitory Sympathetic Neural Regulation of Murine Colonic Motility Through Adrenergic Receptor α a in Platelet-Derived Growth Factor Receptor α+ Cells (PDGFRα+ Cells) by Kurahashi, Masaaki, Baker, Sal, Kito, Yoshihiko, Don Koh, Sang, Sanders, Kenton M.

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9 NEW INSIGHTS INTO THE ROLE OF α1 ADRENOCEPTORS IN MOUSE AND HUMAN COLONIC MOTILITY – DISCOVERY OF PROMISING TARGETS FOR FUNCTIONAL BOWEL DISORDERS (FBD) by Kurahashi, Masaaki, Kito, Yoshihiko, Baker, Sal, Hara, Masayasu, Takeyama, Hiromitsu, Koh, Sang Don, Hashitani, Hikaru, Sanders, Kenton M.

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