Search Results - "Kuraguchi, Mari"

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints by Koyama, Shohei, Akbay, Esra A., Li, Yvonne Y., Herter-Sprie, Grit S., Buczkowski, Kevin A., Richards, William G., Gandhi, Leena, Redig, Amanda J., Rodig, Scott J., Asahina, Hajime, Jones, Robert E., Kulkarni, Meghana M., Kuraguchi, Mari, Palakurthi, Sangeetha, Fecci, Peter E., Johnson, Bruce E., Janne, Pasi A., Engelman, Jeffrey A., Gangadharan, Sidharta P., Costa, Daniel B., Freeman, Gordon J., Bueno, Raphael, Hodi, F. Stephen, Dranoff, Glenn, Wong, Kwok-Kin, Hammerman, Peter S.

“…Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung…”
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EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd by Haikala, Heidi M, Lopez, Timothy, Köhler, Jens, Eser, Pinar O, Xu, Man, Zeng, Qing, Teceno, Tyler J, Ngo, Kenneth, Zhao, Yutong, Ivanova, Elena V, Bertram, Arrien A, Leeper, Brittaney A, Chambers, Emily S, Adeni, Anika E, Taus, Luke J, Kuraguchi, Mari, Kirschmeier, Paul T, Yu, Channing, Shiose, Yoshinobu, Kamai, Yasuki, Qiu, Yang, Paweletz, Cloud P, Gokhale, Prafulla C, Jänne, Pasi A

“…Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) are the standard-of-care treatment for -mutant non-small cell lung cancers (NSCLC)…”
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Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non-Small Cell Lung Cancer by Ivanova, Elena, Kuraguchi, Mari, Xu, Man, Portell, Andrew J, Taus, Luke, Diala, Irmina, Lalani, Alshad S, Choi, Jihyun, Chambers, Emily S, Li, Shuai, Liu, Shengwu, Chen, Ting, Barbie, Thanh U, Oxnard, Geoffrey R, Haworth, Jacob J, Wong, Kwok-Kin, Dahlberg, Suzanne E, Aref, Amir A, Barbie, David A, Bahcall, Magda, Paweletz, Cloud P, Jänne, Pasi A

“…Evaluating drug responses using primary patient-derived cells represents a potentially rapid and efficient approach to screening for new treatment approaches…”
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Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood by Wang, Xiu-Ping, O'Connell, Daniel J, Lund, Jennifer J, Saadi, Irfan, Kuraguchi, Mari, Turbe-Doan, Annick, Cavallesco, Resy, Kim, Hyunsoo, Park, Peter J, Harada, Hidemitsu, Kucherlapati, Raju, Maas, Richard L

“…The ablation of Apc function or the constitutive activation ofβ -catenin in embryonic mouse oral epithelium results in supernumerary tooth formation, but the…”
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Adenomatous polyposis coli (APC) is required for normal development of skin and thymus by Kuraguchi, Mari, Wang, Xiu-Ping, Bronson, Roderick T, Rothenberg, Rebecca, Ohene-Baah, Nana Yaw, Lund, Jennifer J, Kucherlapati, Melanie, Maas, Richard L, Kucherlapati, Raju

“…The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis…”
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Genetic mechanisms in Apc-mediated mammary tumorigenesis by Kuraguchi, Mari, Ohene-Baah, Nana Yaw, Sonkin, Dmitriy, Bronson, Roderick Terry, Kucherlapati, Raju

“…Many components of Wnt/beta-catenin signaling pathway also play critical roles in mammary tumor development, yet the role of the tumor suppressor gene APC…”
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Haploinsufficiency of Flap Endonuclease (Fen1) Leads to Rapid Tumor Progression by Kucherlapati, Melanie, Yang, Kan, Kuraguchi, Mari, Zhao, Jie, Lia, Maria, Heyer, Joerg, Kane, Michael F., Fan, Kunhua, Russell, Robert, Anthony M. C. Brown, Kneitz, Burkhard, Edelmann, Winfried, Kolodner, Richard D., Lipkin, Martin, Kucherlapati, Raju

“…Flap endonuclease (Fen1) is required for DNA replication and repair, and defects in the gene encoding Fen1 cause increased accumulation of mutations and genome…”
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Mbd4 Inactivation Increases C→T Transition Mutations and Promotes Gastrointestinal Tumor Formation by Wong, Edmund, Yang, Kan, Kuraguchi, Mari, Werling, Uwe, Avdievich, Elena, Fan, Kunhua, Fazzari, Melissa, Jin, Bo, Anthony M.C. Brown, Lipkin, Martin, Edelmann, Winfried

“…Mbd4 (methyl-CpG binding domain 4) is a novel mammalian repair enzyme that has been implicated biochemically in the repair of mismatched G-T residues at…”
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Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression by Chen, Peng-Chieh, Kuraguchi, Mari, Velasquez, John, Wang, Yuxun, Yang, Kan, Edwards, Robert, Gillen, Dan, Edelmann, Winfried, Kucherlapati, Raju, Lipkin, Steven M

“…DNA mismatch repair suppresses gastrointestinal tumorgenesis. Four mammalian E. coli MutL homologues heterodimerize to form three distinct complexes:…”
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Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon by Kucherlapati, Melanie H, Yang, Kan, Fan, Kunhua, Kuraguchi, Mari, Sonkin, Dmitriy, Rosulek, Andrew, Lipkin, Martin, Bronson, Roderick T, Aronow, Bruce J, Kucherlapati, Raju

“…To examine the role of Rb1 in gastrointestinal (GI) tumors, we generated mice with an Apc 1638N allele, Rb tm2brn floxed alleles, and a villin-cre transgene…”
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Abstract 3286: B-hCD94/hNKG2A mice provide a preclinical tool for evaluating therapeutic antibodies targeting human NKG2A by Shang, Chengzhang, He, Fang, Kuraguchi, Mari, Zhang, Jing, Lin, Qingcong

“…Abstract The immune cell checkpoint NKG2A and its coreceptor, CD94, are expressed by many circulating NK cells and by a subset of CD8 T cells in tumors. When…”
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Abstract 3993: In vivo efficacy of an anti-human IL11RA antibody in B-hIL11RA mice with APAP-induced liver damage by He, Fang, Zhang, Rufeng, Kuraguchi, Mari, Zhao, Lei, Yu, Zhaoxue

“…Abstract Acetaminophen (N-acetyl-p-aminophenol; APAP) overdose is a common cause of drug-induced acute liver injury, thereby making APAP administration a…”
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Abstract 113: Generation and validation of a novel humanized IL-31/IL-31RA/OSM/OSMR mouse model by Wang, Linlin, Zhao, Lei, Zhang, Meiqi, Zhang, Zhi, Chen, Zhen, Kuraguchi, Mari, Lian, Jingjing, Zhang, Jiansu

“…Abstract Oncostatin M (OSM) and interleukin-31 (IL-31) are two pleiotropic cytokines that share a common signaling receptor subunit, the OSM receptor beta…”
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Abstract 5339: Establishment of a humanized IL5/IL5RA mouse model to evaluate modulators of eosinophilic inflammation in vivo by Zhao, Suman, Zhang, Shujin, Chen, Zhen, Yang, Liya, Kuraguchi, Mari, Yuan, Jiangfeng, Shen, Heiling

“…Abstract IL-5/IL-5R signaling plays a key role in the maturation, activation, survival, and recruitment of eosinophils to sites of inflammation. Targeting this…”
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Abstract 5346: A novel humanized CD16A model to evaluate efficacy of human antibody therapeutics in triggering ADCC by Liu, Xiao, Niu, Zhenlan, Lv, Ruili, Lin, Qingcong, Kuraguchi, Mari, Xu, Qingqing

“…Abstract Antibody-dependent cellular cytotoxicity (ADCC) is a mechanism by which immune effector cells engage the Fc portion of antibodies bound to antigen on…”
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Abstract 2089: Evaluating in vivo efficacy of anti-TSLP antibodies in humanized B-hTSLP/hTSLPR mice by Zhang, Shujin, Nie, Yanhui, Chang, Jiahui, Chromikova, Veronika, Yu, Luke (Zhaoxue), Kuraguchi, Mari

“…Abstract Expression of the epithelial cytokine, thymic stromal lymphopoietin (TSLP), has been observed across several barrier surfaces and plays a critical…”
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Abstract 1643: B-hIL12A/hIL12B/hIL12RB1/hIL12RB2: A novel animal model for generation of IL12 therapies by Wang, Linlin, Liu, Chang, Chromikova, Veronika, Lyu, Ruili, Jin, Tianquan, Kuraguchi, Mari

“…Abstract The pro-inflammatory cytokine, interleukin 12 (IL12), is primarily responsible for cell-mediated immunity and is chiefly produced by antigen…”
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Abstract 4806: Exploring optimal targeted combination therapies with neratinib for HER2 mutated NSCLC by Kuraguchi, Mari, Taus, Luke J., Zhou, Shan, Avogadri-Connors, Francesca, Cutler, Richard E., Lalani, Alshad S., Kirschmeier, Paul, Jänne, Pasi A.

“…Abstract Genetic alterations which constitutively activate human epidermal growth factor receptor 2 (HER2; ERBB2) without overexpression have been observed in…”
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Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency by Kuraguchi, M, Edelmann, W, Yang, K, Lipkin, M, Kucherlapati, R, Brown, A M

“…Apc1638N mice, which are heterozygous for a germline mutation in Apc, typically develop three to five spontaneous intestinal tumors per animal. In most cases…”
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Abstract 4778: Assessing efficacy of neratinib in HER2-driven lung cancer by Li, Shuai, Liu, Shengwu, Chen, Ting, Deng, Jiehui, Wu, Min, Kuraguchi, Mari, Tran, Cam Anh, Kirschmeier, Paul T., Avogadri-Connors, Francesca, Cutler, Richard E., Lalani, Alshad S., Wong, Kwok-Kin

“…Abstract HER2 mutations have been classified as oncogenic drivers that are present in 2-4% of lung adenocarcinomas. However, due to limited preclinical studies…”
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