Search Results - "Kuppen, Peter Jk"

Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer by Mieog, J Sven D, de Kruijf, Esther M, Bastiaannet, Esther, Kuppen, Peter Jk, Sajet, Anita, de Craen, Anton Jm, Smit, Vincent Thbm, van de Velde, Cornelis Jh, Liefers, Gerrit-Jan

“…The purpose of this study was to compare the expression and the prognostic effect of the breast cancer stem cell marker aldehyde dehydrogenase-1 (ALDH1) in…”
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Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry by Trinh, Anne, Trumpi, Kari, De Sousa E Melo, Felipe, Wang, Xin, de Jong, Joan H, Fessler, Evelyn, Kuppen, Peter J K, Reimers, Marlies S, Swets, Marloes, Koopman, Miriam, Nagtegaal, Iris D, Jansen, Marnix, Hooijer, Gerrit K J, Offerhaus, George J A, Kranenburg, Onno, Punt, Cornelis J, Medema, Jan Paul, Markowetz, Florian, Vermeulen, Louis

“…Recent transcriptomic analyses have identified four distinct molecular subtypes of colorectal cancer with evident clinical relevance. However, the requirement…”
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Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells by de Geus, Susanna WL, Baart, Victor M, Boonstra, Martin C, Kuppen, Peter JK, Prevoo, Hendrica AJM, Mazar, Andrew P, Bonsing, Bert A, Morreau, Hans, van de Velde, Cornelis JH, Vahrmeijer, Alexander L, Sier, Cornelis FM

“…The urokinase plasminogen activator receptor (uPAR) has been proposed as a potential prognostic factor for various malignancies. The aim of this study is to…”
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NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study by de Kruijf, Esther M, Sajet, Anita, van Nes, Johanna G H, Putter, Hein, Smit, Vincent T H B M, Eagle, Robert A, Jafferji, Insiya, Trowsdale, John, Liefers, Gerrit Jan, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Cell surface NKG2D ligands (NKG2DL) bind to the activating NKG2D receptor present on NK cells and subsets of T cells, thus playing a role in initiating an…”
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Prognostic value of HLA class I, HLA-E, HLA-G and Tregs in rectal cancer: a retrospective cohort study by Reimers, Marlies S, Engels, Charla C, Putter, Hein, Morreau, Hans, Liefers, Gerrit Jan, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Evasion of immune surveillance and suppression of the immune system are important hallmarks of tumorigenesis. The goal of this study was to establish distinct…”
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Cytoplasmic Overexpression of HER2: a Key Factor in Colorectal Cancer by Blok, Erik J, Kuppen, Peter JK, van Leeuwen, Jeroen EM, Sier, Cornelis FM

“…Trastuzumab, a humanized mouse monoclonal antibody directed against HER2 (Human Epidermal Growth Factor Receptor 2), is currently a keystone in the treatment…”
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Copy number alterations and allelic ratio in relation to recurrence of rectal cancer by Goossens-Beumer, Inès J, Oosting, Jan, Corver, Wim E, Janssen, Marjolein J F W, Janssen, Bart, van Workum, Wilbert, Zeestraten, Eliane C M, van de Velde, Cornelis J H, Morreau, Hans, Kuppen, Peter J K, van Wezel, Tom

“…In rectal cancer, total mesorectal excision surgery combined with preoperative (chemo)radiotherapy reduces local recurrence rates but does not improve overall…”
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High-resolution MALDI-FT-ICR MS imaging for the analysis of metabolites from formalin-fixed, paraffin-embedded clinical tissue samples by Buck, Achim, Ly, Alice, Balluff, Benjamin, Sun, Na, Gorzolka, Karin, Feuchtinger, Annette, Janssen, Klaus-Peter, Kuppen, Peter JK, van de Velde, Cornelis JH, Weirich, Gregor, Erlmeier, Franziska, Langer, Rupert, Aubele, Michaela, Zitzelsberger, Horst, Aichler, Michaela, Walch, Axel

“…We present the first analytical approach to demonstrate the in situ imaging of metabolites from formalin‐fixed, paraffin‐embedded (FFPE) human tissue samples…”
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HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients by de Kruijf, Esther M, Sajet, Anita, van Nes, Johanna G H, Natanov, Russ, Putter, Hein, Smit, Vincent T H B M, Liefers, Gerrit Jan, van den Elsen, Peter J, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Nonclassical HLAs, HLA-E and HLA-G, are known to affect clinical outcome in various tumor types. We examined the clinical impact of HLA-E and HLA-G expression…”
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Histone trimethylation at H3K4, H3K9 and H4K20 correlates with patient survival and tumor recurrence in early-stage colon cancer by Benard, Anne, Goossens-Beumer, Inès J, van Hoesel, Anneke Q, de Graaf, Wouter, Horati, Hamed, Putter, Hein, Zeestraten, Eliane C M, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Post-translational modification of histone tails by methylation plays an important role in tumorigenesis. In this study, we investigated the nuclear expression…”
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CD163 as a Biomarker in Colorectal Cancer: The Expression on Circulating Monocytes and Tumor-Associated Macrophages, and the Soluble Form in the Blood by Krijgsman, Daniëlle, De Vries, Natasja L, Andersen, Morten N, Skovbo, Anni, Tollenaar, Rob A E M, Møller, Holger J, Hokland, Marianne, Kuppen, Peter J K

“…The macrophage-associated molecule CD163 has been reported as a prognostic biomarker in different cancer types, but its role in colorectal cancer (CRC) is…”
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A multimodal molecular imaging approach targeting urokinase plasminogen activator receptor for the diagnosis, resection and surveillance of urothelial cell carcinoma by Baart, Victor M., van der Horst, Geertje, Deken, Marion M., Bhairosingh, Shadhvi S., Schomann, Timo, Sier, Vincent Q., van der Mark, Maaike H., Iamele, Luisa, de Jonge, Hugo, Resnati, Massimo, Mazar, Andrew P., Pelger, Rob C.M., van der Pluijm, Gabriel, Kuppen, Peter J.K., Vahrmeijer, Alexander L., Sier, Cornelis F.M.

“…With a 5-year recurrence rate of 30–78%, urothelial cell carcinoma (UCC) rates amongst the highest of all solid malignancies. Consequently, after transurethral…”
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The prognostic value of tumor–stroma ratio in tumor‐positive axillary lymph nodes of breast cancer patients by Vangangelt, Kiki M.H., Tollenaar, Lisanne S.A., van Pelt, Gabi W., de Kruijf, Esther M., Dekker, Tim J.A., Kuppen, Peter J.K., Tollenaar, Rob A.E.M., Mesker, Wilma E.

“…The tumor–stroma ratio (TSR) has previously been found to be a strong prognostic parameter in primary breast cancer tumors. Since the presence of tumor cells…”
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Preclinical evaluation of a novel CEA‐targeting near‐infrared fluorescent tracer delineating colorectal and pancreatic tumors by Boonstra, Martin C., Tolner, Berend, Schaafsma, Boudewijn E., Boogerd, Leonora S.F., Prevoo, Hendrica A.J.M, Bhavsar, Guarav, Kuppen, Peter J.K., Sier, Cornelis F.M., Bonsing, Bert A., Frangioni, John V., van de Velde, Cornelis J.H., Chester, Kerry A., Vahrmeijer, Alexander L.

“…Surgery is the cornerstone of oncologic therapy with curative intent. However, identification of tumor cells in the resection margins is difficult, resulting…”
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High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients by Derr, Remco S, van Hoesel, Anneke Q, Benard, Anne, Goossens-Beumer, Inès J, Sajet, Anita, Dekker-Ensink, N Geeske, de Kruijf, Esther M, Bastiaannet, Esther, Smit, Vincent T H B M, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Breast cancer is a heterogeneous disease with a highly variable clinical outcome in which both genetic and epigenetic changes have critical roles. We…”
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The CpG island methylator phenotype (CIMP) in colorectal cancer by Nazemalhosseini Mojarad, Ehsan, Kuppen, Peter Jk, Aghdaei, Hamid Asadzadeh, Zali, Mohammad Reza

“…It is clear that colorectal cancer (CRC) develops through multiple genetic and epigenetic pathways. These pathways may be determined on the basis of three…”
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The prognostic value of the immune profile of breast cancer stage I in Russian and Dutch women by Kolyadina, Irina Vladimirovna, Poddubnaya, Irina, Van De Velde, Cornelis J. H., Kuppen, Peter JK, Bastiaannet, Esther, Davydov, Mikhail, Komov, Dmitrii, Frank, Georgii

“…Abstract only…”
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HLA-G and classical HLA class I expression in primary colorectal cancer and associated liver metastases by Swets, Marloes, König, Marion H, Zaalberg, Anniek, Dekker-Ensink, Neeltje G, Gelderblom, Hans, van de Velde, Cornelis J.H, van den Elsen, Peter J, Kuppen, Peter J.K

“…Abstract De novo expression of HLA-G has been demonstrated in colorectal cancer. HLA-G, amongst others, inhibits natural killer cell function, contributing to…”
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Selecting Tumor-Specific Molecular Targets in Pancreatic Adenocarcinoma: Paving the Way for Image-Guided Pancreatic Surgery by de Geus, Susanna W. L., Boogerd, Leonora S. F., Swijnenburg, Rutger-Jan, Mieog, J. Sven D., Tummers, Willemieke S. F. J., Prevoo, Hendrica A. J. M., Sier, Cornelis F. M., Morreau, Hans, Bonsing, Bert A., van de Velde, Cornelis J. H., Vahrmeijer, Alexander L., Kuppen, Peter J. K.

“…Purpose The purpose of this study was to identify suitable molecular targets for tumor-specific imaging of pancreatic adenocarcinoma. Procedures The expression…”
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The Influence of BRAF and KRAS Mutation Status on the Association between Aspirin Use and Survival after Colon Cancer Diagnosis by Frouws, Martine A, Reimers, Marlies S, Swets, Marloes, Bastiaannet, Esther, Prinse, Bianca, van Eijk, Ronald, Lemmens, Valery E P P, van Herk-Sukel, Myrthe P P, van Wezel, Tom, Kuppen, Peter J K, Morreau, Hans, van de Velde, Cornelis J H, Liefers, Gerrit-Jan

“…Use of aspirin after diagnosis of colon cancer has been associated with improved survival. Identification of cancer subtypes that respond to aspirin treatment…”
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