Search Results - "Kuppen, Peter J.K"

TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis by Zhang, Long, Zhou, Fangfang, García de Vinuesa, Amaya, de Kruijf, Esther M., Mesker, Wilma E., Hui, Li, Drabsch, Yvette, Li, Yihao, Bauer, Andreas, Rousseau, Adrien, Sheppard, Kelly-Ann, Mickanin, Craig, Kuppen, Peter J.K., Lu, Chris X., ten Dijke, Peter

“…TGF-β signaling is a therapeutic target in advanced cancers. We identified tumor necrosis factor receptor-associated factor 4 (TRAF4) as a key component…”
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Statin Use After Diagnosis of Colon Cancer and Patient Survival by Voorneveld, Philip W., MD, Reimers, Marlies S., MD PhD, Bastiaannet, Esther, PhD, Jacobs, Rutger J., MD, PhD, van Eijk, Ronald, PhD, Zanders, Marjolein M.J., MD, Herings, Ron M.C., PhD, van Herk-Sukel, Myrthe P.P., PhD, Kodach, Liudmila L., MD, PhD, van Wezel, Tom, PhD, Kuppen, Peter J.K., PhD, Morreau, Hans, MD, PhD, van de Velde, Cornelis J.H., MD, PhD, Hardwick, James C.H., MD, PhD, Liefers, Gerrit Jan, MD, PhD

“…Abstract Background & Aims Statin use has been associated with a reduced incidence of colorectal cancer, and might also affect survival of patients diagnosed…”
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Clinical applications of the urokinase receptor (uPAR) for cancer patients by Boonstra, Martin C, Verspaget, Hein W, Ganesh, Sjam, Kubben, Frank J G M, Vahrmeijer, Alexander L, van de Velde, Cornelis J H, Kuppen, Peter J K, Quax, Paul H A, Sier, Cornelis F M

“…Since decades the urokinase plasminogen activator (uPA) system has been associated with the invasion of malignant cells. The receptor of urokinase (uPAR) is…”
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A method for semi-automated image analysis of HLA class I tumour epithelium expression in rectal cancer by Krijgsman, Daniëlle, Van Vlierberghe, Ronald L P, Evangelou, Vaios, Vahrmeijer, Alexander L, Van de Velde, Cornelis J H, Sier, Cornelis F M, Kuppen, Peter J K

“…Biomarkers may hold the key towards development and improvement of personalized cancer treatment. For instance, tumour expression of immune system-related…”
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Near-Infrared Fluorescence Imaging of Liver Metastases in Rats using Indocyanine Green by van der Vorst, Joost R., M.D, Hutteman, Merlijn, M.Sc, Mieog, J. Sven D., M.D, de Rooij, Karien E., Ph.D, Kaijzel, Eric L., Ph.D, Löwik, Clemens W.G.M., Ph.D, Putter, Hein, Ph.D, Kuppen, Peter J.K., Ph.D, Frangioni, John V., M.D., Ph.D, van de Velde, Cornelis J.H., M.D., Ph.D, Vahrmeijer, Alexander L., M.D., Ph.D

“…Background Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) is a promising technique to obtain real-time assessment of the extent and…”
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High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue by Ly, Alice, Buck, Achim, Balluff, Benjamin, Sun, Na, Gorzolka, Karin, Feuchtinger, Annette, Janssen, Klaus-Peter, Kuppen, Peter J K, van de Velde, Cornelis J H, Weirich, Gregor, Erlmeier, Franziska, Langer, Rupert, Aubele, Michaela, Zitzelsberger, Horst, McDonnell, Liam, Aichler, Michaela, Walch, Axel

“…Formalin-fixed paraffin embedding (FFPE) of tissues has been assumed to alter the metabolite content or chemical state, hampering metabolomics studies. Here,…”
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The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery by Schaafsma, Boudewijn E., Mieog, J. Sven D., Hutteman, Merlijn, van der Vorst, Joost R., Kuppen, Peter J.K., Löwik, Clemens W.G.M., Frangioni, John V., van de Velde, Cornelis J.H., Vahrmeijer, Alexander L.

“…Optical imaging using near‐infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence…”
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Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry by Trinh, Anne, Trumpi, Kari, De Sousa E Melo, Felipe, Wang, Xin, de Jong, Joan H, Fessler, Evelyn, Kuppen, Peter J K, Reimers, Marlies S, Swets, Marloes, Koopman, Miriam, Nagtegaal, Iris D, Jansen, Marnix, Hooijer, Gerrit K J, Offerhaus, George J A, Kranenburg, Onno, Punt, Cornelis J, Medema, Jan Paul, Markowetz, Florian, Vermeulen, Louis

“…Recent transcriptomic analyses have identified four distinct molecular subtypes of colorectal cancer with evident clinical relevance. However, the requirement…”
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Estrogen Receptor Pathway Activity Score to Predict Clinical Response or Resistance to Neoadjuvant Endocrine Therapy in Primary Breast Cancer by Inda, Márcia A, Blok, Erik J, Kuppen, Peter J K, Charehbili, Ayoub, den Biezen-Timmermans, Eveline C, van Brussel, Anne, Fruytier, Sevgi E, Meershoek-Klein Kranenbarg, Elma, Kloet, Susan, van der Burg, Bart, Martens, John W M, Sims, Andrew H, Turnbull, Arran K, Dixon, J Michael, Verhaegh, Wim, Kroep, Judith R, van de Velde, Cornelis J H, van de Stolpe, Anja

“…Endocrine therapy is important for management of patients with estrogen receptor (ER)-positive breast cancer; however, positive ER staining does not reliably…”
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Tumor–stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients by de Kruijf, Esther M., van Nes, Johanna G. H., van de Velde, Cornelis J. H., Putter, Hein, Smit, Vincent T. H. B. M., Liefers, Gerrit Jan, Kuppen, Peter J. K., Tollenaar, Rob A. E. M., Mesker, Wilma E.

“…Stroma tissue surrounding cancer cells plays an important role in tumor development and behavior. In colorectal cancer, it has been found that the amount of…”
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CD163 as a Biomarker in Colorectal Cancer: The Expression on Circulating Monocytes and Tumor-Associated Macrophages, and the Soluble Form in the Blood by Krijgsman, Daniëlle, De Vries, Natasja L, Andersen, Morten N, Skovbo, Anni, Tollenaar, Rob A E M, Møller, Holger J, Hokland, Marianne, Kuppen, Peter J K

“…The macrophage-associated molecule CD163 has been reported as a prognostic biomarker in different cancer types, but its role in colorectal cancer (CRC) is…”
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The prognostic value of tumor–stroma ratio in tumor‐positive axillary lymph nodes of breast cancer patients by Vangangelt, Kiki M.H., Tollenaar, Lisanne S.A., van Pelt, Gabi W., de Kruijf, Esther M., Dekker, Tim J.A., Kuppen, Peter J.K., Tollenaar, Rob A.E.M., Mesker, Wilma E.

“…The tumor–stroma ratio (TSR) has previously been found to be a strong prognostic parameter in primary breast cancer tumors. Since the presence of tumor cells…”
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HLA-G and classical HLA class I expression in primary colorectal cancer and associated liver metastases by Swets, Marloes, König, Marion H, Zaalberg, Anniek, Dekker-Ensink, Neeltje G, Gelderblom, Hans, van de Velde, Cornelis J.H, van den Elsen, Peter J, Kuppen, Peter J.K

“…Abstract De novo expression of HLA-G has been demonstrated in colorectal cancer. HLA-G, amongst others, inhibits natural killer cell function, contributing to…”
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Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation by Hoekstra, Elmer, Das, Asha M, Willemsen, Marcella, Swets, Marloes, Kuppen, Peter J K, van der Woude, Christien J, Bruno, Marco J, Shah, Jigisha P, Ten Hagen, Timo L M, Chisholm, John D, Kerr, William G, Peppelenbosch, Maikel P, Fuhler, Gwenny M

“…Colorectal cancer (CRC) is the second most common cause of cancer-related death, encouraging the search for novel therapeutic targets affecting tumor cell…”
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Noninvasive Detection of Metastases and Follicle Density in Ovarian Tissue Using Full-Field Optical Coherence Tomography by Peters, Inge T A, Stegehuis, Paulien L, Peek, Ronald, Boer, Florine L, van Zwet, Erik W, Eggermont, Jeroen, Westphal, Johan R, Kuppen, Peter J K, Trimbos, J Baptist, Hilders, Carina G J M, Lelieveldt, Boudewijn P F, van de Velde, Cornelis J H, Bosse, Tjalling, Dijkstra, Jouke, Vahrmeijer, Alexander L

“…Autotransplantation of ovarian tissue can be used to restore fertility in patients with cancer following gonadotoxic treatment. Whether this procedure is safe…”
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Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer by SPEETJENS, Frank M, KUPPEN, PeterJ. K, DRIJFHOUT, Jan W, VAN DE VELDE, Cornelis J. H, MELIEF, Cornelis J. M, VAN DER BURG, Sjoerd H, WELTERS, MarijJ. P, ESSAHSAH, Farah, VOET VAN DEN BRINK, Anne Marie E. G, KALLENBERG LANTRUA, M. Graziella, VALENTIJN, A. Rob P. M, OOSTENDORP, Jaap, FATHERS, Lorraine M, NIJMAN, Hans W

“…Purpose: The tumor-associated self-antigen p53 is commonly overexpressed in cancer, including colorectal cancer, and can serve as a target for immunotherapy…”
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The Predictive Value of HLA Class I Tumor Cell Expression and Presence of Intratumoral Tregs for Chemotherapy in Patients with Early Breast Cancer by DE KRUIJF, Esther M, VAN NES, Johanna G. H, KUPPEN, Peter J. K, SAJET, Anita, TUMMERS, Quirijn R. J. G, PUTTER, Hein, OSANTO, Susanne, SPEETJENS, Frank M, SMIT, Vincent T. H. B. M, JAN LIEFERS, Gerrit, VAN DE VELDE, Cornelis J. H

“…Purpose: We hypothesized that T-cell immune interaction affects tumor development and thus clinical outcome. Therefore, we examined the clinical impact of…”
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MicroRNA classifier and nomogram for metastasis prediction in colon cancer by Goossens-Beumer, Inès J, Derr, Remco S, Buermans, Henk P J, Goeman, Jelle J, Böhringer, Stefan, Morreau, Hans, Nitsche, Ulrich, Janssen, Klaus-Peter, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Colon cancer prognosis and treatment are currently based on a classification system still showing large heterogeneity in clinical outcome, especially in TNM…”
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Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor–positive early breast cancer patients by van Nes, Johanna G. H., de Kruijf, Esther M., Putter, Hein, Faratian, Dana, Munro, Alison, Campbell, Fiona, Smit, Vincent T. H. B. M., Liefers, Gerrit-Jan, Kuppen, Peter J. K., van de Velde, Cornelis J. H., Bartlett, John M. S.

“…Epithelial mesenchymal transition (EMT) plays an important role in the development of metastases. One of the hallmarks of EMT is loss of E-cadherin and gain of…”
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Low Level of Microsatellite Instability Correlates with Poor Clinical Prognosis in Stage II Colorectal Cancer Patients by Kuppen, Peter J. K., Zali, Mohammad Reza, Asadzadeh Aghdaei, Hamid, Pourhoseingholi, Mohammad Amin, Savabkar, Sanaz, Azimzadeh, Pedram, Taleghani, Mohammad Yaghoob, Mirtalebi, Hanieh, Kashfi, Seyed Mohammad Hossein, Mojarad, Ehsan Nazemalhosseini, Jalaeikhoo, Hasan

“…The influence of microsatellite instability (MSI) on the prognosis of colorectal cancer (CRC) requires more investigation. We assessed the role of MSI status…”
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