Search Results - "Kuphal, S"

Wild-type KRAS is a novel therapeutic target for melanoma contributing to primary and acquired resistance to BRAF inhibition by Dietrich, P, Kuphal, S, Spruss, T, Hellerbrand, C, Bosserhoff, A K

“…Malignant melanoma reveals rapidly increasing incidence and mortality rates worldwide. By now, BRAF inhibition is the standard therapy for advanced melanoma in…”
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Influence of the cytoplasmic domain of E-cadherin on endogenous N-cadherin expression in malignant melanoma by KUPHAL, S, BOSSERHOFF, A. K

“…E-cadherin is known to be an important molecule in epithelial-mesenchymal transition (EMT). Malignant transformation of melanocytes frequently attends with…”
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Expression of Dickkopf genes is strongly reduced in malignant melanoma by KUPHAL, S, LODERMEYER, S, BATAILLE, F, SCHUIERER, M, HOANG, B. H, BOSSERHOFF, A. K

“…The Dickkopf (DKK) genes were originally identified as factors inducing head formation in Xenopus. The genes code for inhibitors that are involved in Wnt…”
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MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression by Kappelmann, M, Kuphal, S, Meister, G, Vardimon, L, Bosserhoff, A-K

“…A fundamental event in the development and progression of malignant melanoma is the deregulation of cancer-relevant transcription factors. We recently showed…”
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Expression of Hugl-1 is strongly reduced in malignant melanoma by Kuphal, S, Wallner, S, Schimanski, C C, Bataille, F, Hofer, P, Strand, S, Strand, D, Bosserhoff, A K

“…The human gene Hugl-1 (Llgl/Lgl1) has significant homology to the Drosophila tumor suppressor gene lethal(2)giant larvae (lgl). The lgl gene codes for a…”
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Post-transcriptional regulation controlled by E-cadherin is important for c-Jun activity in melanoma by Spangler, B., Vardimon, L., Bosserhoff, A. K., Kuphal, S.

“…Summary A central event in the development of malignant melanoma is the loss of the tumor‐suppressor protein E‐cadherin. Here, we report that this loss is…”
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GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma by Kuphal, S, Shaw-Hallgren, G, Eberl, M, Karrer, S, Aberger, F, Bosserhoff, A K, Massoumi, R

“…CYLD is a deubiquitination enzyme that regulates different cellular processes, such as cell proliferation and cell survival. Mutation and loss of…”
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Loss of E-cadherin leads to upregulation of NFκB activity in malignant melanoma by KUPHAL, S, POSER, I, JOBIN, C, HELLERBRAND, C, BOSSERHOFF, A. K

“…Malignant transformation of melanocytes frequently coincides with loss of E-cadherin expression. Here, we show that loss of E-cadherin leads to induction of…”
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Isolation of high quality protein samples from punches of formalin fixed and paraffin embedded tissue blocks by Kroll, J, Becker, K F, Kuphal, S, Hein, R, Hofstädter, F, Bosserhoff, A K

“…In general, it is believed that the extraction of proteins from formalin-fixed paraffin embedded samples is not feasible. However, recently a new technique was…”
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Multicentre study on standardisation of melanoma cell culture - an initiative of the German Melanoma Research Network by Eberle, J., Spangler, B., Becker, J. C., Heinemann, S. H., Klein, C. A., Kunz, M., Kuphal, S., Langer, P., Mauch, C., Meierjohann, S., Paschen, A., Schadendorf, D., Schartl, M., Schittek, B., Schönherr, R., Tüting, T., Zigrino, P., Bosserhoff, A. K.

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Integrin signaling in malignant melanoma by Kuphal, Silke, Bauer, Richard, Bosserhoff, Anja-Katrin

“…Cell adhesion and migration are essential for embryonic development, tissue regeneration, but also for tumor development. The physical link between the…”
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A single flavoprotein, AppA, integrates both redox and light signals in Rhodobacter sphaeroides by Braatsch, Stephan, Gomelsky, Mark, Kuphal, Silke, Klug, Gabriele

“…Summary Anoxygenic photosynthetic proteobacteria exhibit various light responses, including changing levels of expression of photosynthesis genes. However, the…”
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Search for molecular modulators of beta-catenin activity in malignant melanoma by Kuphal, S., Bosserhoff, A.

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Snail-regulated genes in malignant melanoma by Kuphal, Silke, Palm, Hans G, Poser, Ina, Bosserhoff, Anja K

“…The demonstration that zinc-finger transcriptional repressors can control E-cadherin expression in epithelial cells has provided a new avenue of research in…”
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Functional role of MIA in melanocytes and early development of melanoma by POSER, Ina, TATZEL, Jutta, KUPHAL, Silke, BOSSERHOFF, Anja K

“…The protein MIA (melanoma inhibitory activity) is highly expressed in malignant melanomas but not in melanocytes. Furthermore, expression of MIA correlates…”
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Multicentre study on standardisation of melanoma cell culture - an initiative of the German Melanoma Research Network: Letter to the Editor by Eberle, J., Spangler, B., Becker, J. C., Heinemann, S. H., Klein, C. A., Kunz, M., Kuphal, S., Langer, P., Mauch, C., Meierjohann, S., Paschen, A., Schadendorf, D., Schartl, M., Schittek, B., Schönherr, R., Tüting, T., Zigrino, P., Bosserhoff, A. K.

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Loss of E-cadherin leads to upregulation of NFkappaB activity in malignant melanoma by Kuphal, S, Poser, I, Jobin, C, Hellerbrand, C, Bosserhoff, A K

“…Malignant transformation of melanocytes frequently coincides with loss of E-cadherin expression. Here, we show that loss of E-cadherin leads to induction of…”
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Loss of E-cadherin leads to upregulation of NF B activity in malignant melanoma by Kuphal, S, Poser, I, Jobin, C, Hellerbrand, C, Bosserhoff, A K

“…Malignant transformation of melanocytes frequently coincides with loss of E-cadherin expression. Here, we show that loss of E-cadherin leads to induction of…”
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Persistent NFkappaB activation in malignant melanoma is generated through loss of the tumor suppressor CYLD by Kuphal, S., Massoumi, Ramin, Haas, B., Wild, P., Pfeifer, A., Bosserhoff, A.

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Persistent NFkappaB activation in malignant melanoma is generated through loss of the tumor suppressor CYLD by Kuphal, S., Massoumi, Ramin, Haas, B., Wild, P. J., Spruss, T., Pfeifer, A., Bosserhoff, A. K.

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