Search Results - "Kupatt, C."

Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner by Querdel, Eva, Reinsch, Marina, Castro, Liesa, Köse, Deniz, Bähr, Andrea, Reich, Svenja, Geertz, Birgit, Ulmer, Bärbel, Schulze, Mirja, Lemoine, Marc D., Krause, Tobias, Lemme, Marta, Sani, Jascha, Shibamiya, Aya, Stüdemann, Tim, Köhne, Maria, Bibra, Constantin von, Hornaschewitz, Nadja, Pecha, Simon, Nejahsie, Yusuf, Mannhardt, Ingra, Christ, Torsten, Reichenspurner, Hermann, Hansen, Arne, Klymiuk, Nikolai, Krane, M., Kupatt, C., Eschenhagen, Thomas, Weinberger, Florian

“…Human engineered heart tissue (EHT) transplantation represents a potential regenerative strategy for patients with heart failure and has been successful in…”
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Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy by Moretti, A., Fonteyne, L., Giesert, F., Hoppmann, P., Meier, A. B., Bozoglu, T., Baehr, A., Schneider, C. M., Sinnecker, D., Klett, K., Fröhlich, T., Rahman, F. Abdel, Haufe, T., Sun, S., Jurisch, V., Kessler, B., Hinkel, R., Dirschinger, R., Martens, E., Jilek, C., Graf, A., Krebs, S., Santamaria, G., Kurome, M., Zakhartchenko, V., Campbell, B., Voelse, K., Wolf, A., Ziegler, T., Reichert, S., Lee, S., Flenkenthaler, F., Dorn, T., Jeremias, I., Blum, H., Dendorfer, A., Schnieke, A., Krause, S., Walter, M. C., Klymiuk, N., Laugwitz, K. L., Wolf, E., Wurst, W., Kupatt, C.

“…Frameshift mutations in the DMD gene, encoding dystrophin, cause Duchenne muscular dystrophy (DMD), leading to terminal muscle and heart failure in patients…”
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Will our cardiomyopathy patients accept gene therapy? by Doevendans, P. A., Kupatt, C., Giacca, M., Glijnis, P.

“…Novel techniques such as gene therapy are becoming available in an attempt to cure inherited diseases. Before these new therapies can be offered to patients,…”
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Contrast-induced acute kidney injury after computed tomography prior to transcatheter aortic valve implantation by Jochheim, D, Schneider, V.-S, Schwarz, F, Kupatt, C, Lange, P, Reiser, M, Massberg, S, Gutiérrez-Chico, J.-L, Mehilli, J, Becker, H.-C

“…Aim To identify independent predictors of contrast medium-induced acute kidney injury (CI-AKI) after enhanced multidetector-row computed tomography (MDCT)…”
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Involvement of CD95/Apo1/Fas in cell death after myocardial ischemia by Jeremias, I, Kupatt, C, Martin-Villalba, A, Habazettl, H, Schenkel, J, Boekstegers, P, Debatin, K M

“…The death of cardiac cells during ischemia and reperfusion is partially mediated by apoptosis, as seen, eg, in autopsy material of patients after acute…”
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Cardio-specific long-term gene expression in a porcine model after selective pressure-regulated retroinfusion of adeno-associated viral (AAV) vectors by Raake, P W, Hinkel, R, Müller, S, Delker, S, Kreuzpointner, R, Kupatt, C, Katus, H A, Kleinschmidt, J A, Boekstegers, P, Müller, O J

“…Cornerstone for an efficient cardiac gene therapy is the need for a vector system, which enables selective and long-term expression of the gene of interest. In…”
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Inhibition of Nuclear Factor κB Activation Attenuates Apoptosis Resistance in Lymphoid Cells by Jeremias, I., Kupatt, C., Baumann, B., Herr, I., Wirth, T., Debatin, K.M.

“…Death-inducing ligands (DILs) such as tumor necrosis factor α (TNFα) or the cytotoxic drug doxorubicin have been shown to activate a nuclear factor κB…”
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1068 POSTER Preconditioned Monocytic Endothelial Progenitor Cells Reduce Formation of Melanoma Metastases Through SPARC-driven Cell-cell Interactions by Defresne, F, Bouzin, C, Grandjean, M, Kupatt, C, Hatzopoulos, A.K, Feron, O

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Myocardial gene transfer by selective pressure-regulated retroinfusion of coronary veins by Boekstegers, P, von Degenfeld, G, Giehrl, W, Heinrich, D, Hullin, R, Kupatt, C, Steinbeck, G, Baretton, G, Middeler, G, Katus, H, Franz, W M

“…Catheter-based percutaneous transluminal gene delivery (PTGD) into the coronary artery still falls behind the expectations of an efficient myocardial gene…”
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Endothelial function and hemostasis by Becker, B F, Heindl, B, Kupatt, C, Zahler, S

“…The vascular endothelium influences not only the three classically interacting components of hemostasis: the vessel, the blood platelets and the clotting and…”
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Endothelial retargeting of AAV9 in vivo by Bozoglu, T, Lee, S, Ziegler, T, Kupatt, C

“…Abstract Background Adeno-associated virus (AAV) is favorable choice for gene transfer and gene editing applications in vivo, due to its low integration rate…”
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AAV based gene delivery to myocardium in rodents and pigs by Xiaofeng, J., Burdorf, L., Postrach, J., Bauer, A., Thein, E., Hinkel, R., Schumann, N., Büning, H., Reichart, B., Kupatt, C., Schmoeckel, M.

“…Objective:  To optimize transgene expression levels after AAV‐mediated gene transfer different delivery methods were compared in a rat (A) and porcine (B)…”
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AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury by Hinkel, Rabea, Ramanujam, Deepak, Kaczmarek, Veronika, Howe, Andrea, Klett, Katharina, Beck, Christina, Dueck, Anne, Thum, Thomas, Laugwitz, Karl-Ludwig, Maegdefessel, Lars, Weber, Christian, Kupatt, Christian, Engelhardt, Stefan

“…miR-21 is a central regulator of cardiac fibrosis, and its inhibition in small-animal models has been shown to be an effective antifibrotic strategy in various…”
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Angiographic and clinical outcome for the treatment of in-stent restenosis with sirolimus-eluting stent compared to vascular brachytherapy by Pohl, T, Kupatt, C, Steinbeck, G, Boekstegers, P

“…With the use of coronary stents for the treatment of coronary artery disease, in-stent restenosis became a major clinical problem. In this non-randomized…”
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AAV.Cas9 and AAV.SERCA2a strategies to mitigate heart failure in DMD pigs by Baehr, A, Hornaschewitz, N, Stirm, M, Hoppmann, P, Bozoglu, T, Klymiuk, N, Laugwitz, K L, Moretti, A, Wolf, E, Hajjar, R, Kupatt, C

“…Abstract Aims Duchenne muscular dystrophy is a devastating disease affecting skeletal muscle and heart, which is caused by loss-of-function mutations in the…”
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Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair by Ferraro, Bartolo, Leoni, Giovanna, Hinkel, Rabea, Ormanns, Steffen, Paulin, Nicole, Ortega-Gomez, Almudena, Viola, Joana R, de Jong, Renske, Bongiovanni, Dario, Bozoglu, Tarik, Maas, Sanne L, D'Amico, Michele, Kessler, Thorsten, Zeller, Tanja, Hristov, Michael, Reutelingsperger, Chris, Sager, Hendrik B, Döring, Yvonne, Nahrendorf, Matthias, Kupatt, Christian, Soehnlein, Oliver

“…Heart failure following myocardial infarction (MI) remains one of the major causes of death worldwide, and its treatment is a crucial challenge of…”
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Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs by Baehr, Andrea, Umansky, Kfir Baruch, Bassat, Elad, Jurisch, Victoria, Klett, Katharina, Bozoglu, Tarik, Hornaschewitz, Nadja, Solyanik, Olga, Kain, David, Ferraro, Bartolo, Cohen-Rabi, Renee, Krane, Markus, Cyran, Clemens, Soehnlein, Oliver, Laugwitz, Karl Ludwig, Hinkel, Rabea, Kupatt, Christian, Tzahor, Eldad

“…Background: Ischemic heart diseases are leading causes of death and reduced life quality worldwide. Although revascularization strategies significantly reduce…”
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Targeted overexpression of regnase-1 in the aorta prevents aneurysm growth in a murine model of Marfan syndrome by Noormalal, M, Remes, A, Schmiedel, N, Matzen, A, Hille, S, Bozoglu, T, Wolf, A, Zaradzki, M, Karck, M, Kupatt, C, Frank, D, Frey, N, Mueller, O J

“…Abstract Background/Introduction Marfan syndrome is a rare genetic disorder caused by mutations in the fibrillin-1 gene. This markedly affects the…”
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Man-machine interaction-based phenotyping preprocedurally identifies patients with severe aortic stenosis, who will not recover from cardiac damage following transcatheter aortic valve replacement by Rippen, E, Lachmann, M, Schuster, T, Xhepa, E, Von Scheidt, M, Harmsen, G, Yuasa, S, Kupatt, C, Joner, M, Laugwitz, K L

“…Abstract Background Severe aortic stenosis (AS) can lead to left heart dysfunction, pulmonary hypertension (PH), and eventually right heart failure. Clinical…”
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Effect of renin angiotensin system blockade following transcatheter aortic valve replacement is dose dependent by Ledwoch, J, Olbrich, I, Poch, F, Thalmann, R, Fellner, C, Stundl, A, Bradaric, C, Laugwitz, K.L, Kupatt, C

“…Abstract Background There is growing body of evidence from retrospective studies that inhibition of the renin angiotensin system (RAS) improves outcome after…”
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