Search Results - "Kunze‐Schumacher, Heike"

MicroRNA miR‐181a/b‐1 controls MAIT cell development by Winter, Samantha J, Kunze‐Schumacher, Heike, Imelmann, Esther, Grewers, Zoe, Osthues, Tabea, Krueger, Andreas

“…Mucosal‐associated invariant T (MAIT) cells constitute a major fraction of innate‐like T cells in humans with critical roles in defense against microbial…”
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miR‐191 modulates B‐cell development and targets transcription factors E2A, Foxp1, and Egr1 by Blume, Jonas, Ziętara, Natalia, Witzlau, Katrin, Liu, Yanshan, Sanchez, Oskar Ortiz, Puchałka, Jacek, Winter, Samantha J., Kunze‐Schumacher, Heike, Saran, Namita, Düber, Sandra, Roy, Bishnudeo, Weiss, Siegfried, Klein, Christoph, Wurst, Wolfgang, Łyszkiewicz, Marcin, Krueger, Andreas

“…The interdependence of posttranscriptional gene regulation via miRNA and transcriptional regulatory networks in lymphocyte development is poorly understood…”
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The Role of MicroRNAs in Development and Function of Regulatory T Cells - Lessons for a Better Understanding of MicroRNA Biology by Kunze-Schumacher, Heike, Krueger, Andreas

“…MicroRNAs (miRNAs) have emerged as critical posttranscriptional regulators of the immune system, including function and development of regulatory T (Treg)…”
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Modeling the Dynamics of T-Cell Development in the Thymus by Robert, Philippe A, Kunze-Schumacher, Heike, Greiff, Victor, Krueger, Andreas

“…The thymus hosts the development of a specific type of adaptive immune cells called T cells. T cells orchestrate the adaptive immune response through…”
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miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity by Łyszkiewicz, Marcin, Winter, Samantha J, Witzlau, Katrin, Föhse, Lisa, Brownlie, Rebecca, Puchałka, Jacek, Verheyden, Nikita A, Kunze-Schumacher, Heike, Imelmann, Esther, Blume, Jonas, Raha, Solaiman, Sekiya, Takashi, Yoshimura, Akihiko, Frueh, Jochen T, Ullrich, Evelyn, Huehn, Jochen, Weiss, Siegfried, Gutierrez, Maximiliano G, Prinz, Immo, Zamoyska, Rose, Ziętara, Natalia, Krueger, Andreas

“…The interdependence of selective cues during development of regulatory T cells (Treg cells) in the thymus and their suppressive function remains incompletely…”
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The transcription factor TAL1 and miR-17-92 create a regulatory loop in hematopoiesis by Meyer, Annekarin, Herkt, Stefanie, Kunze-Schumacher, Heike, Kohrs, Nicole, Ringleb, Julia, Schneider, Lucas, Kuvardina, Olga N., Oellerich, Thomas, Häupl, Björn, Krueger, Andreas, Seifried, Erhard, Bonig, Halvard, Lausen, Joern

“…A network of gene regulatory factors such as transcription factors and microRNAs establish and maintain gene expression patterns during hematopoiesis. In this…”
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miRNA miR-21 Is Largely Dispensable for Intrathymic T-Cell Development by Kunze-Schumacher, Heike, Winter, Samantha J, Imelmann, Esther, Krueger, Andreas

“…Development of T cells in the thymus is tightly controlled to continually produce functional, but not autoreactive, T cells. miRNAs provide a layer of…”
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HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response-Implications on HSCT Outcome by Blasczyk, Rainer, Kunze-Schumacher, Heike, Huyton, Trevor, Celik, Alexander A., Kraemer, Thomas, Bade-Doeding, Christina

“…The HLA-E locus encodes a nonclassical class Ib molecule that serves many immune functions from inhibiting NK cells to activating CTLs. Structural analysis of…”
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Releasing the concept of HLA‐allele specific peptide anchors in viral infections: A non‐canonical naturally presented human cytomegalovirus‐derived HLA‐A24:02 restricted peptide drives exquisite immunogenicity by Pump, Wiebke C., Schulz, Rebecca, Huyton, Trevor, Kunze‐Schumacher, Heike, Martens, Jörg, Hò, Gia‐Gia T., Blasczyk, Rainer, Bade‐Doeding, Christina

“…T‐cell receptors possess the unique ability to survey and respond to their permanently modified ligands, self HLA‐I molecules bound to non‐self peptides of…”
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Soluble HLA Technology as a Strategy to Evaluate the Impact of HLA Mismatches by Kunze-Schumacher, Heike, Bade-Doeding, Christina, Blasczyk, Rainer

“…HLA class I incompatibilities still remain one of the main barriers for unrelated bone marrow transplantation (BMT); hence the molecular understanding of how…”
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Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B∗15:02 by Bade-Doeding, Christina, Kunze-Schumacher, Heike, Kuhn, Joachim, Huyton, Trevor, Celik, Alexander A., Hò, Gia-Gia T., Simper, Gwendolin S., Blasczyk, Rainer

“…Among patients treated with the anticonvulsive and psychotropic drug carbamazepine (CBZ), approximately 10% develop severe and life-threatening adverse drug…”
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The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity by Simper, Gwendolin S., Gräser, Lareen S., Celik, Alexander A., Kuhn, Joachim, Kunze-Schumacher, Heike, Hò, Gia-Gia T., Blasczyk, Rainer, Pich, Andreas, Bade-Doeding, Christina

“…Drug hypersensitivity reactions that resemble acute immune reactions are linked to certain human leucocyte antigen (HLA) alleles. Severe and life-threatening…”
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A Micropolymorphism Altering the Residue Triad 97/114/156 Determines the Relative Levels of Tapasin Independence and Distinct Peptide Profiles for HLA-A24 Allotypes by Huyton, Trevor, Blasczyk, Rainer, Kunze-Schumacher, Heike, Badrinath, Soumya, Bade-Doeding, Christina

“…While many HLA class I molecules interact directly with the peptide loading complex (PLC) for conventional loading of peptides certain class I molecules are…”
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) by Radbruch, Andreas, Abrignani, Sergio, Akdis, Mübeccel, Andrä, Immanuel, Andreata, Francesco, Bacher, Petra, Barnaba, Vincenzo, Barros‐Martins, Joana, Baumjohann, Dirk, Beccaria, Cristian G., Bernardo, David, Boardman, Dominic A., Borger, Jessica, Böttcher, Chotima, Brockmann, Leonie, Cammarata, Ilenia, Cassotta, Antonino, Chirdo, Fernando Gabriel, Christakou, Eleni, Čičin‐Šain, Luka, Corbett, Alexandra J., Cornelis, Rebecca, Cosmi, Lorenzo, De Biasi, Sara, del Zotto, Genny, Di Rosa, Francesca, Dörner, Thomas, Dutertre, Charles‐Antoine, Evrard, Maximilien, Feuerer, Markus, Fillatreau, Simon, Follo, Marie, Fröbel, Julia, Gagliani, Nicola, Galletti, Giovanni, Garbi, Natalio, Ginhoux, Florent, Godfrey, Dale I., Gruarin, Paola, Haftmann, Claudia, Hansmann, Leo, Heine, Guido, Herrmann, Martin, Huber, Samuel, Huber, Johanna E., Huehn, Jochen, Hundemer, Michael, Hwang, William Y. K., Jäck, Hans‐Martin, Jani, Peter K., Keller, Baerbel, Knop, Laura, Knopf, Jasmin, Koay, Hui‐Fern, Krueger, Andreas, Kuehne, Jenny F., Kunze‐Schumacher, Heike, Kvistborg, Pia, Lenz, Daniel, Lino, Andreia C., Liotta, Francesco, Long, Heather M., Lugli, Enrico, Maggi, Laura, Manz, Rudolf Armin, Melchers, Fritz, Melzer, Susanne, Muñoz‐Ruiz, Miguel, Muscate, Franziska, Neumann, Katrin, Ng, Lai Guan, Niedobitek, Antonia, Almeida, Larissa Nogueira, Pallett, Laura J., Pockley, A. Graham, Pujol‐Autonell, Irma, Pulvirenti, Nadia, Quatrini, Linda, Quinn, Kylie M., Radbruch, Helena, Sakaguchi, Shimon, Sanderink, Lieke, Schauer, Christine, Schildberg, Frank A., Schober, Kilian, Schoen, Janina, Schulz, Axel R., Schulze, Julia, Simonetti, Sonia, Stark, Regina, Tarnok, Attila, Tornack, Julia, Verheyden, Nikita A., Ward‐Hartstonge, Kirsten A., Waskow, Claudia, Wiedemann, Annika, Wing, James, Wirz, Oliver, Yang, Jennie H. M., Yang, Juhao

“…The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive…”
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) by Acs, Andreas, Akdis, Mübeccel, Esser, Charlotte, Fehniger, Todd A., Feuerer, Markus, Förster, Irmgard, Frehse, Britta, Frischbutter, Stefan, Galbraith, David W., Garbi, Natalio, Gherardin, Nicholas A., Goda, Keisuke, Hahn, Jonas, Hansson, Goran, Hauser, Anja E., Anselmo, Achille, Hernández, Daniela C., Höllt, Thomas, Huang, Fang‐Ping, Baldari, Cosima T., Jani, Peter K., Jávega, Beatriz, Kalina, Tomas, Bari, Sudipto, Khan, Srijit, Kobow, Katja, Kroneis, Thomas, Kwok, Immanuel, LaRosa, Francesca, Leung, Leslie Y.T., Liotta, Francesco, Lohoff, Michael, López‐Botet, Miguel, Lovett‐Racke, Amy E., Lubberts, Erik, Mantovani, Alberto, Manz, Rudolf A., Maslinski, Wlodzimierz, Matarese, Giuseppe, Miller, Stephen D., Moran, Barry, Mosmann, Tim R., Multhoff, Gabriele, Nakayama, Toshinori, Neumann, Katrin, Oja, Anna, Ordonez, Diana, Becher, Burkhard, Panse, Isabel, Pattanapanyasat, Kovit, Peterson, Pärt, Petriz, Jordi, Pickl, Winfried F., Quinn, Kylie M., Remmerswaal, Ester B.M., Rieger, Aja M., Ruland, Jürgen, Saalmüller, Armin, Sakaguchi, Shimon, Sala‐de‐Oyanguren, Francisco, Sautes‐Fridman, Catherine, Schmid, Stephan, Schober, Kilian, Schüler, Thomas, Schulte, Reiner, Scott‐Algara, Daniel, Simon, Anna Katharina, Spidlen, Josef, Stall, Alan M., Stark, Regina, Tárnok, Attila, Trotter, Joe, Van Isterdael, Gert, Ward, Michael D., Ward‐Hartstonge, Kirsten A, Watzl, Carsten, Willimsky, Gerald, Busch, Dirk H., Zielinski, Christina, Zychlinsky, Arturo, Calzetti, Federica, Cammarata, Ilenia, Cao, Xuetao, Cardell, Susanna L., Casola, Stefano, Cassatella, Marco A., Christakou, Eleni, Clerici, Mario, Corbett, Alexandra J., Cosmi, Lorenzo, Davey, Martin S., Del Zotto, Genny, Dela Cruz, Gelo Victoriano, Dellabona, Paolo, Deniz, Günnur, Dolf, Andreas, Dörner, Thomas, Dress, Regine J., Dudziak, Diana, Ehrhardt, Götz R.A.

“…© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim These guidelines are a consensus work of a considerable number of members of the immunology and flow…”
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Interactions in the ESCRT-III network of the yeast Saccharomyces cerevisiae by Brune, Thomas, Kunze-Schumacher, Heike, Kölling, Ralf

“…Here, we examine the genetic interactions between ESCRT-III mutations in the yeast Saccharomyces cerevisiae . From the obtained interaction network, we make…”
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Micro RNA miR‐181a/b‐1 controls MAIT cell development by Winter, Samantha J, Kunze‐Schumacher, Heike, Imelmann, Esther, Grewers, Zoe, Osthues, Tabea, Krueger, Andreas

“…Abstract Mucosal‐associated invariant T (MAIT) cells constitute a major fraction of innate‐like T cells in humans with critical roles in defense against…”
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The polymorphism at residue 156 determines the HLA-B35 restricted peptide repertoire during HCMV infection by Abels, Wiebke C., Manandhar, Trishna, Kunze-Schumacher, Heike, Blasczyk, Rainer, Bade-Döding, Christina

“…Peptide selection in infected cells is not fully understood yet, but several indications point to the fact that there are differences to uninfected cells,…”
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Releasing the concept of HLA‐allele specific peptide anchors in viral infections: A non‐canonical naturally presented human cytomegalovirus‐derived HLA‐A24:02 restricted peptide drives exquisite immunogenicit y by Pump, Wiebke C., Schulz, Rebecca, Huyton, Trevor, Kunze‐Schumacher, Heike, Martens, Jörg, Hò, Gia‐Gia T., Blasczyk, Rainer, Bade‐Doeding, Christina

“…T‐cell receptors possess the unique ability to survey and respond to their permanently modified ligands, self HLA‐I molecules bound to non‐self peptides of…”
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OR20: THE MECHANISTIC DIFFERENCES IN HLA-ASSOCIATED DRUG HYPERSENSITIVITY by Kunze-Schumacher, Heike, Trevor, Huyton, Blasczyk, Rainer, Bade-Doeding, Christina

“…Severe drug hypersensitivity reactions that resemble acute GvHD are linked to certain specific HLA alleles. The most common hypersensitivity reactions occur…”
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