Search Results - "Kunze, K.L."

Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates by Ortiz de Montellano, P R, Kunze, K L

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N-Alkylprotoporphyrin IX formation in 3,5-dicarbethoxy-1,4-dihydrocollidine-treated rats. Transfer of the alkyl group from the substrate to the porphyrin by Ortiz de Montellano, P R, Beilan, H S, Kunze, K L

“…Administration of 3,5-dicarbethoxy-1,4-dihydrocollidine (DDC) to rats causes the accumulation of N-methylprotoporphyrin IX, a potent inhibitor of…”
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Destruction of cytochrome P-450 by ethylene. Structure of the resulting prosthetic heme adduct by Ortiz de Montellano, P R, Beilan, H S, Kunze, K L, Mico, B A

“…The prosthetic heme of cytochrome P-450 is converted during the metabolism of ethylene into an abnormal hepatic porphyrin. This porphyrin has been isolated,…”
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The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4 by Gallagher, E.P. (University of Washington, Seattle, WA.), Kunze, K.L, Stapleton, P.L, Eaton, D.L

“…The combined presence of CYP1A2 and 3A4, both of which oxidize aflatoxin B1 (AFB1) to the reactive aflatoxin B1-8,9-epoxide (AFBO) and to hydroxylated…”
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559 Mechanistic studies of covalent heme binding to CYP4B1 by Zheng, Y., Baer, B.R., Kneller, M.B., Henne, K.R., Kunze, K.L., Rettie, A.E.

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Topiramate and Phenytoin Pharmacokinetics During Repetitive Monotherapy and Combination Therapy to Epileptic Patients by Sachdeo, Rajesh C., Sachdeo, S.K., Levy, R.H., Streeter, A.J., Bishop, F.E., Kunze, K.L., Mather, G.G., Roskos, L.K., Shen, D.D., Thummel, K.E., Trager, W.F., Curtin, C. R., Doose, Dennis R., Gisclon, L.G., Bialer, Meir

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Electronic and geometric structures of several states of diatomic scandium nitride by Kunze, Kathryn L, Harrison, James F

“…The electronic and geometric structures of 15 scandium nitride species with formal {sigma},{pi},{pi} triple, {sigma},{pi} double {pi},{pi} double, {sigma}…”
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Energetics and electronic structure of chromium hexacarbonyl by Kunze, Kathryn L, Davidson, Ernest R

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Cytochrome P-450 heme moiety. The specific target in drug-induced heme alkylation by Correia, M A, Farrell, G C, Olson, S, Wong, J S, Schmid, R, Ortiz de Montellano, P R, Beilan, H S, Kunze, K L, Mico, B A

“…Exogenously administered heme is incorporated into rat hepatic cytochrome P-450 in vivo (Correia, M. A., Farrell, G. C. Schmid, R. S., Ortiz de Montellano, P…”
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Application of negative-ion chemical ionization isotope dilution gas chromatography--mass spectrometry to single-dose bioavailability studies of mefloquine by Neal, J M, Howald, W N, Kunze, K L, Lawrence, R F, Trager, W F

“…An electron-capture negative-ion chemical ionization gas chromatographic-mass spectrometric assay for mefloquine, an antimalarial drug used in the treatment of…”
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