Search Results - "Kunz, A."

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy by Ashton, Thomas M, McKenna, W Gillies, Kunz-Schughart, Leoni A, Higgins, Geoff S

“…Cancer cells have upregulated glycolysis compared with normal cells, which has led many to the assumption that oxidative phosphorylation (OXPHOS) is…”
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Spheroid-based drug screen: considerations and practical approach by Kunz-Schughart, Leoni A, Friedrich, Juergen, Seidel, Claudia, Ebner, Reinhard

“…Although used in academic research for several decades, 3D culture models have long been regarded expensive, cumbersome and unnecessary in drug development…”
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Elimination of charge carrier trapping in diluted semiconductors by Abbaszadeh, D., Kunz, A., Wetzelaer, G. A. H., Michels, J. J., Crăciun, N. I., Koynov, K., Lieberwirth, I., Blom, P. W. M.

“…In 1962, Mark and Helfrich demonstrated that the current in a semiconductor containing traps is reduced by N / N t r , with N the amount of transport sites, N…”
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Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1 by Peixoto, Rui T., Kunz, Portia A., Kwon, Hyungbae, Mabb, Angela M., Sabatini, Bernardo L., Philpot, Benjamin D., Ehlers, Michael D.

“…Adhesive contact between pre- and postsynaptic neurons initiates synapse formation during brain development and provides a natural means of transsynaptic…”
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Effect of thoracic cage width on surgery time and postoperative outcome in minimally invasive esophagectomy by Mann, C., Jezycki, T., Berlth, F., Hadzijusufovic, E., Uzun, E., Mähringer-Kunz, A., Lang, H., Klöckner, R., Grimminger, P. P.

“…Introduction Minimally invasive esophagectomy (MIE) for esophageal cancer is a complex procedure that reduces postoperative morbidity in comparison to open…”
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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia by Ashton, Thomas M., Fokas, Emmanouil, Kunz-Schughart, Leoni A., Folkes, Lisa K., Anbalagan, Selvakumar, Huether, Melanie, Kelly, Catherine J., Pirovano, Giacomo, Buffa, Francesca M., Hammond, Ester M., Stratford, Michael, Muschel, Ruth J., Higgins, Geoff S., McKenna, William Gillies

“…Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that…”
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Climatology of potential vorticity streamers and associated isentropic transport pathways across PV gradient barriers by Kunz, A., Sprenger, M., Wernli, H.

“…The European Centre for Medium‐Range Weather Forecasts reanalysis product ERA‐Interim from 1979 to 2011 is used to investigate potential vorticity (PV)…”
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Dynamical tropopause based on isentropic potential vorticity gradients by Kunz, A., Konopka, P., Müller, R., Pan, L. L.

“…Since its inception, the dynamical tropopause based on potential vorticity (PV) is identified by the PV gradient on isentropes. Conceptually, significant…”
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Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments by Zhang, Xiaonan, Fryknäs, Mårten, Hernlund, Emma, Fayad, Walid, De Milito, Angelo, Olofsson, Maria Hägg, Gogvadze, Vladimir, Dang, Long, Påhlman, Sven, Schughart, Leoni A. Kunz, Rickardson, Linda, D′Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Larsson, Rolf, Linder, Stig

“…Abnormal vascularization of solid tumours results in the development of microenvironments deprived of oxygen and nutrients that harbour slowly growing and…”
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Nanoparticles for radiooncology: Mission, vision, challenges by Kunz-Schughart, Leoni A, Dubrovska, Anna, Peitzsch, Claudia, Ewe, Alexander, Aigner, Achim, Schellenburg, Samuel, Muders, Michael H, Hampel, Silke, Cirillo, Giuseppe, Iemma, Francesca, Tietze, Rainer, Alexiou, Christoph, Stephan, Holger, Zarschler, Kristof, Vittorio, Orazio, Kavallaris, Maria, Parak, Wolfgang J, Mädler, Lutz, Pokhrel, Suman

“…Abstract Cancer is one of the leading non-communicable diseases with highest mortality rates worldwide. About half of all cancer patients receive radiation…”
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Presynaptic NMDA receptor mechanisms for enhancing spontaneous neurotransmitter release by Kunz, Portia A, Roberts, Adam C, Philpot, Benjamin D

“…NMDA receptors (NMDARs) are required for experience-driven plasticity during formative periods of brain development and are critical for neurotransmission…”
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Tumor-derived lactic acid modulates dendritic cell activation and antigen expression by Gottfried, Eva, Kunz-Schughart, Leoni A., Ebner, Stephanie, Mueller-Klieser, Wolfgang, Hoves, Sabine, Andreesen, Reinhard, Mackensen, Andreas, Kreutz, Marina

“…The tumor milieu can influence dendritic cell (DC) differentiation. We analyzed DC differentiation in a 3-dimensional tumor model and propose a new mechanism…”
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Clay-Based Nanocomposite Coating for Flexible Optoelectronics Applying Commercial Polymers by Kunz, Daniel A, Schmid, Jasmin, Feicht, Patrick, Erath, Johann, Fery, Andreas, Breu, Josef

“…Transparency, flexibility, and especially ultralow oxygen (OTR) and water vapor (WVTR) transmission rates are the key issues to be addressed for packaging of…”
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Preservation and reactivation of Candidatus Jettenia asiatica and Anammoxoglobus propionicus using different preservative agents by Viancelli, A., Pra, M.C., Scussiato, L.A., Cantão, M., Ibelli, A.M.G., Kunz, A.

“…Anaerobic ammonium oxidation (anammox) bacteria have peculiar characteristics that make them difficult to cultivate. The conservation of these microorganisms…”
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Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes by Dietl, Katrin, Renner, Kathrin, Dettmer, Katja, Timischl, Birgit, Eberhart, Karin, Dorn, Christoph, Hellerbrand, Claus, Kastenberger, Michael, Kunz-Schughart, Leoni A, Oefner, Peter J, Andreesen, Reinhard, Gottfried, Eva, Kreutz, Marina P

“…High concentrations of lactic acid (LA) are found under various pathophysiological conditions and are accompanied by an acidification of the environment. To…”
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Experimental anti-tumor therapy in 3-D: Spheroids - old hat or new challenge? by Friedrich, Juergen, Ebner, Reinhard, Kunz-Schughart, Leoni A.

“…Purpose: To give a state-of-the-art overview on the promise of three-dimensional (3-D) culture systems for anticancer drug development, with particular…”
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Molekulare Entschlüsselung von fleischigen Aromen aus Zwiebelfermentationen by Stöppelmann, F., Kunz, A., Zhang, Y.

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Swine manure treatment technologies as drivers for circular economy in agribusiness: A techno-economic and life cycle assessment approach by Hollas, C.E., Rodrigues, H.C., Bolsan, A.C., Venturin, B., Bortoli, M., Antes, F.G., Steinmetz, R.L.R., Kunz, A.

“…Anaerobic digestion has been employed as a technology capable of adding value to waste coupled with environmental impact mitigation. However, many issues need…”
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Reliability of extracellular contrast versus gadoxetic acid in assessing small liver lesions using liver imaging reporting and data system v.2018 and European association for the study of the liver criteria by Rimola, Jordi, Sapena, Víctor, Brancatelli, Giuseppe, Darnell, Anna, Forzenigo, Laura, Mähringer‐Kunz, Aline, Paisant, Anita, Renzulli, Matteo, Schima, Wolfgang, Terraz, Sylvain, Valls, Carlos, Wagner, Mathilde, Ayuso, Carmen, Vilgrain, Valerie, Reig, Maria, Ronot, Maxime

“…Background & Aims The diagnostic accuracy of Liver Imaging Reporting and Data System (LI‐RADS) v.2018 and European Association for the Study of the Liver…”
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Self-Regulation in Informal Workplace Learning: Influence of Organizational Learning Culture and Job Characteristics by Kittel, Anne F D, Kunz, Rebecca A C, Seufert, Tina

“…The digital shift leads to increasing changes. Employees can deal with changes through informal learning that enables needs-based development. For successful…”
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