Search Results - "Kunugi, Akiyoshi"

Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement by Suzuki, Atsushi, Kunugi, Akiyoshi, Tajima, Yasukazu, Suzuki, Noriko, Suzuki, Motohisa, Toyofuku, Masashi, Kuno, Haruhiko, Sogabe, Satoshi, Kosugi, Yohei, Awasaki, Yasuyuki, Kaku, Tomohiro, Kimura, Haruhide

“…Agonistic profiles of AMPA receptor (AMPA-R) potentiators may be associated with seizure risk and bell-shaped dose-response effects. Here, we report the…”
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Author Correction: Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement by Suzuki, Atsushi, Kunugi, Akiyoshi, Tajima, Yasukazu, Suzuki, Noriko, Suzuki, Motohisa, Toyofuku, Masashi, Kuno, Haruhiko, Sogabe, Satoshi, Kosugi, Yohei, Awasaki, Yasuyuki, Kaku, Tomohiro, Kimura, Haruhide

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Neuroinflammation and glycosylation-related cerebrospinal fluid proteins for predicting functional decline in amyotrophic lateral sclerosis: a proteomic study by Nakamura, Kimie, Fujita, Koji, Suzuki, Motohisa, Kunugi, Akiyoshi, Hirozane, Yoshihiko, Kunikata, Tomonori, Takahashi, Bitoku, Narazaki, Genta, Kondo, Hirofumi, Haji, Shotaro, Hirai, Keisuke, Izumi, Yuishin

“…BackgroundThe rate of disease progression varies widely among patients with amyotrophic lateral sclerosis (ALS). Prognostic assessment using biomarkers is…”
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Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington's Disease PSC-Derived Striatal Neurons by Lange, Jenny, Wood-Kaczmar, Alison, Ali, Aneesa, Farag, Sahar, Ghosh, Rhia, Parker, Jennifer, Casey, Caroline, Uno, Yumiko, Kunugi, Akiyoshi, Ferretti, Patrizia, Andre, Ralph, Tabrizi, Sarah J

“…Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene ( ). Disease progression is…”
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Preclinical characterization of AMPA receptor potentiator TAK‐137 as a therapeutic drug for schizophrenia by Tanaka, Maiko, Kunugi, Akiyoshi, Suzuki, Atsushi, Suzuki, Noriko, Suzuki, Motohisa, Kimura, Haruhide

“…The downregulation of the glutamate system may be involved in positive, negative, and cognitive symptoms of schizophrenia. Through enhanced glutamate…”
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Altered Psychomotor Behaviors in Mice Lacking Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) by Hashimoto, Hitoshi, Shintani, Norihito, Tanaka, Kazuhiro, Mori, Wakaba, Hirose, Megumi, Matsuda, Toshio, Sakaue, Masaki, Miyazaki, Jun-ichi, Niwa, Hitoshi, Tashiro, Fumi, Yamamoto, Kyohei, Koga, Kazumi, Tomimoto, Shuhei, Kunugi, Akiyoshi, Suetake, Sayoko, Baba, Akemichi

“…Pituitary adenylate cyclase-activating polypeptide (PACAP) has been conserved remarkably during evolution and is widely expressed in the mammalian brain. In…”
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HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production by Kunugi, Akiyoshi, Tajima, Yasukazu, Kuno, Haruhiko, Sogabe, Satoshi, Kimura, Haruhide

“…-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiators with brain-derived neurotrophic factor (BDNF)-induction potential…”
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Electrophysiological characterization of a novel AMPA receptor potentiator, TAK-137, in rat hippocampal neurons by Suzuki, Atsushi, Tajima, Yasukazu, Kunugi, Akiyoshi, Kimura, Haruhide

“…•TAK-137 is a potent and selective AMPA receptor potentiator.•TAK-137 and LY451646 have comparable enhancing effects on AMPA-induced currents.•TAK-137 has…”
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TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats by Hara, Hiroe, Suzuki, Atsushi, Kunugi, Akiyoshi, Tajima, Yasukazu, Yamada, Ryuji, Kimura, Haruhide

“…The N-methyl-d-aspartate receptor antagonist, ketamine, exhibits rapid and sustained antidepressant activity in patients with treatment-resistant depression…”
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TAK-137, an AMPA receptor potentiator with little agonistic effect, produces antidepressant-like effect without causing psychotomimetic effects in rats by Suzuki, Atsushi, Murakami, Koji, Tajima, Yasukazu, Hara, Hiroe, Kunugi, Akiyoshi, Kimura, Haruhide

“…Ketamine produces a rapid-onset antidepressant effect in patients with treatment-resistant depression (TRD), although it concurrently causes undesirable…”
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Desensitization, surface expression, and glycosylation of a functional, epitope-tagged type I PACAP (PAC1) receptor by Shintani, Norihito, Hashimoto, Hitoshi, Kunugi, Akiyoshi, Koyama, Yutaka, Yamamoto, Kyohei, Tomimoto, Shuhei, Mori, Wakaba, Matsuda, Toshio, Baba, Akemichi

“…To study desensitization and glycosylation of the type I pituitary adenylate cyclase-activating polypeptide (PACAP) receptor (PAC1R), a hemagglutinin (HA)…”
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TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window by Kunugi, Akiyoshi, Tanaka, Maiko, Suzuki, Atsushi, Tajima, Yasukazu, Suzuki, Noriko, Suzuki, Motohisa, Nakamura, Shinji, Kuno, Haruhiko, Yokota, Akihiro, Sogabe, Satoshi, Kosugi, Yohei, Awasaki, Yasuyuki, Kaku, Tomohiro, Kimura, Haruhide

“…Activation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPA-R) is a promising strategy to treat psychiatric and neurological diseases if…”
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Possible involvement of a cyclic AMP-dependent mechanism in PACAP-induced proliferation and ERK activation in astrocytes by Hashimoto, Hitoshi, Kunugi, Akiyoshi, Arakawa, Naohisa, Shintani, Norihito, Fujita, Takashi, Kasai, Atsushi, Kawaguchi, Chihiro, Morita, Yoshiko, Hirose, Megumi, Sakai, Yoshiyuki, Baba, Akemichi

“…In cultured astrocytes, PACAP activates extracellular signal-regulated kinase (ERK) and induces cell proliferation at picomolar concentrations. Here, we…”
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The regulatory mechanisms of PACAP expression in neuronal cells by Hashimoto, Hitoshi, Koga, Kazumi, Hagihara, Nami, Shintani, Norihito, Yamamoto, Kyohei, Tomimoto, Shuhei, Kunugi, Akiyoshi, Matsuda, Toshio, Baba, Akemichi

“…Pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression was analyzed in PC12 cells using the luciferase reporter gene systems, RT-PCR, and…”
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O-253 - The regulatory mechanisms of PACAP expression in neuronal cells by Hashimoto, Hitoshi, Koga, Kazumi, Hagihara, Nami, Shintani, Norihito, Yamamoto, Kyohei, Tomimoto, Shuhei, Kunugi, Akiyoshi, Matsuda, Toshio, Baba, Akemichi

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