Search Results - "Kuno, Hideyuki"

Formation of Bulky DNA Adducts by Non-Enzymatic Production of 1,2-Naphthoquinone-Epoxide from 1,2-Naphthoquinone under Physiological Conditions by Matsui, Takuya, Yamada, Naohito, Kuno, Hideyuki, Kanaly, Robert A

“…Quinones may be formed metabolically or abiotically from environmental pollutants and polycyclic aromatic hydrocarbons (PAHs); many are recognized as…”
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Characterization of N-(2,6-dimethylphenyl)hydroxylamine adducts of 2′-deoxyguanosine under weakly basic conditions by Matsui, Takuya, Yamada, Naohito, Kuno, Hideyuki, Kanaly, Robert A.

“…Aromatic amines are a class of chemical carcinogens that are activated by cytochrome P450 enzymes to form arylhydroxylamines that are conjugated to form…”
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Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury by Goda, Keisuke, Takahashi, Tadakazu, Kobayashi, Akio, Shoda, Toshiyuki, Kuno, Hideyuki, Sugai, Shoichiro

“…Drug-induced liver injury (DILI) is one of the serious and frequent drug-related adverse events. This adverse event is a main reason for regulatory action…”
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Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats by Kobayashi, Akio, Suzuki, Yusuke, Kuno, Hideyuki, Sugai, Shoichiro, Sakakibara, Hiroyuki, Shimoi, Kayoko

“…Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels are widely used as sensitive markers of possible tissue damage, particularly…”
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Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients by Kondo, Kazuma, Yamada, Naohito, Suzuki, Yusuke, Toyoda, Kaoru, Hashimoto, Tatsuji, Takahashi, Akemi, Kobayashi, Akio, Shoda, Toshiyuki, Kuno, Hideyuki, Sugai, Shoichiro

“…Acetaminophen (APAP) is a commonly used and effective analgesic and antipyretic agent. However, some patients encounter hepatotoxicity after repeated APAP…”
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Effects of spaced feeding on gene expression of hepatic transaminase and gluconeogenic enzymes in rats by Kobayashi, Akio, Yokoyama, Hideaki, Kataoka, Jiro, Ishida, Tomio, Kuno, Hideyuki, Sugai, Shoichiro, Sakakibara, Hiroyuki, Shimoi, Kayoko

“…Blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities are widely used as sensitive markers of liver toxicity. However, these…”
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Relationships between plasma and tissue transaminase activities in rats maintained under different feeding conditions by Kobayashi, Akio, Oshida, Shin-ichi, Yamazaki, Yuji, Maekawa, Tatsuya, Kuno, Hideyuki, Sugai, Shoichiro, Sakakibara, Hiroyuki, Shimoi, Kayoko

“…In order to verify the nutritional aspect of alterations of the plasma and tissue transaminase activities, rats were fed 4 hr per day for 35 days (the…”
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Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats by Kondo, Kazuma, Yamada, Naohito, Suzuki, Yusuke, Toyoda, Kaoru, Hashimoto, Tatsuji, Takahashi, Akemi, Kobayashi, Akio, Shoda, Toshiyuki, Kuno, Hideyuki, Sugai, Shoichiro

“…Acetaminophen (APAP) is a commonly used and effective analgesic and antipyretic agent. However, some patients encounter hepatotoxicity after repeated APAP…”
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Synthesis of 3'-Amino-3'-deoxyadenosine from Levoglucosenone by Kuno, Hideyuki, Niihata, Shigeo, Ebata, Takashi, Matsushita, Hajime

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Polyethylene glycol-modified lipase catalyzes asymmetric alcoholysis of ?-decalactone in n-decanol by Uemura, Takeshi, Furukawa, Makoto, Kodera, Yoh, Hiroto, Misao, Matsushima, Ayako, Kuno, Hideyuki, Matsushita, Hajime, Sakurai, Katsukiyo, Inada, Yuji

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Polyethylene glycol-modified lipase catalyzes asymmetric alcoholysis of δ-decalactone in n-decanol by UEMURA, T, FURUKAWA, M, KODERA, Y, HIROTO, M, MATSUSHIMA, A, KUNO, H, MATSUSHITA, H, SAKURAI, K, INADA, Y

“…Lipase from Pseudomonas cepacia was modified with 2,4-bis[O-methoxypoly(ethylene glycol)]-6-chloro-s-triazine(activated PEG sub(2)) to form PEG-lipase. The…”
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Synthesis of a useful chiral building block, (S)-5-acetoxy-2-penten-4-olide from D-glucose by HONDA, I, SHIBAGAKI, M, KOSEKI, K, KUNO, H, TAKAHASHI, K, MATSUSHITA, H

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