Search Results - "Kunnimalaiyaan, Muthusamy"

Tumor Suppressor Role of Notch‐1 Signaling in Neuroendocrine Tumors by Kunnimalaiyaan, Muthusamy, Chen, Herbert

“…A growing body of literature is demonstrating that Notch signaling is a more complex process than originally thought. Contradictory findings of notch‐1 acting…”
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Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines by Engelsgjerd, Samuel, Kunnimalaiyaan, Selvi, Kandil, Emad, Gamblin, T Clark, Kunnimalaiyaan, Muthusamy

“…High-risk neuroblastoma (NB) is lethal childhood cancer. Published data including ours have reported the anti-proliferative effect of Xanthohumol (XN), a…”
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Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growth by Yu, Xiao-Min, Jaskula-Sztul, Renata, Ahmed, Kamal, Harrison, April D, Kunnimalaiyaan, Muthusamy, Chen, Herbert

“…Anaplastic thyroid carcinoma (ATC) is an extremely aggressive malignancy with undifferentiated features, for which conventional treatments, including…”
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Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro by Kunnimalaiyaan, Selvi, Schwartz, Victoriana K, Jackson, Iris Alao, Clark Gamblin, T, Kunnimalaiyaan, Muthusamy

“…Neuroblastoma (NB) is a devastating disease. Despite recent advances in the treatment of NB, about 60% of high-risk NB will have relapse and therefore…”
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Current Management of Medullary Thyroid Cancer by Sippel, Rebecca S., Kunnimalaiyaan, Muthusamy, Chen, Herbert

“…Learning Objectives After completing this course, the reader will be able to: Evaluate a patient with a new diagnosis of medullary thyroid cancer. Use genetic…”
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Xanthohumol inhibits Notch signaling and induces apoptosis in hepatocellular carcinoma by Kunnimalaiyaan, Selvi, Sokolowski, Kevin M, Balamurugan, Mariappan, Gamblin, T Clark, Kunnimalaiyaan, Muthusamy

“…Despite improvement in therapeutic strategies, median survival in advanced hepatocellular carcinoma (HCC) remains less than one year. Therefore, molecularly…”
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Notch 1 signaling is active in ovarian cancer by Rose, Stephen L, Kunnimalaiyaan, Muthusamy, Drenzek, Jessica, Seiler, Nicole

“…Abstract Objective. Despite advances in chemotherapy and radical surgery, most advanced stage ovarian cancer patients die from their disease, highlighting the…”
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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, alters multiple signaling pathways in hepatocellular carcinoma cell lines by Kunnimalaiyaan, Selvi, Sokolowski, Kevin, Gamblin, T. Clark, Kunnimalaiyaan, Muthusamy

“…Abstract Introduction Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has preclinical efficacy in hepatocellular carcinoma (HCC),…”
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Inactivation of glycogen synthase kinase-3β, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells by Kunnimalaiyaan, Muthusamy, Vaccaro, Abram M., Ndiaye, Mary A., Chen, Herbert

“…Glycogen synthase kinase-3β (GSK-3β) is an important regulator of cell proliferation and survival. Conflicting observations have been reported regarding the…”
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Overexpression of the NOTCH1 Intracellular Domain Inhibits Cell Proliferation and Alters the Neuroendocrine Phenotype of Medullary Thyroid Cancer Cells by Kunnimalaiyaan, Muthusamy, Vaccaro, Abram M., Ndiaye, Mary A., Chen, Herbert

“…The role of NOTCH1 as an oncogene or tumor suppressor appears to be cell type-specific. Medullary thyroid cancer (MTC) cells characteristically express the…”
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Glycogen synthase kinase-3 inhibitor AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression by Kunnimalaiyaan, Selvi, Clark Gamblin, T, Kunnimalaiyaan, Muthusamy

“…Abstract Background Glycogen synthase kinase-3 (GSK-3) can act as either a tumour promoter or suppressor by its inactivation depending on the cell type. There…”
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Antiproliferative Effect of Chrysin on Anaplastic Thyroid Cancer by Phan, TramAnh, B.S, Yu, Xiao-Min, M.D., Ph.D, Kunnimalaiyaan, Muthusamy, Ph.D, Chen, Herbert, M.D., F.A.C.S

“…Background Anaplastic thyroid cancer (ATC) is an undifferentiated, aggressive malignancy, for which there are no effective therapies. Though ATCs only make up…”
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Valproic Acid Activates Notch‐1 Signaling and Regulates the Neuroendocrine Phenotype in Carcinoid Cancer Cells by Greenblatt, David Yu, Vaccaro, Abram M., Jaskula‐Sztul, Renata, Ning, Li, Haymart, Megan, Kunnimalaiyaan, Muthusamy, Chen, Herbert

“…Carcinoid tumors are neuroendocrine malignancies that frequently metastasize and secrete hormones that cause debilitating symptoms in patients. In this study…”
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Resveratrol Induces Notch2-Mediated Apoptosis and Suppression of Neuroendocrine Markers in Medullary Thyroid Cancer by Truong, Matthew, Cook, Mackenzie R., Pinchot, Scott N., Kunnimalaiyaan, Muthusamy, Chen, Herbert

“…Background Currently, complete surgical resection is the only curative option for medullary thyroid cancer (MTC). Previous work has shown the Notch pathway is…”
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The HDAC Inhibitor Trichostatin A Inhibits Growth of Small Cell Lung Cancer Cells by Platta, Christopher S., B.S, Greenblatt, David Yü, M.D, Kunnimalaiyaan, Muthusamy, Ph.D, Chen, Herbert, M.D., F.A.C.S

“…Background An estimated 162,460 people will die of lung cancer in the United States in 2006, making it the leading cause of cancer deaths. Small cell lung…”
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Potential Molecular Targeted Therapeutics: Role of PI3-K/Akt/mTOR Inhibition in Cancer by Sokolowski, Kevin M, Koprowski, Steven, Kunnimalaiyaan, Selvi, Balamurugan, Mariappan, Gamblin, T Clark, Kunnimalaiyaan, Muthusamy

“…Primary liver cancer is one of the most commonly occurring cancers worldwide. Hepatocellular carcinoma (HCC) represents the majority of primary liver cancer…”
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Curcumin-mediated regulation of Notch1/hairy and enhancer of split-1/survivin: molecular targeting in cholangiocarcinoma by Koprowski, Steven, BS, Sokolowski, Kevin, MD, Kunnimalaiyaan, Selvi, MS, Gamblin, T. Clark, MD, MS, Kunnimalaiyaan, Muthusamy, PhD

“…Abstract Background Cholangiocarcinoma (CCA) is highly malignant and characterized by poor prognosis with chemotherapeutic resistance. Therefore, continued…”
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Role of Akt inhibition on Notch1 expression in hepatocellular carcinoma: potential role for dual targeted therapy by Sokolowski, Kevin M., M.D, Balamurugan, Mariappan, Ph.D, Kunnimalaiyaan, Selvi, M.S, Wilson, Jacob, B.S, Gamblin, Thomas Clark, M.D., M.S., M.B.A., F.A.C.S, Kunnimalaiyaan, Muthusamy, Ph.D

“…Abstract Background We have shown that an Akt inhibitor, MK2206, reduces hepatocellular carcinoma (HCC) proliferation. To further delineate MK2206, we sought…”
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Valproic Acid Induces Notch1 Signaling in Small Cell Lung Cancer Cells by Platta, Christopher S., B.S, Greenblatt, David Yü, M.D, Kunnimalaiyaan, Muthusamy, Ph.D, Chen, Herbert, M.D., F.A.C.S

“…Background Small cell lung cancer (SCLC) is an aggressive malignancy. Current treatments yield dismal survival rates. We have previously demonstrated that…”
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Identification and validation of Notch pathway activating compounds through a novel high‐throughput screening method by Pinchot, Scott N., Jaskula‐Sztul, Renata, Ning, Li, Peters, Noel R., Cook, Mackenzie R., Kunnimalaiyaan, Muthusamy, Chen, Herbert

“…BACKGROUND: Carcinoids are neuroendocrine (NE) tumors with limited treatment options. Notch activation has been shown to suppress growth and hormone production…”
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