Search Results - "Kunlun He"
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Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19)
Published in Pathogens and disease (01-06-2020)“…ABSTRACT The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world has led to a pandemic with high morbidity and mortality…”
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2
The gut microbiome in atherosclerotic cardiovascular disease
Published in Nature communications (10-10-2017)“…The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to…”
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Associations between metabolic overweight/obesity phenotypes and mortality risk among patients with chronic heart failure
Published in Frontiers in endocrinology (Lausanne) (20-09-2024)“…Metabolic disorders and overweight or obesity are highly prevalent and intricately linked in patients with chronic heart failure (CHF). However, it remains…”
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4
Sirt3 attenuates post-infarction cardiac injury via inhibiting mitochondrial fission and normalization of AMPK-Drp1 pathways
Published in Cellular signalling (01-01-2019)“…Mitochondrial damage is involved in the pathogenesis of post-infarction cardiac injury. However, the upstream regulators of mitochondrial damage have not yet…”
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Probabilistic modeling personalized treatment pathways using electronic health records
Published in Journal of biomedical informatics (01-10-2018)“…[Display omitted] •To model personalized treatment pathways using electronic health records.•To extract latent topics and identify their sequential…”
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The miR-182/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-β-signalling pathways in an SMC/EC-crosstalk-associated manner
Published in Basic research in cardiology (01-12-2021)“…We recently identified oncologic miR-182 as a new regulator of pulmonary artery hypertension (PAH) that targets myeloid-associated differentiation marker…”
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Independent and combined effects of hypertension and diabetes on clinical outcomes in patients with COVID‐19: A retrospective cohort study of Huoshen Mountain Hospital and Guanggu Fangcang Shelter Hospital
Published in The journal of clinical hypertension (Greenwich, Conn.) (01-02-2021)“…It is widely recognized that hypertension is one of the major risk factor for disease severity and mortality in patients with coronavirus disease 2019…”
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The active lung microbiota landscape of COVID-19 patients through the metatranscriptome data analysis
Published in Bioimpacts (01-01-2022)“…Introduction: With the outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the interaction…”
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Treatment effect prediction with adversarial deep learning using electronic health records
Published in BMC medical informatics and decision making (14-12-2020)“…Treatment effect prediction (TEP) plays an important role in disease management by ensuring that the expected clinical outcomes are obtained after performing…”
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10
Metabolic score for insulin resistance as a predictor of mortality in heart failure with preserved ejection fraction: results from a multicenter cohort study
Published in Diabetology and metabolic syndrome (11-09-2024)“…The metabolic score for insulin resistance (METS-IR) has been validated as a novel, simple, and reliable surrogate marker for insulin resistance; however, its…”
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Integrated medical resource consumption stratification in hospitalized patients: an Auto Triage Management model based on accurate risk, cost and length of stay prediction
Published in Science China. Life sciences (01-05-2022)“…Triage management plays important roles in hospitalized patients for disease severity stratification and medical burden analysis. Although progression risks…”
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A deep learning framework assisted echocardiography with diagnosis, lesion localization, phenogrouping heterogeneous disease, and anomaly detection
Published in Scientific reports (02-01-2023)“…Echocardiography is the first-line diagnostic technique for heart diseases. Although artificial intelligence techniques have made great improvements in the…”
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An interpretable machine learning model based on a quick pre-screening system enables accurate deterioration risk prediction for COVID-19
Published in Scientific reports (30-11-2021)“…A high-performing interpretable model is proposed to predict the risk of deterioration in coronavirus disease 2019 (COVID-19) patients. The model was developed…”
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14
Association between the triglyceride-glucose index and the risk of mortality among patients with chronic heart failure: results from a retrospective cohort study in China
Published in Cardiovascular diabetology (07-07-2023)“…The triglyceride-glucose (TyG) index has been demonstrated to be a reliable surrogate marker of insulin resistance (IR) and an effective predictive index of…”
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F2RL3 Methylation in the Peripheral Blood as a Potential Marker for the Detection of Coronary Heart Disease: A Case-Control Study
Published in Frontiers in genetics (24-03-2022)“…Previous work has shown the association between blood-based methylation of coagulation factor II receptor-like 3 gene ( ) and cardiovascular mortality in…”
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Chronic diseases spectrum and multimorbidity in elderly inpatients based on a 12-year epidemiological survey in China
Published in BMC public health (17-02-2024)“…The number and proportion of the elderly population have been continuously increasing in China, leading to the elevated prevalence of chronic diseases and…”
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A novel prognostic model for patients with colon adenocarcinoma
Published in Frontiers in endocrinology (Lausanne) (27-02-2023)“…Colon adenocarcinoma (COAD) is a highly heterogeneous disease, which makes its prognostic prediction challenging. The purpose of this study was to investigate…”
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18
Multi-omics reveals changed energy metabolism of liver and muscle by caffeine after mice swimming
Published in PeerJ (San Francisco, CA) (03-01-2024)“…In recent years, numerous studies have investigated the effects of caffeine on exercise, and provide convincing evidence for its ergogenic effects on exercise…”
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Clinical characteristics of patients with confirmed and asymptomatic SARS-CoV-2 infection in China
Published in PloS one (23-08-2022)“…Objective To examine the clinical characteristics of patients with asymptomatic novel coronavirus disease 2019 (COVID-19) and compare them with those of…”
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Roles of S-Adenosylmethionine and Its Derivatives in Salt Tolerance of Cotton
Published in International journal of molecular sciences (30-05-2023)“…Salinity is a major abiotic stress that restricts cotton growth and affects fiber yield and quality. Although studies on salt tolerance have achieved great…”
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