The efficacy of pharmacological preconditioning in carotid endarterectomy

The efficacy of pharmacological preconditioning in carotid endarterectomy

To assess the efficacy of pharmacological preconditioning with actovegin in carotid endarterectomy. The study was based on the results of surgical treatment of 80 patients with hemodynamically significant uni- and bilateral lesions of carotid arteries. Half of the patients was operated immediately a...

Full description

Saved in:
Bibliographic Details
Published in:Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 116; no. 2; p. 34
Main Authors: Kuznetsov, M P, Fedin, A I, Karalkin, A V, Frolov, K B, Kunitsin, N V, Yumin, S M, Kholopova, E A, Knyazev, A V
Format: Journal Article
Language:Russian
Published: Russia (Federation) 2016
Subjects:
Aged
Aged, 80 and over
Brain - blood supply
Carotid Stenosis - surgery
Central Nervous System Stimulants - administration & dosage
Endarterectomy, Carotid
Female
Heme - administration & dosage
Heme - analogs & derivatives
Hemodynamics
Humans
Ischemic Preconditioning - methods
Male
Middle Aged
Preoperative Care - methods
Preoperative Period
Prospective Studies
Treatment Outcome
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To assess the efficacy of pharmacological preconditioning with actovegin in carotid endarterectomy. The study was based on the results of surgical treatment of 80 patients with hemodynamically significant uni- and bilateral lesions of carotid arteries. Half of the patients was operated immediately and others after pharmacological preconditioning with actovegin in dose of 1200 mg/daily during 1,5 months. Pharmacological preconditioning with actovegin increased the cerebral perfusion determined with one-photon emission computed tomography that improved significantly results of the surgery. There were significant changes in patient's state 7 days and 6 months after surgery. The improvement was correlated with the less number of asymptotic post-surgery ischemic strokes in different brain areas. A positive role of pharmacological preconditioning with actovegin in surgical treatment of carotid artery stenosis has been demonstrated.
ISSN:1997-7298
DOI:10.17116/jnevro20161162134-41