Search Results - "Kunisada, K."

Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes by Fujio, Y, Kunisada, K, Hirota, H, Yamauchi-Takihara, K, Kishimoto, T

“…We described recently the activation of the Janus kinasesignal transducer and activator of transcription (JakSTAT) and mitogen-activated protein (MAP) kinase…”
Get full text

Four types of interaction between pacemakers and EAS systems by Kunisada, K

Get full text

Acute endocapillary proliferative glomerulonephritis associated with human parvovirus B19 infection by Iwafuchi, Y, Morita, T, Kamimura, A, Kunisada, K, Ito, K, Miyazaki, S

“…A 36-year-old female developed acute nephritic syndrome associated with human parvovirus B19 (HPVB19) infection. Laboratory data showed proteinuria,…”
Get more information

Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene by Yamauchi-Takihara, K., Nakajima-Taniguchi, C., Matsui, H., Fujio, Y., Kunisada, K., Nagata, S., Kishimoto, T.

“…OBJECTIVE: The disease-bearing genes for hypertrophic cardiomyopathy (HCM) in HCM families have been identified as the beta-myosin heavy chain,…”
Get full text

G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes by Komuro, Issei, Harada, Mutsuo, Qin, Yingjie, Takano, Hiroyuki, Minamino, Tohru, Zou, Yunzeng, Toko, Haruhiro, Ohtsuka, Masashi, Matsuura, Katsuhisa, Sano, Masanori, Nishi, Jun-ichiro, Iwanaga, Koji, Akazawa, Hiroshi, Kunieda, Takeshige, Zhu, Weidong, Hasegawa, Hiroshi, Kunisada, Keita, Nagai, Toshio, Nakaya, Haruaki, Yamauchi-Takihara, Keiko

“…Granulocyte colony-stimulating factor (G-CSF) was reported to induce myocardial regeneration by promoting mobilization of bone marrow stem cells to the injured…”
Get full text

Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines: Inhibition of JAK3/STAT3 Signaling Induces Apoptosis and Cell Cycle Arrest of Colon Carcinoma Cells by Lin, Quan, Lai, Raymond, Chirieac, Lucian R, Li, Changping, Thomazy, Vilmos A, Grammatikakis, Ioannis, Rassidakis, George Z, Zhang, Wei, Fujio, Yasushi, Kunisada, Keita, Hamilton, Stanley R, Amin, Hesham M

“…Signal transducer and activator of transcription 3 (STAT3) has oncogenic potential. The biological effects of STAT3 have not been studied extensively in the…”
Get full text

Selective inhibition of STAT3 induces apoptosis and G cell cycle arrest in ALK-positive anaplastic large cell lymphoma by Amin, Hesham M, McDonnell, Timothy J, Ma, Yupo, Lin, Quan, Fujio, Yasushi, Kunisada, Keita, Leventaki, Vasiliki, Das, Pamela, Rassidakis, George Z, Cutler, Cathy, Medeiros, L Jeffrey, Lai, Raymond

“…Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is an aberrant fusion gene product expressed in a subset of cases of anaplastic large cell lymphoma (ALCL)…”
Get full text

A case of langerhans cell histiocytosis of the mandible that spontaneously regressed after biopsy in a child by Ono, Kisho, Okui, Tatsuo, Kunisada, Yuki, Obata, Kyoichi, Masui, Masanori, Ryumon, Shoji, Ibaragi, Soichiro, Nakamura, Tomoya, Sasaki, Akira

“…In younger patients of LCH, we should consider that the effectiveness of follow‐up without aggressive treatment for SS‐type LCH in the oral and maxillofacial…”
Get full text

Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction by NEGORO, Shinji, KUNISADA, Keita, TONE, Eiroh, FUNAMOTO, Masanobu, OH, Hidemasa, KISHIMOTO, Tadamitsu, YAMAUCHI-TAKIHARA, Keiko

“…We reported that the activation of gp130 transduced hypertrophic and cytoprotective signals via Janus kinase/signal transducer and activator of transcription…”
Get full text

Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase by NEGORO, Shinji, KUNISADA, Keita, HIROTA, Hisao, KISHIMOTO, Tadamitsu, YAMAUCHI-TAKIHARA, Keiko, FUJIO, Yasushi, FUNAMOTO, Masanobu, DARVILLE, Marline I, EIZIRIK, Décio L, OSUGI, Tomoaki, IZUMI, Masahiro, OSHIMA, Yuichi, NAKAOKA, Yoshikazu

“…Mice with cardiac-specific overexpression of signal transducer and activator of transcription 3 (STAT3) are resistant to doxorubicin-induced damage. The STAT3…”
Get full text

Signal Transducer and Activator of Transcription 3 in the Heart Transduces Not Only a Hypertrophic Signal but a Protective Signal against Doxorubicin-Induced Cardiomyopathy by Kunisada, Keita, Negoro, Shinji, Tone, Eiroh, Funamoto, Masanobu, Osugi, Tomoaki, Yamada, Shuichi, Okabe, Masaru, Kishimoto, Tadamitsu, Yamauchi-Takihara, Keiko

“…The signal transducer and activator of transcription (STAT) 3, a transcriptional factor downstream of several cytokines, is activated by Janus kinase families…”
Get full text

Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction by NEGORO, Shinji, OH, Hidemasa, TONE, Eiroh, KUNISADA, Keita, FUJIO, Yasushi, WALSH, Kenneth, KISHIMOTO, Tadamitsu, YAMAUCHI-TAKIHARA, Keiko

“…We recently reported that the activation of glycoprotein (gp) 130 by leukemia inhibitory factor (LIF) upregulates Bcl-xL and exerts antiapoptotic effects in…”
Get full text

Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes by Kunisada, K, Tone, E, Fujio, Y, Matsui, H, Yamauchi-Takihara, K, Kishimoto, T

“…gp130, a signal transducer of the IL-6-related cytokines, is expressed ubiquitously, including in the heart. The activation of gp130 in cardiac myocytes was…”
Get full text

Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart by Osugi, Tomoaki, Oshima, Yuichi, Fujio, Yasushi, Funamoto, Masanobu, Yamashita, Atsuko, Negoro, Shinji, Kunisada, Keita, Izumi, Masahiro, Nakaoka, Yoshikazu, Hirota, Hisao, Okabe, Masaru, Yamauchi-Takihara, Keiko, Kawase, Ichiro, Kishimoto, Tadamitsu

“…Signal transducer and activator of transcription 3 (STAT3) functions in cell proliferation, differentiation, and cell survival. Previously, we have…”
Get full text

Case of hypothyroidism and hypoparathyroidism discovered by fainting spells by Kunisada, K, Nishimura, S, Sati, J, Nagase, R, Ono, K, Makihata, K, Iko, S, Miyake, S, Nachida, K, Takahashi, K

Get full text

Activation of Phosphatidylinositol 3-Kinase through Glycoprotein 130 Induces Protein Kinase B and p70 S6 Kinase Phosphorylation in Cardiac Myocytes by Oh, H, Fujio, Y, Kunisada, K, Hirota, H, Matsui, H, Kishimoto, T, Yamauchi-Takihara, K

“…Phosphatidylinositol (PI) 3-kinase is known to be activated by cytokine stimulation through different types of receptors to transduce intracellular responses…”
Get full text

Signal Transducer and Activator of Transcription 3 Is Required for Glycoprotein 130-mediated Induction of Vascular Endothelial Growth Factor in Cardiac Myocytes by Funamoto, Masanobu, Fujio, Yasushi, Kunisada, Keita, Negoro, Shinji, Tone, Eiroh, Osugi, Tomoaki, Hirota, Hisao, Izumi, Masahiro, Yoshizaki, Kazuyuki, Walsh, Kenneth, Kishimoto, Tadamitsu, Yamauchi-Takihara, Keiko

“…Activation of glycoprotein (gp) 130 transduces hypertrophic and cytoprotective signals in cardiac myocytes. In the present study, we have demonstrated that…”
Get full text

Multiple cystic adenocarcinoma of the lung by Kunisada, Kouichi, Komoto, Reiko, Tanimoto, Yasushi, Kiura, Katsuyuki, Ueoka, Hiroshi, Kataoka, Mikio, Harada, Mine, Aoe, Motoi, Shimizu, Nobuyoshi, Shibayama, Takuo

Get full text

Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-κB and NF-IL6 in cardiac myocytes by MATSUI, H, IHARA, Y, FUJIO, Y, KUNISADA, K, AKIRA, S, KISHIMOTO, T, YAMAUCHI-TAKIHARA, K

“…We have previously reported that interleukin (IL)-6 is induced by hypoxic stimulation in cardiac myocytes. In the present study, we examined the induction of…”
Get full text

Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes by KUNISADA, K, HIROTA, H, FUJIO, Y, MATSUI, H, TANI, Y, YAMAUCHI-TAKIHARA, K, KISHIMOTO, T

“…Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Downstream of gp130, two signal-transducing pathways have been recognized,…”
Get full text