Search Results - "Kuninaka, Yumi"

Immune Mechanisms of Pulmonary Fibrosis with Bleomycin by Ishida, Yuko, Kuninaka, Yumi, Mukaida, Naofumi, Kondo, Toshikazu

“…Fibrosis and structural remodeling of the lung tissue can significantly impair lung function, often with fatal consequences. The etiology of pulmonary fibrosis…”
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Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3–CCR5 axis by Ishida, Yuko, Kuninaka, Yumi, Nosaka, Mizuho, Kimura, Akihiko, Taruya, Akira, Furuta, Machi, Mukaida, Naofumi, Kondo, Toshikazu

“…Inflammatory mediators such as cytokines and chemokines are crucially involved in the development of abdominal aortic aneurysm (AAA). Here we report that CaCl…”
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Pivotal Involvement of the CX3CL1-CX3CR1 Axis for the Recruitment of M2 Tumor-Associated Macrophages in Skin Carcinogenesis by Ishida, Yuko, Kuninaka, Yumi, Yamamoto, Yuki, Nosaka, Mizuho, Kimura, Akihiko, Furukawa, Fukumi, Mukaida, Naofumi, Kondo, Toshikazu

“…We previously revealed the crucial roles of a chemokine, CX3CL1, and its receptor, CX3CR1, in skin wound healing. Although repeated wounds frequently develop…”
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Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration by Ishida, Yuko, Kimura, Akihiko, Nosaka, Mizuho, Kuninaka, Yumi, Hemmi, Hiroaki, Sasaki, Izumi, Kaisho, Tsuneyasu, Mukaida, Naofumi, Kondo, Toshikazu

“…The potential role of macrophages in pulmonary fibrosis (PF) prompted us to evaluate the roles of CX3CR1, a chemokine receptor abundantly expressed in…”
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Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing by Ishida, Yuko, Kimura, Akihiko, Kuninaka, Yumi, Inui, Masanori, Matsushima, Kouji, Mukaida, Naofumi, Kondo, Toshikazu

“…BM-derived endothelial progenitor cells (EPCs) are critical and essential for neovascularization in tissue repair and tumorigenesis. EPCs migrate from BM to…”
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Macrophage polarity and wound age determination by Kuninaka, Yumi, Ishida, Yuko, Ishigami, Akiko, Nosaka, Mizuho, Matsuki, Jumpei, Yasuda, Haruki, Kofuna, Ayumi, Kimura, Akihiko, Furukawa, Fukumi, Kondo, Toshikazu

“…We investigated the dynamics of the gene expression of M1 and M2 macrophage markers during skin wound healing in mice. Expression of M1-macrophage markers,…”
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Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9‐genome editing promotes antitumor immunity and suppresses ovarian cancer progression by Yahata, Tamaki, Mizoguchi, Mika, Kimura, Akihiko, Orimo, Takashi, Toujima, Saori, Kuninaka, Yumi, Nosaka, Mizuho, Ishida, Yuko, Sasaki, Izumi, Fukuda‐Ohta, Yuri, Hemmi, Hiroaki, Iwahashi, Naoyuki, Noguchi, Tomoko, Kaisho, Tsuneyasu, Kondo, Toshikazu, Ino, Kazuhiko

“…Programmed cell death ligand 1 (PD‐L1) on tumor cells suppresses anti‐tumor immunity and has an unfavorable prognostic impact in ovarian cancer patients. We…”
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Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia by Kuninaka, Yumi, Ishida, Yuko, Nosaka, Mizuho, Ishigami, Akiko, Taruya, Akira, Shimada, Emi, Kimura, Akihiko, Yamamoto, Hiroki, Ozaki, Mitsunori, Furukawa, Fukumi, Kondo, Toshikazu

“…Heme oxygenase-1 (HO-1), an inducible stress-response protein, exerts anti-oxidant and anti-apoptotic effects. However, its significance in forensic diagnosis…”
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Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice by Ishida, Yuko, Zhang, Siying, Kuninaka, Yumi, Ishigami, Akiko, Nosaka, Mizuho, Harie, Isui, Kimura, Akihiko, Mukaida, Naofumi, Kondo, Toshikazu

“…Intense neutrophil infiltration into the liver is a characteristic of acetaminophen-induced acute liver injury. Neutrophil elastase is released by neutrophils…”
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Application and limitation of a biological clock-based method for estimating time of death in forensic practices by Kimura, Akihiko, Ishida, Yuko, Nosaka, Mizuho, Ishigami, Akiko, Yamamoto, Hiroki, Kuninaka, Yumi, Hata, Satoshi, Ozaki, Mitsunori, Kondo, Toshikazu

“…Estimating time of death is one of the most important problems in forensics. Here, we evaluated the applicability, limitations and reliability of the developed…”
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Crucial Involvement of IL-6 in Thrombus Resolution in Mice via Macrophage Recruitment and the Induction of Proteolytic Enzymes by Nosaka, Mizuho, Ishida, Yuko, Kimura, Akihiko, Kuninaka, Yumi, Taruya, Akira, Ozaki, Mitsunori, Tanaka, Atushi, Mukaida, Naofumi, Kondo, Toshikazu

“…After the ligation of the inferior vena cava (IVC) of wild-type (WT) mice, venous thrombi formed and grew progressively until 5 days and resolved thereafter…”
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Forensic significance of intracardiac expressions of Nrf2 in acute myocardial ischemia by Hiyamizu, Shion, Ishida, Yuko, Yasuda, Haruki, Kuninaka, Yumi, Nosaka, Mizuho, Ishigami, Akiko, Shimada, Emi, Kimura, Akihiko, Yamamoto, Hiroki, Osako, Miyu, Zhang, Wei, Goto, Utako, Kamata, Ten, Kondo, Toshikazu

“…When exposed to oxidative and electrophilic stress, a protective antioxidant response is initiated by nuclear factor erythroid 2-related factor 2 (Nrf2)…”
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Protective roles of thrombomodulin in cisplatin-induced nephrotoxicity through the inhibition of oxidative and endoplasmic reticulum stress by Yamamoto, Hiroki, Ishida, Yuko, Zhang, Siying, Osako, Miyu, Nosaka, Mizuho, Kuninaka, Yumi, Ishigami, Akiko, Iwahashi, Yuya, Aragane, Miki, Matsumoto, Lennon, Kimura, Akihiko, Kondo, Toshikazu

“…Cisplatin is an effective chemotherapeutic agent widely used for the treatment of various solid tumors. However, cisplatin has an important limitation in its…”
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Intrathrombotic appearances of AQP-1 and AQP-3 in relation to thrombus age in murine deep vein thrombosis model by Nosaka, Mizuho, Ishida, Yuko, Kuninaka, Yumi, Ishigami, Akiko, Taruya, Akira, Shimada, Emi, Hashizume, Yumiko, Yamamoto, Hiroki, Kimura, Akihiko, Furukawa, Fukumi, Kondo, Toshikazu

“…Aquaporins (AQPs) are membrane-bound proteins for water transportation and are useful for diagnosing drowning and wound vitality in forensic pathology. Here,…”
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Forensic pathological study on temporal appearance of dendritic cells in skin wounds by Kuninaka, Yumi, Ishida, Yuko, Nosaka, Mizuho, Shimada, Emi, Kimura, Akihiko, Ozaki, Mitsunori, Hata, Satoshi, Michiue, Tomomi, Yamamoto, Hiroki, Furukawa, Fukumi, Eisenmenger, Wolfgang, Kondo, Toshikazu

“…Dendritic cells (DCs) can essentially contribute to innate and adaptive immune system in various organs. A double-color immunofluorescence analysis was carried…”
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Forensic application of epidermal AQP3 expression to determination of wound vitality in human compressed neck skin by Ishida, Yuko, Kuninaka, Yumi, Nosaka, Mizuho, Shimada, Emi, Hata, Satoshi, Yamamoto, Hiroki, Hashizume, Yumiko, Kimura, Akihiko, Furukawa, Fukumi, Kondo, Toshikazu

“…In forensic practices, it is often difficult to determine wound vitality in compression marks of the neck with naked eyes. AQP1 and AQP3 are the major water…”
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The application of autophagy to thrombus age estimation in murine deep vein thrombosis model by Nosaka, Mizuho, Ishida, Yuko, Kuninaka, Yumi, Taruya, Akira, Kimura, Akihiko, Shimada, Emi, Yamamoto, Hiroki, Michiue, Tomomi, Furukawa, Fukumi, Kondo, Toshikazu

“…We immunohistochemically examined the intrathrombotic dynamics of autophagy during thrombogenesis using murine deep vein thrombosis (DVT) models. To perform…”
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Relationship between intrathrombotic appearance of HSP27 and HSP70 and thrombus ages in a  murine model of deep vein thrombosis by Nosaka, Mizuho, Ishida, Yuko, Kuninaka, Yumi, Ishigami, Akiko, Taruya, Akira, Shimada, Emi, Hashizume, Yumiko, Yamamoto, Hiroki, Kimura, Akihiko, Furukawa, Fukumi, Kondo, Toshikazu

“…Heat shock proteins (HSPs) are molecular chaperones whose primary function is cytoprotection, supporting cell survival under (sub) lethal conditions. They have…”
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Forensic application of epidermal expression of HSP27 and HSP70 for the determination of wound vitality in human compressed neck skin by Zhang, Siying, Ishida, Yuko, Ishigami, Akiko, Nosaka, Mizuho, Kuninaka, Yumi, Yasuda, Haruki, Kofuna, Ayumi, Matsuki, Jumpei, Osako, Miyu, Zhang, Wei, Kimura, Akihiko, Furukawa, Fukumi, Kondo, Toshikazu

“…Estimating the age and vitality of human skin wounds is essential in forensic practice, and the use of immunohistochemical parameters in this regard remains a…”
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Postmortem distribution of acephate and its metabolite methamidophos in body fluids and organ tissues of an intoxication case by Takayasu, Tatsunori, Yamamoto, Hiroki, Ishida, Yuko, Nosaka, Mizuho, Kuninaka, Yumi, Shimada, Emi, Kawaguchi, Mariko, Kimura, Akihiko, Kondo, Toshikazu

“…•This report an intoxication case caused by the ingestion of the pesticide Ortoran®, which consists of 50% acephate.•Based on these results and autopsy…”
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