Search Results - "Kunimoto, Dennis Y."

Future Path Toward TB Vaccine Development: Boosting BCG or Re-educating by a New Subunit Vaccine by Gupta, Nancy, Garg, Saurabh, Vedi, Satish, Kunimoto, Dennis Y, Kumar, Rakesh, Agrawal, Babita

“…Tuberculosis (TB), an infectious disease caused by ( ), kills 5,000 people per day globally. Rapid development and spread of various multi drug-resistant…”
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Program-wide review and follow-up of erythema Induratum of Bazin and tuberculosis-associated ocular inflammation management in a TB low-incidence setting: need for improved treatment candidate selection, therapy standardization, and care collaboration by Connors, William J, Fisher, Dina A, Kunimoto, Dennis Y, Jarand, Julie M

“…Erythema induratum of Bazin (EIB) - nodular vasculitis associated with Mycobacterium tuberculosis (TB) - and Tuberculosis-Associated Ocular Inflammation…”
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Harnessing Innate Immunity to Treat Mycobacterium tuberculosis Infections: Heat-Killed Caulobacter crescentus as a Novel Biotherapeutic by Gupta, Nancy, Vedi, Satish, Garg, Saurabh, Loo, Eric, Li, Jie, Kunimoto, Dennis Y, Kumar, Rakesh, Agrawal, Babita

“…Tuberculosis, caused by ( ), is a serious and devastating infectious disease worldwide. Approximately a quarter of the world population harbors latent…”
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Novel lipopeptides of ESAT-6 induce strong protective immunity against Mycobacterium tuberculosis : Routes of immunization and TLR agonists critically impact vaccine’s efficacy by Gupta, Nancy, Vedi, Satish, Kunimoto, Dennis Y, Agrawal, Babita, Kumar, Rakesh

“…Highlights • Novel subunit vaccine for Mtb by using simple lipid (palmitic acid) modified peptides from ESAT-6 protein. • Lipopeptides induce significant…”
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Investigation of C-5 alkynyl (alkynyloxy or hydroxymethyl) and/or N-3 propynyl substituted pyrimidine nucleoside analogs as a new class of antimicrobial agents by Garg, Saurabh, Shakya, Neeraj, Srivastav, Naveen C., Agrawal, Babita, Kunimoto, Dennis Y., Kumar, Rakesh

“…[Display omitted] The resurgence of mycobacterial infections and the emergence of drug-resistant strains urgently require a new class of agents that are…”
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3′-Bromo Analogues of Pyrimidine Nucleosides as a New Class of Potent Inhibitors of Mycobacterium tuberculosis by Shakya, Neeraj, Srivastav, Naveen C, Desroches, Nancy, Agrawal, Babita, Kunimoto, Dennis Y, Kumar, Rakesh

“…Tuberculosis (TB) is a major health problem worldwide. We herein report a new class of pyrimidine nucleosides as potent inhibitors of Mycobacterium…”
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Inhibition of Mycobacterial Replication by Pyrimidines Possessing Various C-5 Functionalities and Related 2′-Deoxynucleoside Analogues Using in Vitro and in Vivo Models by Srivastav, Naveen C, Rai, Dinesh, Tse, Christopher, Agrawal, B, Kunimoto, Dennis Y, Kumar, Rakesh

“…Tuberculosis (TB) has become an increasing problem since the emergence of human immunodeficiency virus and increasing appearance of drug-resistant strains…”
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Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides by Johar, Monika, Manning, Tracey, Kunimoto, Dennis Y., Kumar, Rakesh

“…Various 5-substituted unnatural pyrimidine nucleosides were synthesized and investigated as potential inhibitors of mycobacterial growth as anti-tuberculosis…”
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Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors by Shakya, Neeraj, Srivastav, Naveen C., Bhavanam, Sudha, Tse, Chris, Desroches, Nancy, Agrawal, Babita, Kunimoto, Dennis Y., Kumar, Rakesh

“…Discovery of novel antimycobacterial compounds that work on distinctive targets and by diverse mechanisms of action is urgently required for the treatment of…”
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Growth Inhibition of Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium In Vitro:  Effect of 1-β-d-2‘-Arabinofuranosyl and 1-(2‘-Deoxy-2‘-fluoro-β-d-2‘-ribofuranosyl) Pyrimidine Nucleoside Analogs by Johar, Monika, Manning, Tracey, Tse, Christopher, Desroches, Nancy, Agrawal, B, Kunimoto, Dennis Y, Kumar, Rakesh

“…The resurgence of tuberculosis and the emergence of multiple-drug-resistant strains of Mycobacteria necessitate the search for new classes of antimycobacterial…”
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Inhibition of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium avium by Novel Dideoxy Nucleosides by Rai, Dinesh, Johar, Monika, Srivastav, Naveen C, Manning, Tracey, Agrawal, B, Kunimoto, Dennis Y, Kumar, Rakesh

“…The prevalence of tuberculosis (TB) and mutidrug-resistant tuberculosis (MDR-TB) has been increasing, leading to serious infections, high mortality, and a…”
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Studies on acyclic pyrimidines as inhibitors of mycobacteria by Srivastav, Naveen C., Manning, Tracey, Kunimoto, Dennis Y., Kumar, Rakesh

“…In vitro anti-mycobacterial activities of several 5-substituted acyclic pyrimidine nucleosides containing 1-(2-hydroxyethoxy)methyl and…”
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Antimycobacterial activities of 5-alkyl (or halo)-3′-substituted pyrimidine nucleoside analogs by Srivastav, Naveen C., Shakya, Neeraj, Bhavanam, Sudha, Agrawal, Amogh, Tse, Chris, Desroches, Nancy, Kunimoto, Dennis Y., Kumar, Rakesh

“…Several 5-alkyl (or halo)-3′-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis,…”
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Design and Studies of Novel 5-Substituted Alkynylpyrimidine Nucleosides as Potent Inhibitors of Mycobacteria by Rai, Dinesh, Johar, Monika, Manning, Tracey, Agrawal, B, Kunimoto, Dennis Y, Kumar, Rakesh

“…We herein report a new category of 5-substituted pyrimidine nucleosides as potent inhibitors of mycobacteria. A series of 5-alkynyl derivatives of…”
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Changing epidemiology of tuberculosis detected by an 8-year retrospective laboratory study in a tertiary teaching hospital in central Saudi Arabia by Somily, Ali M, Naeem, Tahir, Habib, Hanan A, Sarwar, Mohammed S, Kunimoto, Dennis Y, Kambal, Abdelmageed M

“…To study the laboratory diagnosis of tuberculosis (TB), and relate the findings to its epidemiology in Central Saudi Arabia. This retrospective study was…”
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In vitro anti-mycobacterial activities of various 2'-deoxyuridine, 2'-arabinouridine and 2'-arabinofluoro-2'-deoxyuridine analogues: synthesis and biological studies by Srivastav, Naveen C, Manning, Tracey, Kunimoto, Dennis Y, Kumar, Rakesh

“…M. tuberculosis, M. bovis and M. avium infections cause the most important mycobacterioses leading to increased mortality in patients with AIDS. Various…”
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Transplantation in the face of severe donor sepsis: pushing the boundaries? by Pauly, Robert P, Rayner, David, Murray, Allan G, Gilmour, Susan M, Kunimoto, Dennis Y

“…Most current transplantation guidelines suggest that bacteremia or bacterial sepsis precludes organ donation. However, various investigators report good…”
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IS1626, a new IS900-related Mycobacterium avium insertion sequence by Puyang, Xiaoling, Lee, Karen, Pawlichuk, Corey, Kunimoto, Dennis Y

“…Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada T6G 2H7 1 Author for correspondence: Dennis Y. Kunimoto. Tel: +1 780…”
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Harnessing Innate Immunity to Treat IMycobacterium tuberculosis/I Infections: Heat-Killed ICaulobacter crescentus/I as a Novel Biotherapeutic by Gupta, Nancy, Vedi, Satish, Garg, Saurabh, Loo, Eric, Li, Jie, Kunimoto, Dennis Y, Kumar, Rakesh, Agrawal, Babita

“…Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a serious and devastating infectious disease worldwide. Approximately a quarter of the world…”
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Chapitre 3: Le diagnostic de la tuberculose active et de la tuberculose pharmacorésistante by Behr, Marcel A., Lapierre, Simon Grandjean, Kunimoto, Dennis Y., Lee, Robyn S., Long, Richard, Sekirov, Inna, Soualhine, Hafid, Turenne, Christine Y.

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