Search Results - "Kunikawa, Shigeki"

Discovery of 2,4-diamino-5-cyanopyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions by Kunikawa, Shigeki, Tanaka, Akira, Takasuna, Yuji, Tasaki, Mamoru, Chida, Noboru

“…[Display omitted] Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as…”
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A novel 2,4-diaminopyrimidine derivative as selective inhibitor of protein kinase C theta prevents allograft rejection in a rat heart transplant model by Kunikawa, Shigeki, Tanaka, Akira, Takasuna, Yuji, Tasaki, Mamoru, Chida, Noboru

“…[Display omitted] Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and is an attractive target for the treatment of T cell-mediated…”
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Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug–drug interactions and P-gp liability by Kunikawa, Shigeki, Tanaka, Akira, Mukoyoshi, Koichiro, Nagashima, Shinya, Tominaga, Hiroaki, Chida, Noboru, Tasaki, Mamoru, Shirai, Fumiyuki

“…[Display omitted] Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as…”
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Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3 by Nakajima, Yutaka, Inoue, Takayuki, Nakai, Kazuo, Mukoyoshi, Koichiro, Hamaguchi, Hisao, Hatanaka, Keiko, Sasaki, Hiroshi, Tanaka, Akira, Takahashi, Fumie, Kunikawa, Shigeki, Usuda, Hiroyuki, Moritomo, Ayako, Higashi, Yasuyuki, Inami, Masamichi, Shirakami, Shohei

“…[Display omitted] Janus kinases (JAKs) regulate various inflammatory and immune responses and are targets for the treatment of inflammatory and immune…”
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Co(III)−Alkyl Complex- and Co(III)−Alkylperoxo Complex-Catalyzed Triethylsilylperoxidation of Alkenes with Molecular Oxygen and Triethylsilane by Tokuyasu, Takahiro, Kunikawa, Shigeki, Masuyama, Araki, Nojima, Masatomo

“…Both a Co(III)−alkyl complex and a Co(III)−alkylperoxo complex were found to catalyze triethylsilylperoxidation of alkenes with O2 and Et3SiH. On this basis,…”
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Corrigendum to “Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3” [Bioorg. Med. Chem. 23 (2015) 4871–4883] by Nakajima, Yutaka, Inoue, Takayuki, Nakai, Kazuo, Mukoyoshi, Koichiro, Hamaguchi, Hisao, Hatanaka, Keiko, Sasaki, Hiroshi, Tanaka, Akira, Takahashi, Fumie, Kunikawa, Shigeki, Usuda, Hiroyuki, Moritomo, Ayako, Higashi, Yasuyuki, Inami, Masamichi, Shirakami, Shohei

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Corrigendum to “Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3” [Bioorg. Med. Chem. 23 (2015) 4871–4883] by Nakajima, Yutaka, Inoue, Takayuki, Nakai, Kazuo, Mukoyoshi, Koichiro, Hamaguchi, Hisao, Hatanaka, Keiko, Sasaki, Hiroshi, Tanaka, Akira, Takahashi, Fumie, Kunikawa, Shigeki, Usuda, Hiroyuki, Moritomo, Ayako, Higashi, Yasuyuki, Inami, Masamichi, Shirakami, Shohei

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Synthesis of Cyclic Peroxides by Chemo- and Regioselective Peroxidation of Dienes with Co(II)/O2/Et3SiH by Tokuyasu, Takahiro, Kunikawa, Shigeki, McCullough, Kevin J, Masuyama, Araki, Nojima, Masatomo

“…In the competitive peroxidation of mixtures of two alkenes with Co(II)/O2/Et3SiH, it was found that the relative reactivities of the alkene substrates are…”
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Synthesis of Antimalarial Yingzhaosu A Analogues by the Peroxidation of Dienes with Co(II)/O2/Et3SiH by Tokuyasu, Takahiro, Kunikawa, Shigeki, Abe, Manabu, Masuyama, Araki, Nojima, Masatomo, Kim, Hye-Sook, Begum, Khurshida, Wataya, Yusuke

“…Co(II)-catalyzed peroxidation of dienes including (S)-limonene in the presence of molecular oxygen and triethylsilane provided in each case the corresponding…”
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Co-catalyzed autoxidation of alkene in the presence of silane. The effect of the structure of silanes on the efficiency of the reaction and on the product distribution by Wu, Jin-Ming, Kunikawa, Shigeki, Tokuyasu, Takahiro, Masuyama, Araki, Nojima, Masatomo, Kim, Hye-Sook, Wataya, Yusuke

“…A systematic investigation of the structural effect of silanes on the Co-catalyzed reductive oxygenation of alkene in the presence of silane (Mukaiyama–Isayama…”
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Synthesis of cyclic peroxides by chemo- and regioselective peroxidation of dienes with Co(II)/O2Et3SiH by TOKUYASU, Takahiro, KUNIKAWA, Shigeki, MCCULLOUGH, Kevin J, MASUYAMA, Araki, NOJIMA, Masatomo

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Synthesis of Cyclic Peroxides by Chemo- and Regioselective Peroxidation of Dienes with Co(II)/O 2 /Et 3 SiH by Tokuyasu, Takahiro, Kunikawa, Shigeki, McCullough, Kevin J., Masuyama, Araki, Nojima, Masatomo

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Synthesis of Antimalarial Yingzhaosu A Analogues by the Peroxidation of Dienes with Co(II)/O 2 /Et 3 SiH by Tokuyasu, Takahiro, Kunikawa, Shigeki, Abe, Manabu, Masuyama, Araki, Nojima, Masatomo, Kim, Hye-Sook, Begum, Khurshida, Wataya, Yusuke

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