Search Results - "Kunicki, T"

Aspirin resistance: position paper of the Working Group on Aspirin Resistance by MICHELSON, A. D., CATTANEO, M., EIKELBOOM, J. W., GURBEL, P., KOTTKE‐MARCHANT, K., KUNICKI, T. J., PULCINELLI, F. M., CERLETTI, C., RAO, A. K.

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Platelet function defects by SIMON, D., KUNICKI, T., NUGENT, D.

“…Inherited defects of platelet function are a heterogeneous group of disorders that can result in bleeding symptoms ranging from mild bruising to severe…”
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Genetics of platelet reactivity in normal, healthy individuals by KUNICKI, T. J., WILLIAMS, S. A., SALOMON, D. R., HARRISON, P., CRISLER, P., NAKAGAWA, P., MONDALA, T. S., HEAD, S. R., NUGENT, D. J.

“…Background: The Platelet Function Analyzer‐100 (PFA‐100) is widely used to measure platelet reactivity in whole blood under high shear. Objective: To…”
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Mutation analysis for a patient with Glanzmann thrombasthenia who produced a landmark isoantibody to the αIIbβ3 integrin by NURDEN, A. T., KUNICKI, T., NURDEN, P., FIORE, M., MARTINS, N., HEILIG, R., PILLOIS, X.

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Association of the Platelet Glycoprotein Ia C807T Gene Polymorphism With Nonfatal Myocardial Infarction in Younger Patients by Santoso, S., Kunicki, T.J., Kroll, H., Haberbosch, W., Gardemann, A.

“…Recently, we have shown that two alleles of the glycoprotein (GP) Ia gene, designated C807 and T807, are associated with low or high platelet GPIa-IIa density…”
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The Function of Multiple Extracellular Matrix Receptors in Mediating Cell Adhesion to Extracellular Matrix: Preparation of Monoclonal Antibodies to the Fibronectin Receptor That Specifically Inhibit Cell Adhesion to Fibronectin and React with Platelet Glycoproteins Ic-IIa by Wayner, Elizabeth A., Carter, William G., Piotrowicz, Randolph S., Kunicki, Thomas J.

“…We have identified monoclonal antibodies that inhibit human cell adhesion to collagen (P1H5), fibronectin (P1F8 or P1D6), and collagen and fibronectin (P1B5)…”
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Effect of multimer size and a natural dimorphism on the binding of convulxin to platelet glycoprotein (GP)VI by KATO, K., FURIHATA, K., CHELI, Y., RADIS‐BAPTISTA, G., KUNICKI, T. J.

“…Background: Convulxin (CVX), a C‐type lectin from the venom of Crotalus durissusterrificus, is a potent activator of human platelets, binding predominantly to…”
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The molecular immunology of human platelet proteins by KUNICKI, T. J, NEWMAN, P. J

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An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees by KUNICKI, T. J., BARONCIANI, L., CANCIANI, M. T., GIANNIELLO, F., HEAD, S. R., MONDALA, T. S., SALOMON, D. R., FEDERICI, A. B.

“…We analyzed the association of bleeding severity with candidate gene haplotypes within pedigrees of 11 index cases of von Willebrand disease (VWD) type 2 (two…”
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Defective Dimerization of Von Willebrand Factor Subunits Due to a Cys → Arg Mutation in Type IID Von Willebrand Disease by Schneppenheim, R., Brassard, J., Krey, S., Budde, U., Kunicki, T. J., Holmberg, L., Ware, J., Ruggeri, Z. M.

“…The same heterozygous T → C transition at nt 8567 of the von Willebrand factor (vWF) transcript was found in two unrelated patients with type IID von…”
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Analysis of platelet membrane glycoprotein polymorphisms in Glanzmann thrombasthenia showed the French gypsy mutation in the αIIb gene to be strongly linked to the HPA‐1b polymorphism in β3 by Jacquelin, B., Tuleja, E., Kunicki, T. J., Nurden, P., Nurden, A. T.

“…We have tested the DNA of a large series of Glanzmann thrombasthenia patients for polymorphisms in platelet membrane glycoproteins. To our surprise, we noted a…”
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Platelet surface glycoproteins: studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery by GEORGE, J. N, PICKETT, E. B, SAUCERMAN, S, MCEVER, R. P, KUNICKI, T. J, KIEFFER, N, NEWMAN, P. J

“…The accurate definition of surface glycoprotein abnormalities in circulating platelets may provide better understanding of bleeding and thrombotic disorders…”
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The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex by Kunicki, T J, Nugent, D J, Staats, S J, Orchekowski, R P, Wayner, E A, Carter, W G

“…A monoclonal antibody, P1H5, to the human fibroblast class II extracellular matrix receptor (ECMR II) specifically inhibits human fibroblast adhesion to…”
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Platelet collagen receptors and risk prediction in stroke and coronary artery disease by Kunicki, T J, Ruggeri, Z M

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Variation in Human Platelet Glycoprotein VI Content Modulates Glycoprotein VI–Specific Prothrombinase Activity by Furihata, Kenichi, Clemetson, Kenneth J, Deguchi, Hiroshi, Kunicki, Thomas J

“…Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen that figures prominently in signal transduction. An addition to binding to type I and III…”
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Convulxin Binds to Native, Human Glycoprotein Ibα by Kanaji, Sachiko, Kanaji, Taisuke, Furihata, Kenichi, Kato, Kazunobu, Ware, Jerry L., Kunicki, Thomas J.

“…Convulxin (CVX), a C-type snake protein from Crotalus durissus terrificus venom, is the quintessential agonist for studies of the collagen receptor,…”
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Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets by Pidard, D, Montgomery, R R, Bennett, J S, Kunicki, T J

“…A murine monoclonal antibody, designated AP-2, reacts specifically with the complex formed by human platelet membrane glycoproteins IIb and IIIa, but does not…”
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Response of Human Platelets to Activating Monoclonal Antibodies: Importance of FCγRII (CD32) Phenotype and Level of Expression by Tomiyama, Yoshiaki, Kunicki, Thomas J., Zipf, Theodore F., Ford, Sheila B., Aster, Richard H.

“…Certain monoclonal antibodies (MoAbs) specific for platelet membrane glycoproteins are known to be capable of activating platelets, and it is generally thought…”
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Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites by Smith, J W, Ruggeri, Z M, Kunicki, T J, Cheresh, D A

“…Glycoprotein (GP) IIb-IIIa is the major fibrinogen receptor on platelets and participates in platelet aggregation at the site of a wound. Integrin alpha v beta…”
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Localization of human platelet autoantigens to the cysteine-rich region of glycoprotein IIIa by KEKOMAKIR, DAWSON, B, MCFARLAND, J, KUNICKI, T. J

“…The object of this study was to further localize autoantigenic structures on IIb-IIIa and, if possible, to precisely identify the epitopes recognized by human…”
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