Search Results - "Kung, Sam K.P."

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  1. 1

    A novel role of the scaffolding protein JLP in tuning CD40-induced activation of dendritic cells by Wang, Huiming, Zhao, Chongbo, Zhang, Manli, Lee, Clement M, Reddy, E. Premkumar, Kung, Sam K.P

    Published in Immunobiology (1979) (01-06-2013)
    “…Abstract Receptor internalization is a common mechanism underlying surface receptor down-regulation (and thus receptor signaling) upon its engagement with the…”
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  2. 2

    The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s by Sheppard, Sam, Schuster, Iona S., Andoniou, Christopher E., Cocita, Clement, Adejumo, Thomas, Kung, Sam K.P., Sun, Joseph C., Degli-Esposti, Mariapia A., Guerra, Nadia

    Published in Cell reports (Cambridge) (27-03-2018)
    “…TRAIL is an apoptosis-inducing ligand constitutively expressed on liver-resident type 1 innate lymphoid cells (ILC1s) and a subset of natural killer (NK)…”
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  3. 3

    A Conserved Serine of Heterogeneous Nuclear Ribonucleoprotein L (hnRNP L) Mediates Depolarization-regulated Alternative Splicing of Potassium Channels by Liu, Guodong, Razanau, Aleh, Hai, Yan, Yu, Jiankun, Sohail, Muhammad, Lobo, Vincent G., Chu, Jiayou, Kung, Sam K.P., Xie, Jiuyong

    Published in The Journal of biological chemistry (29-06-2012)
    “…Molecular mechanisms of gene regulation underlying the activity-dependent long term changes of cellular electrical properties, such as those during memory, are…”
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  4. 4

    Microfluidic-Based Live-Cell Analysis of NK Cell Migration In Vitro by Nandagopal, Saravanan, Lin, Francis, Kung, Sam K P

    “…Effector functions and cellular properties of natural killer (NK) cells are regulated by cellular and extracellular factors shaped by the microenvironments. NK…”
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  5. 5

    Scaffold Protein JLP Is Critical for CD40 Signaling in B Lymphocytes by Wang, Hui-ming, Yan, Qi, Yang, Tao, Cheng, Hui, Du, Juan, Yoshioka, Katsuji, Kung, Sam K.P., Ding, Guo-hua

    Published in The Journal of biological chemistry (27-02-2015)
    “…CD40 expression on the surface of B lymphocytes is essential for their biological function and fate decision. The engagement of CD40 with its cognate ligand,…”
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  6. 6

    Optimization and Functional Effects of Stable Short Hairpin RNA Expression in Primary Human Lymphocytes via Lentiviral Vectors by An, Dong Sung, Qin, F Xiao-Feng, Auyeung, Vincent C, Mao, Si Hua, Kung, Sam K P, Baltimore, David, Chen, Irvin S Y

    Published in Molecular therapy (01-10-2006)
    “…Specific, potent, and sustained short hairpin RNA (shRNA)-mediated gene silencing is crucial for the successful application of RNA interference technology to…”
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  7. 7

    The Heterogeneous Nuclear Ribonucleoprotein L Is an Essential Component in the Ca2+/Calmodulin-dependent Protein Kinase IV-regulated Alternative Splicing through Cytidine-Adenosine Repeats by Yu, Jiankun, Hai, Yan, Liu, Guodong, Fang, Tielan, Kung, Sam K.P., Xie, Jiuyong

    Published in The Journal of biological chemistry (16-01-2009)
    “…The regulation of gene expression through alternative pre-mRNA splicing is common in metazoans and is often controlled by intracellular signaling pathways that…”
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  8. 8

    Lentiviral vector-based therapy in head and neck cancer (Review) by UPRETI, DEEPAK, PATHAK, ALOK, KUNG, SAM K.P

    Published in Oncology letters (01-01-2014)
    “…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common neoplasm worldwide. Despite advances in multimodality treatments involving surgery,…”
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  9. 9

    Altering the specificity of NK:target cell interactions by genetic manipulation of NK receptor expression on primary mouse NK cells by Tran, Jimmy, Mahmood, Sajid, Carlyle, James R, Kung, Sam K.P

    Published in Vaccine (14-05-2010)
    “…Abstract A balance of signals generated via stimulatory and inhibitory NK receptors determines both target cell specificity and the outcome of NK–target cell…”
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  10. 10

    Induction of transgene-specific immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells by Kung, Sam K.P, An, Dong-Sung, Bonifacino, Aylin, Metzger, Mark E, Ringpis, Gene-Errol, Mao, Si-Hua, Chen, Irvin S.Y, Donahue, Robert E

    Published in Molecular therapy (01-12-2003)
    “…Modeling human hematopoietic progenitor cell gene therapy in nonhuman primates allows long-term evaluation of safety, maintenance of gene expression, and…”
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  11. 11

    A Missing Link: Engagements of Dendritic Cells in the Pathogenesis of SARS-CoV-2 Infections by Alamri, Abdulaziz, Fisk, Derek, Upreti, Deepak, Kung, Sam K P

    “…Dendritic cells (DC) connect the innate and adaptive arms of the immune system and carry out numerous roles that are significant in the context of viral…”
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  12. 12

    NK Cells Are Critical for Optimal Immunity to Experimental Trypanosoma congolense Infection by Onyilagha, Chukwunonso, Kuriakose, Shiby, Ikeogu, Nnamdi, Kung, Sam K P, Uzonna, Jude E

    Published in The Journal of immunology (1950) (15-08-2019)
    “…NK cells are key innate immune cells that play critical roles in host defense. Although NK cells have been shown to regulate immunity to some infectious…”
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  13. 13

    Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence by Movassagh, Hesam, Shan, Lianyu, Koussih, Latifa, Alamri, Abdulaziz, Ariaee, Nazila, Kung, Sam K. P., Gounni, Abdelilah S.

    Published in PloS one (29-06-2021)
    “…Regulation of dendritic cell functions is a complex process in which several mediators play diverse roles as a network in a context-dependent manner. The…”
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  14. 14
  15. 15

    Microfluidic‐based, live‐cell analysis allows assessment of NK‐cell migration in response to crosstalk with dendritic cells by Mahmood, Sajid, Nandagopal, Saravanan, Sow, Ibrahim, Lin, Francis, Kung, Sam K. P.

    Published in European journal of immunology (01-09-2014)
    “…Migration and localization of NK cells into peripheral tissues are tightly regulated under normal and pathological conditions. The physiological importance of…”
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  16. 16

    Differential cellular responses by oncogenic levels of c-Myc expression in long-term confluent retinal pigment epithelial cells by Wang, Yiping, Cheng, Xiangdong, Samma, Muhammad Kaleem, Kung, Sam K. P., Lee, Clement M., Chiu, Sung Kay

    Published in Molecular and cellular biochemistry (01-06-2018)
    “…c-Myc is a highly pleiotropic transcription factor known to control cell cycle progression, apoptosis, and cellular transformation. Normally, ectopic…”
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  17. 17

    Semaphorin-3E Produced by Immature Dendritic Cells Regulates Activated Natural Killer Cells Migration by Alamri, Abdulaziz, Rahman, Rahmat, Zhang, Manli, Alamri, Abeer, Gounni, Abdelilah S, Kung, Sam K P

    Published in Frontiers in immunology (09-05-2018)
    “…Natural killer (NK) cells and dendritic cells (DCs) are two innate immune cells that are critical in regulating innate and adaptive immunity. Cellular…”
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  18. 18

    Change in CD3ζ‐chain expression is an independent predictor of disease status in head and neck cancer patients by Upreti, Deepak, Zhang, Man‐li, Bykova, Elena, Kung, Sam K. P., Pathak, K. A.

    Published in International journal of cancer (01-07-2016)
    “…CD3ζ has emerged as a clinically important immunological marker in head and neck squamous cell carcinoma (HNSCC) with reduced level of expression reported in…”
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  19. 19

    View Point: Semaphorin-3E: An Emerging Modulator of Natural Killer Cell Functions? by Alamri, Abdulaziz, Soussi Gounni, Abdelilah, Kung, Sam K P

    “…Semaphorin-3E (Sema-3E) is a member of a large family of proteins originally identified as axon guidance cues in neural development. It is expressed in…”
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  20. 20

    Applications of microfluidic devices in advancing NK-cell migration studies by Ren, Xiaoou, Alamri, Abdulaziz, Hipolito, Jolly, Lin, Francis, Kung, Sam K P

    Published in Methods in enzymology (2020)
    “…Understanding how NK cells interact with tumor cells under specific microenvironment will be informative in development of NK-cell based immunotherapy…”
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