Search Results - "Kung, Sam K.P."
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A novel role of the scaffolding protein JLP in tuning CD40-induced activation of dendritic cells
Published in Immunobiology (1979) (01-06-2013)“…Abstract Receptor internalization is a common mechanism underlying surface receptor down-regulation (and thus receptor signaling) upon its engagement with the…”
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The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s
Published in Cell reports (Cambridge) (27-03-2018)“…TRAIL is an apoptosis-inducing ligand constitutively expressed on liver-resident type 1 innate lymphoid cells (ILC1s) and a subset of natural killer (NK)…”
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A Conserved Serine of Heterogeneous Nuclear Ribonucleoprotein L (hnRNP L) Mediates Depolarization-regulated Alternative Splicing of Potassium Channels
Published in The Journal of biological chemistry (29-06-2012)“…Molecular mechanisms of gene regulation underlying the activity-dependent long term changes of cellular electrical properties, such as those during memory, are…”
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Microfluidic-Based Live-Cell Analysis of NK Cell Migration In Vitro
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2016)“…Effector functions and cellular properties of natural killer (NK) cells are regulated by cellular and extracellular factors shaped by the microenvironments. NK…”
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Scaffold Protein JLP Is Critical for CD40 Signaling in B Lymphocytes
Published in The Journal of biological chemistry (27-02-2015)“…CD40 expression on the surface of B lymphocytes is essential for their biological function and fate decision. The engagement of CD40 with its cognate ligand,…”
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Optimization and Functional Effects of Stable Short Hairpin RNA Expression in Primary Human Lymphocytes via Lentiviral Vectors
Published in Molecular therapy (01-10-2006)“…Specific, potent, and sustained short hairpin RNA (shRNA)-mediated gene silencing is crucial for the successful application of RNA interference technology to…”
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The Heterogeneous Nuclear Ribonucleoprotein L Is an Essential Component in the Ca2+/Calmodulin-dependent Protein Kinase IV-regulated Alternative Splicing through Cytidine-Adenosine Repeats
Published in The Journal of biological chemistry (16-01-2009)“…The regulation of gene expression through alternative pre-mRNA splicing is common in metazoans and is often controlled by intracellular signaling pathways that…”
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Lentiviral vector-based therapy in head and neck cancer (Review)
Published in Oncology letters (01-01-2014)“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common neoplasm worldwide. Despite advances in multimodality treatments involving surgery,…”
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Altering the specificity of NK:target cell interactions by genetic manipulation of NK receptor expression on primary mouse NK cells
Published in Vaccine (14-05-2010)“…Abstract A balance of signals generated via stimulatory and inhibitory NK receptors determines both target cell specificity and the outcome of NK–target cell…”
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Induction of transgene-specific immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells
Published in Molecular therapy (01-12-2003)“…Modeling human hematopoietic progenitor cell gene therapy in nonhuman primates allows long-term evaluation of safety, maintenance of gene expression, and…”
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A Missing Link: Engagements of Dendritic Cells in the Pathogenesis of SARS-CoV-2 Infections
Published in International journal of molecular sciences (23-01-2021)“…Dendritic cells (DC) connect the innate and adaptive arms of the immune system and carry out numerous roles that are significant in the context of viral…”
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NK Cells Are Critical for Optimal Immunity to Experimental Trypanosoma congolense Infection
Published in The Journal of immunology (1950) (15-08-2019)“…NK cells are key innate immune cells that play critical roles in host defense. Although NK cells have been shown to regulate immunity to some infectious…”
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Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence
Published in PloS one (29-06-2021)“…Regulation of dendritic cell functions is a complex process in which several mediators play diverse roles as a network in a context-dependent manner. The…”
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Microfluidic‐based, live‐cell analysis allows assessment of NK‐cell migration in response to crosstalk with dendritic cells
Published in European journal of immunology (01-09-2014)“…Migration and localization of NK cells into peripheral tissues are tightly regulated under normal and pathological conditions. The physiological importance of…”
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Differential cellular responses by oncogenic levels of c-Myc expression in long-term confluent retinal pigment epithelial cells
Published in Molecular and cellular biochemistry (01-06-2018)“…c-Myc is a highly pleiotropic transcription factor known to control cell cycle progression, apoptosis, and cellular transformation. Normally, ectopic…”
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Semaphorin-3E Produced by Immature Dendritic Cells Regulates Activated Natural Killer Cells Migration
Published in Frontiers in immunology (09-05-2018)“…Natural killer (NK) cells and dendritic cells (DCs) are two innate immune cells that are critical in regulating innate and adaptive immunity. Cellular…”
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Change in CD3ζ‐chain expression is an independent predictor of disease status in head and neck cancer patients
Published in International journal of cancer (01-07-2016)“…CD3ζ has emerged as a clinically important immunological marker in head and neck squamous cell carcinoma (HNSCC) with reduced level of expression reported in…”
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View Point: Semaphorin-3E: An Emerging Modulator of Natural Killer Cell Functions?
Published in International journal of molecular sciences (05-11-2017)“…Semaphorin-3E (Sema-3E) is a member of a large family of proteins originally identified as axon guidance cues in neural development. It is expressed in…”
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Applications of microfluidic devices in advancing NK-cell migration studies
Published in Methods in enzymology (2020)“…Understanding how NK cells interact with tumor cells under specific microenvironment will be informative in development of NK-cell based immunotherapy…”
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