Search Results - "Kung, Ryan W."

Anatomy of noncovalent interactions between the nucleobases or ribose and π-containing amino acids in RNA–protein complexes by Wilson, Katie A, Kung, Ryan W, D’souza, Simmone, Wetmore, Stacey D

“…Abstract A set of >300 nonredundant high-resolution RNA–protein complexes were rigorously searched for π-contacts between an amino acid side chain (W, H, F, Y,…”
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Effect of Guanine Adduct Size, Shape, and Linker Type on the Conformation of Adducted DNA: A DFT and Molecular Dynamics Study by Jeong, Ye Eun Rebecca, Kung, Ryan W., Bykowski, Janelle, Deak, Trinity K., Wetmore, Stacey D.

“…DNA is damaged through various exogenous sources (e.g., automobile exhaust, tobacco smoke, and processed foods), which can yield diverse C8-dG bulky aryl…”
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Effects of a Second Local DNA Damage Event on the Toxicity of the Human Carcinogen 4‑Aminobiphenyl: A Molecular Dynamics Study of a Damaged DNA Structure by Kung, Ryan W, Takyi, Nathania A, Wetmore, Stacey D

“…Exposure of humans to carcinogenic aromatic amines (AAs) occurs daily. AAs are bioactivated in cells into products that attack DNA, primarily leading to…”
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Effect of Size and Shape of Nitrogen-Containing Aromatics on Conformational Preferences of DNA Containing Damaged Guanine by Kung, Ryan W, Sharma, Purshotam, Wetmore, Stacey D

“…The present work investigates the effects of the size and shape of the nitrogen-containing aromatic (NCA) skeleton on the structure of DNA damaged through…”
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Impact of DNA Adduct Size, Number, and Relative Position on the Toxicity of Aromatic Amines: A Molecular Dynamics Case Study of AN dG- and AP dG-Containing DNA Duplexes by Kung, Ryan W, Deak, Trinity K, Griffith-Salik, Cassidy A, Takyi, Nathania A, Wetmore, Stacey D

“…Human exposure to aromatic amines (AAs) can result in carcinogenic DNA adducts. To complement previous work geared toward understanding the mutagenicity of…”
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Structure of an Unusual Tetracyclic Deoxyguanosine Adduct: Implications for Frameshift Mutagenicity of ortho-Cyano Nitroanilines by Manning, Trevor W, Al-Abdul-Wahid, M. Sameer, Manderville, Richard A, Josephy, P. David, Kung, Ryan W, Wetmore, Stacey D

“…Nitroaromatic compounds represent a major class of industrial chemicals that are also found in nature. Polycyclic derivatives are regarded as potent mutagens…”
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Conformational Preference and Fluorescence Response of a C‑Linked C8-Biphenyl-Guanine Lesion in the NarI Mutational Hotspot: Evidence for Enhanced Syn Adduct Formation by Berger, Florence D, Sturla, Shana J, Kung, Ryan W, Montina, Tony, Wetmore, Stacey D, Manderville, Richard A

“…Aromatic chemical carcinogens can undergo enzymatic transformations to produce a range of electrophilic species that attach covalently to the C8-site of…”
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Fluorescent Nucleobase Analogues with Extended Pi Surfaces Stabilize DNA Duplexes Containing O6‐Alkylguanine Adducts by Dahlmann, Heidi A., Berger, Florence D., Kung, Ryan W., Wyss, Laura A., Gubler, Irina, McKeague, Maureen, Wetmore, Stacey D., Sturla, Shana J.

“…Chemical alkylation of DNA produces potentially toxic and mutagenic damage such as O6‐alkylguanine (O6‐alkylG) adducts. Non‐natural nucleoside analogues that…”
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Landscape of π-π and sugar-π contacts in DNA-protein interactions by Wilson, Katie A., Wells, Rachael A., Abendong, Minette N., Anderson, Colin B., Kung, Ryan W., Wetmore, Stacey D.

“…There were 1765 contacts identified between DNA nucleobases or deoxyribose and cyclic (W, H, F, Y) or acyclic (R, E, D) amino acids in 672 X-ray structures of…”
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Impact of DNA Adduct Size, Number, and Relative Position on the Toxicity of Aromatic Amines: A Molecular Dynamics Case Study of ANdG- and APdG-Containing DNA Duplexes by Kung, Ryan W, Deak, Trinity K, Griffith-Salik, Cassidy A, Takyi, Nathania A, Wetmore, Stacey D

“…Human exposure to aromatic amines (AAs) can result in carcinogenic DNA adducts. To complement previous work geared toward understanding the mutagenicity of…”
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Conformational Preference and Fluorescence Response of a C-Linked C8-Biphenyl-Guanine Lesion in the Nar I Mutational Hotspot: Evidence for Enhanced Syn Adduct Formation by Berger, Florence D., Sturla, Shana J., Kung, Ryan W., Montina, Tony, Wetmore, Stacey D., Manderville, Richard A.

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Fluorescent Nucleobase Analogues with Extended Pi Surfaces Stabilize DNA Duplexes Containing O 6 ‐Alkylguanine Adducts by Dahlmann, Heidi A., Berger, Florence D., Kung, Ryan W., Wyss, Laura A., Gubler, Irina, McKeague, Maureen, Wetmore, Stacey D., Sturla, Shana J.

“…Chemical alkylation of DNA produces potentially toxic and mutagenic damage such as O 6 ‐alkylguanine ( O 6 ‐alkylG) adducts. Non‐natural nucleoside analogues…”
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