Search Results - "Kung, John T."

A novel trivalent non-Fc anti-CD3 Collabody preferentially induces Th1 cell apoptosis in vitro and long-lasting remission in recent-onset diabetic NOD mice by Huang, Chuan-Chuan, Sung, Hsiang-Hsuan, Li, Hsiu-Chuan, Miaw, Shi-Chuen, Kung, John T., Chou, Min-Yuan, Wu-Hsieh, Betty A.

“…Specific anti-CD3 treatment is deemed to be a promising therapy for allograft rejection and type 1 diabetes (T1D). Fc receptor (FcR) reduced-binding…”
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Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers by Hwang-Verslues, Wendy W, Kuo, Wen-Hung, Chang, Po-Hao, Pan, Chi-Chun, Wang, Hsing-Hui, Tsai, Sheng-Ta, Jeng, Yung-Ming, Shew, Jin-Yu, Kung, John T, Chen, Chung-Hsuan, Lee, Eva Y-H P, Chang, King-Jen, Lee, Wen-Hwa

“…Heterogeneity of cancer stem/progenitor cells that give rise to different forms of cancer has been well demonstrated for leukemia. However, this fundamental…”
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Both Virus and Tumor Necrosis Factor Alpha Are Critical for Endothelium Damage in a Mouse Model of Dengue Virus-Induced Hemorrhage by Chen, Hsuen-Chin, Hofman, Florence M, Kung, John T, Lin, Yang-Ding, Wu-Hsieh, Betty A

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Immunization with Apoptotic Phagocytes Containing Histoplasma capsulatum Activates Functional CD8+ T Cells To Protect against Histoplasmosis by HSIEH, Shih-Hung, LIN, Jr-Shiuan, HUANG, Juin-Hua, WU, Shang-Yang, CHU, Ching-Liang, KUNG, John T, WU-HSIEH, Betty A

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CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells by Lai, Yo-Ping, Kuo, Lu-Cheng, Lin, Been-Ren, Lin, Hung-Ju, Lin, Chih-Yu, Chen, Yi-Ting, Hsiao, Pei-Wen, Chang, Huan-Tsung, Ko, Patrick Chow-In, Chen, Hsiao-Chin, Chang, Hsiang-Yu, Lu, Jean, Ho, Hong-Nerng, Wu-Hsieh, Betty A., Kung, John T., Chen, Shu-Ching

“…CD28 is required for T cell activation as well as the generation of CD4 + Foxp3 + Treg. It is unclear, however, how CD28 costimulation affects the development…”
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Rapid Death of Follicular B Cells and Burkitt Lymphoma Cells Effectuated by Xbp1s by Chen, Yi-Ting, Kung, John T

“…BCR-mediated tonic signaling is an indispensable requirement for the survival of follicular B (FOB) cells and Burkitt lymphoma (BL) cells. FOB cells of the I-A…”
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CD8 + T cell memory is sustained in mice by hepatic stellate cells by Chen, Yi-Ting, Su, Yu-Chia, Or, Yee-Ern, Cheng, Chin-Fu, Kung, John T

“…Long-lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8 + cytotoxic T cells (MemCD8TCs) is thought to be…”
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B Cell Development sans B Cell Receptor Responsiveness Due to Unfolded Protein Response-Triggered Mef2c Protein Degradation by Chen, Yi-Ting, Su, Yu-Chia, Kung, John T

“…BCR engagement leads to activation and clonal expansion of B cells. The I-A mutant mouse possesses a branch site point mutation in the gene that causes highly…”
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Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility by Lee, Chen-Cheng, Kung, John T

“…Rag-1-knockout (KO) mice are highly resistant to Listeria monocytogenes infection. The role played by the many Rag-1-dependent lymphocyte lineages was studied…”
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STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria by Chen, Ting-Ting, Tsai, Ming-Hsun, Kung, John T, Lin, Kuo-I, Decker, Thomas, Lee, Chien-Kuo

“…Marginal zone B (MZ B) cells can rapidly produce antibody in response to infection with blood-borne encapsulated pathogens. Although TLR-mediated activation of…”
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Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice by Zheng, Lingjie, Sharma, Rahul, Kung, John T., Deshmukh, Umesh S., Jarjour, Wael N., Fu, Shu Man, Ju, Shyr-Te

“…We hypothesize that regulatory T-cell (Treg)-deficient strains have an altered TCR repertoire in part due to the expansion of autoimmune repertoire by…”
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Potent Induction of Long-Term CD8+T Cell Memory by Short-Term IL-4 Exposure during T Cell Receptor Stimulation by Huang, Li-Rung, Chen, Fen-Ling, Chen, Yi-Ting, Lin, Ya-Min, Kung, John T.

“…An important goal of vaccination is to achieve long-term survival of functional memory T cells. Using a MHC-compatible adoptive transfer system, we show here…”
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Low-Level MHC Class II Expression Leads to Suboptimal Th Cell Response, Increased Autoaggression, and Heightened Cytokine Inducibility by Chen, Yi-Ting, Su, Yu-Chia, Chang, Mei-Ling, Tsai, Pi-Fang, Kung, John T

“…The development and activation of MHC class II (MHC-II)-restricted CD4 T cells are distinct immunological processes that are strictly MHC-II-dependent. To…”
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The Biology of Autoimmune Response in the Scurfy Mice that Lack the CD4+Foxp3+ Regulatory T-Cells by Ju, Shyr-Te, Sharma, Rahul, Gaskin, Felicia, Kung, John T, Fu, Shu Man

“…Due to a mutation in the Foxp3 transcription factor, Scurfy mice lack regulatory T-cells that maintain self-tolerance of the immune system. They develop…”
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Immunodeficient mouse models with different disease profiles by in vivo infection with the same clinical isolate of enterovirus 71 by Liao, Chun-Che, Liou, An-Ting, Chang, Ya-Shu, Wu, Szu-Yao, Chang, Chih-Shin, Lee, Chien-Kuo, Kung, John T, Tu, Pang-Hsien, Yu, Ya-Yen, Lin, Chi-Yung, Lin, Jen-Shiou, Shih, Chiaho

“…Like poliovirus infection, severe infection with enterovirus 71 (EV71) can cause neuropathology. Unlike poliovirus, EV71 is often associated with…”
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The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection by Peng, Jung-Kuei, Lin, Jr-Shiuan, Kung, John T., Finkelman, Fred D., Wu-Hsieh, Betty A.

“…Dominant type-1 cytokine production is induced in a murine model of systemic histoplasmosis. We used this model to investigate whether the presence of…”
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An Alternatively Spliced IL-15 Isoform Modulates Abrasion-Induced Keratinocyte Activation by Lee, Tsung-Lin, Chang, Mei-Ling, Lin, Yu-Jei, Tsai, Ming-Hsun, Chang, Yi-Hsuan, Chuang, Che-Ming, Chien, Yun, Sosinowski, Tomasz, Wang, Chih-Hsiu, Chen, Yi-Yuan, Lee, Chien-Kuo, Chen, Jau-Shiuh, Wang, Li-Fang, Kung, John T., Ku, Chia-Chi

“…In a routine phenotype-driven screen, we identified a point mutation in exon 7 of the IL-15 gene in Pedigree 191 (deficient memory (DM)) of…”
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Effector function-deficient memory CD8+ T cells clonally expand in the liver and give rise to peripheral memory CD8+ T cells by Su, Yu-Chia, Lee, Chen-Cheng, Kung, John T

“…Upon adoptive transfer into histocompatible mice, naive CD8(+) T cells stimulated ex vivo by TCR+IL-4 turn into long-lived functional memory cells. The liver…”
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A novel ENU-induced neonatal death mutant mouse: Characterization and identification of responsible mutant gene by Ho, Chun-Ta, Kung, John T., Huang, Pei-Hsin

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Rapid and Selective Expansion of Nonclonotypic T Cells in Regulatory T Cell-Deficient, Foreign Antigen-Specific TCR-Transgenic Scurfy Mice: Antigen-Dependent Expansion and TCR Analysis by Sharma, Rahul, Ju, Angela Chiao-Ying, Kung, John T, Fu, Shu Man, Ju, Shyr-Te

“…Foreign Ag-specific TCR-transgenic (Tg) mice contain a small fraction of T cells bearing the endogenous Vbeta and Valpha chains as well as a population…”
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