Search Results - "Kunes, Jiri"

Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies by Mamun, Abdullah Al, Pidaný, Filip, Hulcová, Daniela, Maříková, Jana, Kučera, Tomáš, Schmidt, Monika, Catapano, Maria Carmen, Hrabinová, Martina, Jun, Daniel, Múčková, Lubica, Kuneš, Jiří, Janoušek, Jiří, Andrýs, Rudolf, Nováková, Lucie, Peřinová, Rozálie, Maafi, Negar, Soukup, Ondřej, Korábečný, Jan, Cahlíková, Lucie

“…Alzheimer’s disease (AD) is a multifactorial neurodegenerative condition of the central nervous system (CNS) that is currently treated by cholinesterase…”
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Novel pyrazine analogs of chalcones: synthesis and evaluation of their antifungal and antimycobacterial activity by Kucerova-Chlupacova, Marta, Kunes, Jiri, Buchta, Vladimir, Vejsova, Marcela, Opletalova, Veronika

“…Infectious diseases, such as tuberculosis and invasive mycoses, represent serious health problems. As a part of our long-term efforts to find new agents for…”
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Novel Halogenated Pyrazine-Based Chalcones as Potential Antimicrobial Drugs by Kucerova-Chlupacova, Marta, Vyskovska-Tyllova, Veronika, Richterova-Finkova, Lenka, Kunes, Jiri, Buchta, Vladimir, Vejsova, Marcela, Paterova, Pavla, Semelkova, Lucia, Jandourek, Ondrej, Opletalova, Veronika

“…Chalcones, i.e., compounds with the chemical pattern of 1,3-diphenylprop-2-en-1-ones, exert a wide range of bio-activities, e.g., antioxidant,…”
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Synthesis and antimicrobial evaluation of new 2-substituted 5,7-di- tert-butylbenzoxazoles by Vinsova, Jarmila, Cermakova, Katerina, Tomeckova, Alexandra, Ceckova, Martina, Jampilek, Josef, Cermak, Pavel, Kunes, Jiri, Dolezal, Martin, Staud, Frantisek

“…Various synthetic pathways of the 30 novel 2-substituted 5,7-di- tert-butylbenzoxazoles as new potential antimicrobial drugs are discussed. The 28…”
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Rhodanineacetic acid derivatives as potential drugs: preparation, hydrophobic properties and antifungal activity of (5-arylalkylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acids by Dolezel, Jan, Hirsova, Petra, Opletalova, Veronika, Dohnal, Jiri, Marcela, Vejsova, Kunes, Jiri, Jampilek, Josef

“…Some [(5Z)-(5-arylalkylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)]acetic acids were prepared as potential antifungal compounds. The general synthetic approach…”
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Synthesis, antimycobacterial, antifungal and photosynthesis-inhibiting activity of chlorinated N-phenylpyrazine-2-carboxamides by Dolezal, Martin, Zitko, Jan, Osicka, Zdenek, Kunes, Jiri, Vejsova, Marcela, Buchta, Vladimir, Dohnal, Jiri, Jampilek, Josef, Kralova, Katarina

“…A series of sixteen pyrazinamide analogues with the -CONH- linker connecting the pyrazine and benzene rings was synthesized by the condensation of chlorides of…”
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Synthesis and characterization of (Z)-5-arylmethylidene-rhodanines with photosynthesis-inhibiting properties by Opletalova, Veronika, Dolezel, Jan, Kralova, Katarina, Pesko, Matus, Kunes, Jiri, Jampilek, Josef

“…A series of rhodanine derivatives was prepared. The synthetic approach, analytical and spectroscopic data of all synthesized compounds are presented…”
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N-substituted 5-amino-6-methylpyrazine-2,3-dicarbonitriles: microwave-assisted synthesis and biological properties by Jandourek, Ondrej, Dolezal, Martin, Paterova, Pavla, Kubicek, Vladimir, Pesko, Matus, Kunes, Jiri, Coffey, Aidan, Guo, Jiahui, Kralova, Katarina

“…In this work a series of 15 N-benzylamine substituted 5-amino-6-methyl-pyrazine-2,3-dicarbonitriles was prepared by the aminodehalogenation reactions using…”
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Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides by Semelkova, Lucia, Konecna, Klara, Paterova, Pavla, Kubicek, Vladimir, Kunes, Jiri, Novakova, Lucie, Marek, Jan, Naesens, Lieve, Pesko, Matus, Kralova, Katarina, Dolezal, Martin, Zitko, Jan

“…A series of N-alkyl-3-(alkylamino)pyrazine-2-carboxamides and their N-alkyl-3-chloropyrazine-2-carboxamide precursors were prepared. All compounds were…”
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A Note on the Antitubercular Activities of 1-Aryl-5-benzylsulfanyltetrazoles by Adamec, Jan, Waisser, Karel, Kuneš, Jiří, Kaustová, Jarmila

“…A set of 32 1‐phenyl‐5‐benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was synthesized. The compounds were evaluated…”
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New potentially active pyrazinamide derivatives synthesized under microwave conditions by Jandourek, Ondrej, Dolezal, Martin, Kunes, Jiri, Kubicek, Vladimir, Paterova, Pavla, Pesko, Matus, Buchta, Vladimir, Kralova, Katarina, Zitko, Jan

“…A series of 18 N-alkyl substituted 3-aminopyrazine-2-carboxamides was prepared in this work according to previously experimentally set and proven conditions…”
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Azole Antimycotics Differentially Affect Rifampicin-Induced Pregnane X Receptor-Mediated CYP3A4 Gene Expression by SVECOVA, Lucie, VRZAL, Radim, ANZENBACHER, Pavel, DVORAK, Zdenek, PAVEK, Petr, BURYSEK, Ladislav, ANZENBACHEROVA, Eva, CERVENY, Lukas, GRIM, Jiri, TREJTNAR, Frantisek, KUNES, Jiri, POUR, Milan, STAUD, Frantisek

“…Azole antifungal drug ketoconazole has recently been demonstrated as an inhibitor of a ligand-induced pregnane X receptor (PXR)-mediated transcriptional…”
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N-Benzylsalicylthioamides: Highly Active Potential Antituberculotics by Doležal, Rafael, Waisser, Karel, Petrlíková, Eva, Kuneš, Jirí, Kubicová, Lenka, Machácek, Miloš, Kaustová, Jarmila, Dahse, Hans Martin

“…A gseries of 29 new derivatives of N‐benzylsalicylthioamides was synthesized and the compounds were tested for in‐vitro antimycobacterial activity against…”
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(Z)-3-Amino-5-(pyridin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one by Hirsova, Petra, Dolezel, Jan, Kucerova-Chlupacova, Marta, Kunes, Jiri, Pilarova, Veronika, Novakova, Lucie, Opletalova, Veronika

“…3-Aminorhodanine reacts with aldehydes to form either 5-[(aryl)alkylidene]-substituted products or Schiff bases or derivatives substituted at both the 3-amino…”
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Substituted Amides of Pyrazine-2-carboxylic acids: Synthesis and Biological Activity by Dolezal, Martin, Miletin, Miroslav, Kunes, Jiri, Kralova, Katarina

“…Condensation of 6-chloro-, 5-tert-butyl- or 6-chloro-5-tert-butylpyrazine-2-carboxylic acid chloride with ring substituted anilines yielded a series of amides,…”
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The Oriented Development of Antituberculotics (Part II): Halogenated 3-(4-Alkylphenyl)-1,3-benzoxazine-2,4-(3H)-diones by Waisser, Karel, Matyk, Josef, Divišová, Hana, Husáková, Petra, Kuneš, Jirí, Klimešová, Vera, Palát, Karel, Kaustová, Jarmila

“…Based on our previous studies, 21 new halogenated 3‐(4‐alkylphenyl)‐1,3‐benzoxazine‐2,4‐(3H)‐diones were synthesized by the reaction of salicylanilides and…”
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A simple method for the preparation of 5-alkylsulfinyl-1-aryltetrazoles by Hrabalek, Alexandr, Myznikov, Leonid, Kunes, Jiri, Vavrova, Katerina, Koldobskii, Grigorii

“…A simple method is suggested for the preparation of 5-alkylsulfinyl-1-aryltetrazoles via oxidation of 5-alkylsulfanyltetrazoles with 34% peracetic acid in high…”
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3-Benzyl-2H-1,3-benzoxazine-2,4(3H)-diones, a new group of antimycobacterial compounds against potentially pathogenic strains by WAISSER, Karel, PERINA, Milan, KUNES, Jiri, KLIMESOVA, Vera, KAUSTOVA, Jarmila

“…A series of derivatives of 3-benzyl-2H-benzoxazine-2,4(3H)-dione substituted in positions 6, 7 or 8 on the benzoxazine, and in positions 3 or 4 on the benzyl…”
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Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer’s Disease by Hostalkova, Anna, Marikova, Jana, Opletal, Lubomir, Korabecny, Jan, Hulcova, Daniela, Kunes, Jiri, Novakova, Lucie, Perez, Daniel I, Jun, Daniel, Kucera, Tomas, Andrisano, Vincenza, Siatka, Tomas, Cahlikova, Lucie

“…Three new alkaloids, bersavine (3), muraricine (4), and berbostrejdine (8), together with seven known isoquinoline alkaloids (1–2, 5–7, 9, and 10) were…”
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Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation by Pidany, Filip, Kroustkova, Jana, Al Mamun, Abdullah, Suchankova, Daniela, Brazzolotto, Xavier, Nachon, Florian, Chantegreil, Fabien, Dolezal, Rafael, Pulkrabkova, Lenka, Muckova, Lubica, Hrabinova, Martina, Finger, Vladimir, Kufa, Martin, Soukup, Ondrej, Jun, Daniel, Jenco, Jaroslav, Kunes, Jiri, Novakova, Lucie, Korabecny, Jan, Cahlikova, Lucie

“…Butyrylcholinesterase (BChE) is one of the most frequently implicated enzymes in the advanced stage of Alzheimer's disease (AD). As part of our endeavors to…”
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