Search Results - "Kundu, Chanakya Nath"

5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition by Sethy, Chinmayee, Kundu, Chanakya Nath

“…[Display omitted] •Primary cause of 5-FU resistance has been attributed to presence of cancer stem like cells (CSCs) within the cancer cells niche.•5-FU in…”
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Quinacrine and curcumin synergistically increased the breast cancer stem cells death by inhibiting ABCG2 and modulating DNA damage repair pathway by Nayak, Deepika, Tripathi, Neha, Kathuria, Deepika, Siddharth, Sumit, Nayak, Anmada, Bharatam, Prasad V., Kundu, Chanakya

“…[Display omitted] •Quinacrine and Curcumin synergistically caused apoptosis in breast cancer stem cell like cells (CSCs).•Quinacrine and Curcumin inhibit the…”
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Novel, selective acrylamide linked quinazolines for the treatment of double mutant EGFR-L858R/T790M Non-Small-Cell lung cancer (NSCLC) by Pawara, Rahul, Ahmad, Iqrar, Nayak, Deepika, Wagh, Shivani, Wadkar, Avinash, Ansari, Azim, Belamkar, Sateesh, Surana, Sanjay, Nath Kundu, Chanakya, Patil, Chandragauda, Patel, Harun

“…[Display omitted] •L858R/T790M mutation is the most common mechanism of acquired resistance.•Compounds 2i and 11h identified as lead compounds.•Compounds were…”
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Cancer-induced Pain Management by Nanotechnology-based Approach by Dash, Somya Ranjan, Kundu, Chanakya Nath

“…Cancer patients frequently report experiencing pain as one of their symptoms. Cancerrelated pain is often caused by the tumor itself, especially when the tumor…”
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The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4 by Siddharth, Sumit, Nayak, Anmada, Das, Sarita, Nayak, Deepika, Panda, Jyochanamayi, Wyatt, Michael D., Kundu, Chanakya Nath

“…•Using in vitro, in vivo, In Ovo and Ex vivo model system we have proved that a pvrl-4 encoded gene Nectin-4 has angiogenesis potentiality.•Nectin-4 is a…”
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Chitosan-Dextran sulfate coated doxorubicin loaded PLGA-PVA-nanoparticles caused apoptosis in doxorubicin resistance breast cancer cells through induction of DNA damage by Siddharth, Sumit, Nayak, Anmada, Nayak, Deepika, Bindhani, Birendra Kumar, Kundu, Chanakya Nath

“…To overcome the toxicity, pharmacokinetics and drug resistance associated with doxorubicin (DOX), a strategy was developed by encapsulating DOX-…”
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Improving the therapeutic window of anticancer agents by β-cyclodextrin encapsulation: Experimental and theoretical insights by Priyadarsini Mishra, Nilima, Kumar Sahoo, Dipak, Mohapatra, Seetaram, Nayak, Sabita, Nayak, Deepika, Nath Kundu, Chanakya

“…[Display omitted] •Prepared stable 1:1 inclusion complexes of hydrophobic anticancer drug MNC with β-cyclodextrin.•Comprehensive characterization confirmed…”
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Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity by Preet, Ranjan, Mohapatra, Purusottam, Mohanty, Suchitra, Sahu, Sushil Kumar, Choudhuri, Tathagata, Wyatt, Michael D., Kundu, Chanakya Nath

“…The small molecule Quinacrine (QC, a derivative of 9‐aminoacridine), an anti‐malaria drug, displays activity against cancer cell lines and can simultaneously…”
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Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse by Sethy, Chinmayee, Goutam, Kunal, Nayak, Deepika, Pradhan, Rajalaxmi, Molla, Sefinew, Chatterjee, Subhajit, Rout, Niranjan, Wyatt, Michael D., Narayan, Satya, Kundu, Chanakya Nath

“…Purpose In the present study, we have systematically examined the clinical significance of Nectin-4 (encoded by the PVRL - 4 gene), a marker for breast cancer…”
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Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53 by Satapathy, Shakti Ranjan, Mohapatra, Purusottam, Preet, Ranjan, Das, Dipon, Sarkar, Biplab, Choudhuri, Tathagata, Wyatt, Michael D, Kundu, Chanakya Nath

“…The authors have systematically investigated the anticancer potentiality of silver-based nanoparticles (AgNPs) and the mechanism underlying their biological…”
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NECTIN-4 increased the 5-FU resistance in colon cancer cells by inducing the PI3K–AKT cascade by Das, Dipon, Satapathy, Shakti Ranjan, Siddharth, Sumit, Nayak, Anmada, Kundu, Chanakya Nath

“…Purpose 5-Fluorouracil is the most commonly used drug for the treatment of colon cancer, yet clinical resistance to this drug is frequently observed in…”
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Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice by Gavhane, Swapnil, Gawli, Chandrakant, Kumar, Sachin, Das, Biswajit, Marathe, Gayatri, Patil, Vishal S, Patel, Harun M, Bommanahalli, Basavaraj, Kundu, Chanakya Nath, Patil, Chandragouda R

“…Objective: To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis (IPF) and to explore its underlying mechanisms using…”
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Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism by Mohapatra, Purusottam, Preet, Ranjan, Das, Dipon, Satapathy, Shakti Ranjan, Choudhuri, Tathagata, Wyatt, Michael D, Kundu, Chanakya Nath

“…We previously showed that quinacrine (QC), a small molecule antimalarial agent, also presented anticancer activity in breast cancer cells through activation of…”
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The contribution of heavy metals in cigarette smoke condensate to malignant transformation of breast epithelial cells and in vivo initiation of neoplasia through induction of a PI3K–AKT–NFκB cascade by Mohapatra, Purusottam, Preet, Ranjan, Das, Dipon, Satapathy, Shakti Ranjan, Siddharth, Sumit, Choudhuri, Tathagata, Wyatt, Michael D., Kundu, Chanakya Nath

“…Cigarette smoking is a crucial factor in the development and progression of multiple cancers including breast. Here, we report that repeated exposure to a…”
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5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway by Das, Dipon, Preet, Ranjan, Mohapatra, Purusottam, Satapathy, Shakti Ranjan, Siddharth, Sumit, Tamir, Tigist, Jain, Vaibhav, Bharatam, Prasad V., Wyatt, Michael D., Kundu, Chanakya Nath

“…•5-FU increased the expression of APC in colorectal cancer (CRC) cells.•Knockdown of APC in CRC caused resistance to 5-FU by removing APC's block of long-patch…”
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Temporal dynamics of oropharyngeal microbiome among SARS-CoV-2 patients reveals continued dysbiosis even after Viral Clearance by Paine, Suman Kalyan, Rout, Usha Kiran, Bhattacharyya, Chandrika, Parai, Debaprasad, Alam, Mahabub, Nanda, Rasmi Ranjan, Tripathi, Devashish, Choudhury, Parveena, Kundu, Chanakya Nath, Pati, Sanghamitra, Bhattacharya, Debdutta, Basu, Analabha

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has posed multiple challenges to global public health. Clinical features and sequela…”
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RETRACTED ARTICLE: Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS- mediated neuropathic pain in rats by Magar, Shital, Nayak, Deepika, Mahajan, Umesh B., Patil, Kalpesh R., Shinde, Sachin D., Goyal, Sameer N., Swaminarayan, Shivang, Patil, Chandragouda R., Ojha, Shreesh, Kundu, Chanakya Nath

“…Despite the availability of multiple therapeutic agents, the search for novel pain management of neuropathic pain is still a challenge. Oxidative stress and…”
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Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21Waf1/Cip1 mediated inhibition of Hh-Gli signaling by Mohapatra, Purusottam, Satapathy, Shakti Ranjan, Siddharth, Sumit, Das, Dipon, Nayak, Anmada, Kundu, Chanakya Nath

“…•Resveratrol+ curcumin synergistically caused apoptosis in MCF-10A-Tr cells.•Res facilitated Cmn uptake in MCF-10A-Tr cells.•Resveratrol+ curcumin induced…”
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Cytotoxic Effect of Microbial Biosurfactants Against Human Embryonic Kidney Cancerous Cell: HEK-293 and Their Possible Role in Apoptosis by Pradhan, Arun Kumar, Pradhan, Nilotpala, Mohapatra, Purusottam, Kundu, Chanakya Nath, Panda, Prasanna Kumar, Mishra, Barada Kanta

“…Two different microbial biosurfactants S9BS and CHBS were isolated from Lysinibacillus fusiformis S9 and Bacillus tequilensis CH. Cytotoxicity effect of these…”
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Resveratrol mediated cell death in cigarette smoke transformed breast epithelial cells is through induction of p21Waf1/Cip1 and inhibition of long patch base excision repair pathway by Mohapatra, Purusottam, Satapathy, Shakti Ranjan, Das, Dipon, Siddharth, Sumit, Choudhuri, Tathagata, Kundu, Chanakya Nath

“…Cigarette smoking is a key factor for the development and progression of different cancers including mammary tumor in women. Resveratrol (Res) is a promising…”
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