Search Results - "Kumps, Candy"

Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment by Lambertz, Irina, Kumps, Candy, Claeys, Shana, Lindner, Sven, Beckers, Anneleen, Janssens, Els, Carter, Daniel R, Cazes, Alex, Cheung, Belamy B, De Mariano, Marilena, De Bondt, An, De Brouwer, Sara, Delattre, Olivier, Gibbons, Jay, Janoueix-Lerosey, Isabelle, Laureys, Geneviève, Liang, Chris, Marchall, Glenn M, Porcu, Michael, Takita, Junko, Trujillo, David Camacho, Van Den Wyngaert, Ilse, Van Roy, Nadine, Van Goethem, Alan, Van Maerken, Tom, Zabrocki, Piotr, Cools, Jan, Schulte, Johannes H, Vialard, Jorge, Speleman, Frank, De Preter, Katleen

“…Activating ALK mutations are present in almost 10% of primary neuroblastomas and mark patients for treatment with small-molecule ALK inhibitors in clinical…”
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Targeted expression of mutated ALK induces neuroblastoma in transgenic mice by Heukamp, Lukas C, Thor, Theresa, Schramm, Alexander, De Preter, Katleen, Kumps, Candy, De Wilde, Bram, Odersky, Andrea, Peifer, Martin, Lindner, Sven, Spruessel, Annika, Pattyn, Filip, Mestdagh, Pieter, Menten, Björn, Kuhfittig-Kulle, Steffi, Künkele, Annette, König, Katharina, Meder, Lydia, Chatterjee, Sampurna, Ullrich, Roland T, Schulte, Stefanie, Vandesompele, Jo, Speleman, Frank, Büttner, Reinhard, Eggert, Angelika, Schulte, Johannes H

“…Activating anaplastic lymphoma kinase (ALK) mutations were recently detected in most familial and 10% of sporadic neuroblastomas. However, the role of mutated…”
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The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness by Mus, Liselot M., Lambertz, Irina, Claeys, Shana, Kumps, Candy, Van Loocke, Wouter, Van Neste, Christophe, Umapathy, Ganesh, Vaapil, Marica, Bartenhagen, Christoph, Laureys, Genevieve, De Wever, Olivier, Bexell, Daniel, Fischer, Matthias, Hallberg, Bengt, Schulte, Johannes, De Wilde, Bram, Durinck, Kaat, Denecker, Geertrui, De Preter, Katleen, Speleman, Frank

“…Neuroblastoma is an aggressive childhood cancer arising from sympatho-adrenergic neuronal progenitors. The low survival rates for high-risk disease point to an…”
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Pathophysiology of nocturnal lower urinary tract symptoms in older patients with urinary incontinence by Denys, Marie‐Astrid, Decalf, Veerle, Kumps, Candy, Petrovic, Mirko, Goessaert, An‐Sofie, Everaert, Karel

“…Objectives To explore the mismatch between functional bladder capacity and nocturnal urine production, and to study the pathophysiology of an increased…”
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Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome by Li, Dong, March, Michael E., Fortugno, Paola, Cox, Liza L., Matsuoka, Leticia S., Monetta, Rosanna, Seiler, Christoph, Pyle, Louise C., Bedoukian, Emma C., Sánchez-Soler, María José, Caluseriu, Oana, Grand, Katheryn, Tam, Allison, Aycinena, Alicia R. P., Camerota, Letizia, Guo, Yiran, Sleiman, Patrick, Callewaert, Bert, Kumps, Candy, Dheedene, Annelies, Buckley, Michael, Kirk, Edwin P., Turner, Anne, Kamien, Benjamin, Patel, Chirag, Wilson, Meredith, Roscioli, Tony, Christodoulou, John, Cox, Timothy C., Zackai, Elaine H., Brancati, Francesco, Hakonarson, Hakon, Bhoj, Elizabeth J.

“…Teebi hypertelorism syndrome (THS; OMIM 145420) is a rare craniofacial disorder characterized by hypertelorism, prominent forehead, short nose with broad or…”
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Focal DNA copy number changes in neuroblastoma target MYCN regulated genes by Kumps, Candy, Fieuw, Annelies, Mestdagh, Pieter, Menten, Björn, Lefever, Steve, Pattyn, Filip, De Brouwer, Sara, Sante, Tom, Schulte, Johannes Hubertus, Schramm, Alexander, Van Roy, Nadine, Van Maerken, Tom, Noguera, Rosa, Combaret, Valérie, Devalck, Christine, Westermann, Frank, Laureys, Geneviève, Eggert, Angelika, Vandesompele, Jo, De Preter, Katleen, Speleman, Frank

“…Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system cells. Recurrent genomic alterations include MYCN and ALK amplification as…”
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Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas by Fieuw, Annelies, Kumps, Candy, Schramm, Alexander, Pattyn, Filip, Menten, Björn, Antonacci, Francesca, Sudmant, Peter, Schulte, Johannes H., Van Roy, N, Vergult, Sarah, Buckley, Patrick G., De Paepe, A, Noguera, Rosa, Versteeg, Rogier, Stallings, Raymond, Eggert, Angelika, Vandesompele, Jo, De Preter, K, Speleman, Frank

“…Neuroblastoma is an aggressive embryonal tumor that accounts for ∼15% of childhood cancer deaths. Hitherto, despite the availability of comprehensive genomic…”
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Smoothing waves in array CGH tumor profiles by van de Wiel, Mark A., Brosens, Rebecca, Eilers, Paul H. C., Kumps, Candy, Meijer, Gerrit A., Menten, Björn, Sistermans, Erik, Speleman, Frank, Timmerman, Marieke E., Ylstra, Bauke

“…Motivation: Many high-resolution array comparative genomic hybridization tumor profiles contain a wave bias, which makes accurate detection of breakpoints in…”
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Prognostic and Therapeutic Implications of Circulating Androgen Receptor Gene Copy Number in Prostate Cancer Patients Using Droplet Digital Polymerase Chain Reaction by Buelens, Sarah, Claeys, Tom, Dhondt, Bert, Poelaert, Filip, Vynck, Matthijs, Yigit, Nurten, Thas, Olivier, Ost, Piet, Vandesompele, Jo, Lumen, Nicolaas, Kumps, Candy

“…Because resistance mechanisms in the androgen receptor (AR) pathway remain key drivers of progression, we assessed the AR gene copy number (CN) gain in a…”
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Effective Alu repeat based RT-Qpcr normalization in cancer cell perturbation experiments by Rihani, Ali, Van Maerken, Tom, Pattyn, Filip, Van Peer, Gert, Beckers, Anneleen, De Brouwer, Sara, Kumps, Candy, Mets, Evelien, Van der Meulen, Joni, Rondou, Pieter, Leonelli, Carina, Mestdagh, Pieter, Speleman, Frank, Vandesompele, Jo

“…Measuring messenger RNA (mRNA) levels using the reverse transcription quantitative polymerase chain reaction (RT-qPCR) is common practice in many laboratories…”
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Circadian Variation in Post Void Residual in Nursing Home Residents With Moderate Impairment in Activities of Daily Living by Decalf, Veerle, MSc, Huion, Anja, MSc, Denys, Marie-Astrid, MD, Kumps, Candy, MSc, PhD, Petrovic, Mirko, MD, PhD, Everaert, Karel, MD, PhD

“…Abstract Background Despite the conflicting evidence about postvoid residual (PVR) and its variation in time and corresponding voided volume (VV), studies with…”
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The independent oncological role for cytoreductive nephrectomy in metastatic renal cell carcinoma: Prognostic features in the era of targeted therapies by Claeys, Tom, M.D, Lumen, Nicolaas, M.D., Ph.D, Kumps, Candy, Ph.D, Praet, Marleen, M.D., Ph.D, De Meerleer, Gert, M.D., Ph.D, Rottey, Sylvie, M.D., Ph.D, Ost, Piet, M.D., Ph.D, Devisschere, Pieter, M.D., Ph.D, Villeirs, Geert, M.D., Ph.D, Fonteyne, Valerie, M.D., Ph.D, Decaestecker, Karel, M.D., Ph.D

“…Abstract Objectives To describe the effects of cytoreductive nephrectomy (CN) on the natural course of metastatic renal cell carcinoma (mRCC). CN appears to…”
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Clean Intermittent Self-Catheterization as a Treatment Modality for Urinary Retention: Perceptions of Urologists by Weynants, Laurens, Hervé, François, Decalf, Veerle, Kumps, Candy, Pieters, Ronny, Troyer, Bart de, Everaert, Karel

“…Clean intermittent self-catheterization (CISC) is now considered the gold standard for the management of urinary retention. In the literature, several articles…”
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Multiplex Amplicon Quantification (MAQ), a fast and efficient method for the simultaneous detection of copy number alterations in neuroblastoma by Kumps, Candy, Van Roy, Nadine, Heyrman, Lien, Goossens, Dirk, Del-Favero, Jurgen, Noguera, Rosa, Vandesompele, Jo, Speleman, Frank, De Preter, Katleen

“…Cancer genomes display characteristic patterns of chromosomal imbalances, often with diagnostic and prognostic relevance. Therefore assays for genome-wide copy…”
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Identification of tumoral glial precursor cells in neuroblastoma by Acosta, Sandra, Mayol, Gemma, Rodríguez, Eva, Lavarino, Cinzia, de Preter, Katleen, Kumps, Candy, Garcia, Idoia, de Torres, Carmen, Mora, Jaume

“…Highlights ► We describe a neuroblastic subpopulation coexpressing neuronal and glial markers. ► The GD2+ /S100A6+ subpopulation is more common in low risk…”
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The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors by Castelletti, Deborah, Fiaschetti, Giulio, Di Dato, Valeria, Ziegler, Urs, Kumps, Candy, De Preter, Katleen, Zollo, Massimo, Speleman, Frank, Shalaby, Tarek, De Martino, Daniela, Berg, Thorsten, Eggert, Angelika, Arcaro, Alexandre, Grotzer, Michael A

“…The quassinoid analogue NBT-272 has been reported to inhibit MYC, thus warranting a further effort 7to better understand its preclinical properties in models…”
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Methylation signatures in clinically variable syndromic disorders: a familial DNMT3A variant in two adults with Tatton-Brown-Rahman syndrome by Kumps, Candy, D'haenens, Erika, Kerkhof, Jennifer, McConkey, Haley, Alders, Marielle, Sadikovic, Bekim, Vanakker, Olivier M

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Phenotypic spectrum of the RBM10‐mediated intellectual disability and congenital malformation syndrome beyond classic TARP syndrome features by Kumps, Candy, D'haenens, Erika, Vergult, Sarah, Leus, Jasmine, Coster, Rudy, Jansen, Anna, Devriendt, Koen, Oostra, Anna, Vanakker, Olivier M.

“…Pathogenic variants in the RBM10 gene cause a rare X‐linked disorder described as TARP (Talipes equinovarus, Atrial septal defect, Robin sequence, and…”
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Smart diapers for nursing home residents with dementia: a pilot study by Huion, Anja, Decalf, Veerle, Kumps, Candy, De Witte, Nico, Everaert, Karel

“…Objectives: The objective of the study is to evaluate the use of an experimental smart diaper as an indicator of saturation for diaper change in persons with…”
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MYT1L-associated neurodevelopmental disorder: description of 40 new cases and literature review of clinical and molecular aspects by Coursimault, Juliette, Guerrot, Anne-Marie, Morrow, Michelle M., Schramm, Catherine, Zamora, Francisca Millan, Shanmugham, Anita, Liu, Shuxi, Zou, Fanggeng, Bilan, Frédéric, Le Guyader, Gwenaël, Bruel, Ange-Line, Denommé-Pichon, Anne-Sophie, Faivre, Laurence, Tran Mau-Them, Frédéric, Tessarech, Marine, Colin, Estelle, El Chehadeh, Salima, Gérard, Bénédicte, Schaefer, Elise, Cogne, Benjamin, Isidor, Bertrand, Nizon, Mathilde, Doummar, Diane, Valence, Stéphanie, Héron, Delphine, Keren, Boris, Mignot, Cyril, Coutton, Charles, Devillard, Françoise, Alaix, Anne-Sophie, Amiel, Jeanne, Colleaux, Laurence, Munnich, Arnold, Poirier, Karine, Rio, Marlène, Rondeau, Sophie, Barcia, Giulia, Callewaert, Bert, Dheedene, Annelies, Kumps, Candy, Vergult, Sarah, Menten, Björn, Chung, Wendy K., Hernan, Rebecca, Larson, Austin, Nori, Kelly, Stewart, Sarah, Wheless, James, Kresge, Christina, Pletcher, Beth A., Caumes, Roseline, Smol, Thomas, Sigaudy, Sabine, Coubes, Christine, Helm, Margaret, Smith, Rosemarie, Morrison, Jennifer, Wheeler, Patricia G., Kritzer, Amy, Jouret, Guillaume, Afenjar, Alexandra, Deleuze, Jean-François, Olaso, Robert, Boland, Anne, Poitou, Christine, Frebourg, Thierry, Houdayer, Claude, Saugier-Veber, Pascale, Nicolas, Gaël, Lecoquierre, François

“…Pathogenic variants of the myelin transcription factor-1 like ( MYT1L ) gene include heterozygous missense, truncating variants and 2p25.3 microdeletions and…”
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