Search Results - "Kummetha, Indrasena Reddy"

Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers by Yau, Edwin H, Kummetha, Indrasena Reddy, Lichinchi, Gianluigi, Tang, Rachel, Zhang, Yunlin, Rana, Tariq M

“…Targeting mutant KRAS signaling pathways continues to attract attention as a therapeutic strategy for KRAS-driven tumors. In this study, we exploited the power…”
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An efficient synthesis and biological screening of benzofuran and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB inhibition by Reddy, Kummetha Indrasena, Srihari, Konduri, Renuka, Janupally, Sree, Komanduri Shruthi, Chuppala, Aruna, Jeankumar, Variam Ullas, Sridevi, Jonnalagadda Padma, Babu, Kondra Sudhakar, Yogeeswari, Perumal, Sriram, Dharmarajan

“…[Display omitted] A series of twenty eight molecules of ethyl 5-(piperazin-1-yl)benzofuran-2-carboxylate and 3-(piperazin-1-yl)benzo[d]isothiazole were…”
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HIV-1 Escape from Small-Molecule Antagonism of Vif by Sharkey, Mark, Sharova, Natalia, Mohammed, Idrees, Huff, Sarah E, Kummetha, Indrasena Reddy, Singh, Gatikrushna, Rana, Tariq M, Stevenson, Mario

“…The HIV-1 accessory protein Vif, which counteracts the antiviral action of the DNA-editing cytidine deaminase APOBEC3G (A3G), is an attractive and yet…”
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Discovery and Mechanism of SARS-CoV‑2 Main Protease Inhibitors by Huff, Sarah, Kummetha, Indrasena Reddy, Tiwari, Shashi Kant, Huante, Matthew B, Clark, Alex E, Wang, Shaobo, Bray, William, Smith, Davey, Carlin, Aaron F, Endsley, Mark, Rana, Tariq M

“…The emergence of a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents an urgent public health crisis. Without available…”
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Rational Design and Optimization of m6A‑RNA Demethylase FTO Inhibitors as Anticancer Agents by Huff, Sarah, Kummetha, Indrasena Reddy, Zhang, Lingzhi, Wang, Lingling, Bray, William, Yin, Jiekai, Kelley, Vanessa, Wang, Yinsheng, Rana, Tariq M.

“…Aberrant regulation of N 6-methyladenosine (m6A) RNA modification has been implicated in the progression of multiple diseases, including cancer. Previously, we…”
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Rational Design and Optimization of m 6 A-RNA Demethylase FTO Inhibitors as Anticancer Agents by Huff, Sarah, Kummetha, Indrasena Reddy, Zhang, Lingzhi, Wang, Lingling, Bray, William, Yin, Jiekai, Kelley, Vanessa, Wang, Yinsheng, Rana, Tariq M.

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1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV‑1 Vif Antagonists by Mohammed, Idrees, Kummetha, Indrasena Reddy, Singh, Gatikrushna, Sharova, Natalia, Lichinchi, Gianluigi, Dang, Jason, Stevenson, Mario, Rana, Tariq M

“…RN-18 based viral infectivity factor (Vif), Vif antagonists reduce viral infectivity by rescuing APOBEC3G (A3G) expression and enhancing A3G-dependent Vif…”
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Design, synthesis, biological evaluation of substituted benzofurans as DNA gyraseB inhibitors of Mycobacterium tuberculosis by Renuka, Janupally, Reddy, Kummetha Indrasena, Srihari, Konduri, Jeankumar, Variam Ullas, Shravan, Morla, Sridevi, Jonnalagadda Padma, Yogeeswari, Perumal, Babu, Kondra Sudhakar, Sriram, Dharmarajan

“…DNA gyrase of Mycobacterium tuberculosis (MTB) is a type II topoisomerase and is a well-established and validated target for the development of novel…”
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Small-molecule PTPN2 Inhibitors Sensitize Resistant Melanoma to Anti-PD-1 Immunotherapy by Zhu, Zhouting, Tang, Rachel, Huff, Sarah, Kummetha, Indrasena Reddy, Wang, Lingling, Li, Na, Rana, Tariq M

“…Although immune checkpoint inhibitors targeting T-cell immunoregulatory proteins have revolutionized cancer treatment, they are effective only in a limited…”
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