Search Results - "Kummer, Sandra"
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WRNIP1 Protects Reversed DNA Replication Forks from SLX4-Dependent Nucleolytic Cleavage
Published in iScience (22-11-2019)“…During DNA replication stress, stalled replication forks need to be stabilized to prevent fork collapse and genome instability. The AAA + ATPase WRNIP1 (Werner…”
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The conscientiousness-health link in depression: Results from a path analysis
Published in Journal of affective disorders (01-12-2021)“…•Path analyses of conscientiousness, health risk behaviors and indicators of health.•Large clinical sample with depressive symptomatology.•Less conscientious…”
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The protein landscape of chronic lymphocytic leukemia
Published in Blood (16-12-2021)“…Many functional consequences of mutations on tumor phenotypes in chronic lymphocytic leukemia (CLL) are unknown. This may be in part due to a scarcity of…”
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Human DNA polymerase delta requires an iron-sulfur cluster for high-fidelity DNA synthesis
Published in Life science alliance (01-08-2019)“…Replication of eukaryotic genomes relies on the family B DNA polymerases Pol α, Pol δ, and Pol ε. All of these enzymes coordinate an iron-sulfur (FeS) cluster,…”
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Lymphoma and Leukemia Cell Vulnerabilities and Resistance Identified by Compound Library Screens
Published in Methods in molecular biology (Clifton, N.J.) (2025)“…Response to anticancer agents is often restricted to subsets of patients. Recognition of factors underlying this heterogeneity and identification of biomarkers…”
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The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation
Published in Life science alliance (01-03-2020)“…The iron-sulfur (FeS) cluster helicase DDX11 is associated with a human disorder termed Warsaw Breakage Syndrome. Interestingly, one disease-associated…”
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WRNIP1 Protects Reversed DNA Replication Forks from SLX4-Dependent Nucleolytic Cleavage
Published in iScience (01-11-2019)Get full text
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The iron–sulphur cluster in human DNA2 is required for all biochemical activities of DNA2
Published in Communications biology (23-06-2020)“…The nuclease/helicase DNA2 plays important roles in DNA replication, repair and processing of stalled replication forks. DNA2 contains an iron-sulphur (FeS)…”
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Proteomic identification of proliferation and progression markers in human polycythemia vera stem and progenitor cells
Published in Blood advances (14-06-2022)“…Polycythemia vera (PV) is a stem cell disorder characterized by hyperproliferation of the myeloid lineages and the presence of an activating JAK2 mutation. To…”
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