Search Results - "Kumkum Saxena"

Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit by Byrn, Randal A, Jones, Steven M, Bennett, Hamilton B, Bral, Chris, Clark, Michael P, Jacobs, Marc D, Kwong, Ann D, Ledeboer, Mark W, Leeman, Joshua R, McNeil, Colleen F, Murcko, Mark A, Nezami, Azin, Perola, Emanuele, Rijnbrand, Rene, Saxena, Kumkum, Tsai, Alice W, Zhou, Yi, Charifson, Paul S

“…VX-787 is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. Viral genetics…”
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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases by Farmer, Luc J, Ledeboer, Mark W, Hoock, Thomas, Arnost, Michael J, Bethiel, Randy S, Bennani, Youssef L, Black, James J, Brummel, Christopher L, Chakilam, Ananthsrinivas, Dorsch, Warren A, Fan, Bin, Cochran, John E, Halas, Summer, Harrington, Edmund M, Hogan, James K, Howe, David, Huang, Hui, Jacobs, Dylan H, Laitinen, Leena M, Liao, Shengkai, Mahajan, Sudipta, Marone, Valerie, Martinez-Botella, Gabriel, McCarthy, Pamela, Messersmith, David, Namchuk, Mark, Oh, Luke, Penney, Marina S, Pierce, Albert C, Raybuck, Scott A, Rugg, Arthur, Salituro, Francesco G, Saxena, Kumkum, Shannon, Dean, Shlyakter, Dina, Swenson, Lora, Tian, Shi-Kai, Town, Christopher, Wang, Jian, Wang, Tiansheng, Wannamaker, M. Woods, Winquist, Raymond J, Zuccola, Harmon J

“…While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting…”
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The Structural Basis for Autoinhibition of FLT3 by the Juxtamembrane Domain by Griffith, James, Black, James, Faerman, Carlos, Swenson, Lora, Wynn, Michael, Lu, Fan, Lippke, Judith, Saxena, Kumkum

“…FLT3 is a type III receptor tyrosine kinase that is thought to play a key role in hematopoiesis. Certain classes of FLT3 mutations cause constitutively…”
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The WD repeat: a common architecture for diverse functions by Smith, Temple F, Gaitatzes, Chrysanthe, Saxena, Kumkum, Neer, Eva J

“…Our knowledge of the large family of proteins that contain the WD repeat continues to accumulate. The WD-repeat proteins are found in all eukaryotes and are…”
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Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002 by Jacobs, Marc D., Black, James, Futer, Olga, Swenson, Lora, Hare, Brian, Fleming, Mark, Saxena, Kumkum

“…Pim-1 is an oncogene-encoded serine/threonine kinase primarily expressed in hematopoietic and germ cell lines. Pim-1 kinase was originally identified in…”
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Structure and properties of totally synthetic galacto- and gluco-cerebrosides by Saxena, K, Duclos, R.I, Zimmermann, P, Schmidt, R.R, Shipley, G.G

“…The structural and thermal properties of aqueous dispersions of the totally synthetic cerebrosides, D-erythro-N-palmitoyl galactosyl- and…”
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ProtonMail: Advance Encryption and Security by Saxena, Professor Kumkum, Rajdev, Dev, Bhatia, Divesh, Bahl, Manav

“…The objective of the paper was to reinforce security and to make privacy a priority in mailing services. There has been an excellent effort over a few decades…”
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Bilayer Properties of Totally Synthetic C16:0-Lactosyl-Ceramide by Saxena, Kumkum, Zimmermann, Peter, Schmidt, Richard R., Shipley, G. Graham

“…Differential scanning calorimetry (DSC) and x-ray diffraction have been used to study the structural and thermal properties of totally synthetic d-erythro-…”
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Nonstructural protein 5A (NS5A) and human replication protein A increase the processivity of hepatitis C virus NS5B polymerase activity in vitro by Mani, Nagraj, Yuzhakov, Alexander, Yuzhakov, Olga, Coll, Joyce T, Black, Jim, Saxena, Kumkum, Fulghum, John R, Lippke, Judith A, Rao, B Govinda, Rijnbrand, Rene, Kwong, Ann D

“…The precise role(s) and topological organization of different factors in the hepatitis C virus (HCV) RNA replication complex are not well understood. In order…”
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Cross-Language Assessment of Mathematical Capability of ChatGPT by Sathe, Gargi, Shamraj, Aneesh, Surve, Aditya, Patil, Nahush, Saxena, Kumkum

“…This paper presents an evaluation of the mathematical capability of ChatGPT across diverse languages like Hindi, Gujarati, and Marathi. ChatGPT, based on…”
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Crystal Structures of the XLP Protein SAP Reveal a Class of SH2 Domains with Extended, Phosphotyrosine-Independent Sequence Recognition by Poy, Florence, Yaffe, Michael B, Sayos, Joan, Saxena, Kumkum, Morra, Massimo, Sumegi, Janos, Cantley, Lewis C, Terhorst, Cox, Eck, Michael J

“…SAP, the product of the gene mutated in X-linked lymphoproliferative syndrome (XLP), consists of a single SH2 domain that has been shown to bind the…”
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Using Ensemble of Multiple Fine-Tuned EfficientNet Models for Skin Cancer Classification by Joshi, Karan P., Davaria, Sneh, Saxena, Kumkum

“…Skin cancer is a prevalent form of cancer, and its early and accurate identification is critical for effective treatment. In this research paper, using an…”
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Leveraging CNNs and Ensemble Learning for Automated Disaster Image Classification by Rathod, Archit, Pariawala, Veer, Surana, Mokshit, Saxena, Kumkum

“…Natural disasters act as a serious threat globally, requiring effective and efficient disaster management and recovery. This paper focuses on classifying…”
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The Quest for Fairness: A Comparative Study of Accuracy in AI Hiring Systems by D'souza, Jason, Kadam, Vedant, Shinde, Pranali, Saxena, Kumkum

“…Artificial Intelligence and Machine Learning based models are increasingly being used in developing models for automating recruitment systems in various…”
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Comparison of Machine Learning Algorithms for Obesity Prediction by Fernandes, Aaron, Dahikar, Sneha, Chopra, Karan, Saxena, Kumkum

“…Obesity has plagued the world in recent years and is a serious health issue in the modern times. There are various parameters that have led to this epidemic…”
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Unveling Chess Algorithms Using Reinforcement Learning and Traditional Chess Approaches in AI by Khokhani, Ishika, Nathani, Juhi, Dhawane, Prem, Madhani, Smit, Saxena, Kumkum

“…In the history of Artificial Intelligence, chess has been the subject of the many researches. Chess bots are now capable of beating grandmasters using…”
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Generation and grading of arduous MCQs using NLP and OMR detection using OpenCV by Maniar, Sarjak, Parmani, Jai, Bodke, Mihika, Saxena, Kumkum

“…During the 21st century pandemic, it has become difficult for students and teachers to engage physically in the aftermath of the epidemic, the process of…”
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Sites Important for PLCβ2 Activation by the G Protein βγ Subunit Map to the Sides of the β Propeller Structure by Panchenko, Mikhail P., Saxena, Kumkum, Li, Ying, Charnecki, Sara, Sternweis, Pamela M., Smith, Temple F., Gilman, Alfred G., Kozasa, Tohru, Neer, Eva J.

“…The βγ subunits of the heterotrimeric GTP-binding proteins (G proteins) that couple heptahelical, plasma membrane-bound receptors to intracellular effector…”
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Trust and behavior based system to prevent collision in IoT enabled VANET by Talreja, Rahul, Sathish, SriPradha, Nenwani, Kamlesh, Saxena, Kumkum

“…The paper proposes a method to make roads a safer place for driving by taking advantage of Internet of Things (IoT) enabled vehicles. The proposed method is…”
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A novel approach based on intersection and direction to optimize hard handover in mobile WiMAX by Talreja, Rahul, Jethani, Vimla, Marathe, Nilesh, Saxena, Kumkum

“…The IEEE 802.16e [Mobile Worldwide Interoperability for Microwave Access(MWiMAX)] standard supports the mobility of Subscriber Station (SS), thus making them…”
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