Factors associated with culture proven neonatal sepsis in the Ho municipality 2016

Neonatal Sepsis (NNS) is a public health problem which causes death or disability unless appropriate antibiotic treatment is given promptly. Globally, sepsis is an important cause of morbidity and mortality in neonates despite recent progress in health care delivery. We assessed the factors associat...

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Bibliographic Details
Published in:	The Pan African medical journal Vol. 36; no. 281; p. 281
Main Authors:	Aku, Fortress Yayra, Akweongo, Patricia, Nyarko, Kofi Mensah, Mensah, Lord Graceful, Amegan-Aho, Kokou, Kumi, Lawrence, Afari, Edwin Andrew, Ameme, Donne Kofi, Kenu, Ernest
Format:	Journal Article
Language:	English
Published:	Uganda The African Field Epidemiology Network 2020 The Pan African Medical Journal
Subjects:	Adult antenatal clinic Anti-Bacterial Agents - administration & dosage Cross-Sectional Studies culture Female Ghana Gravidity ho municipality Humans Infant, Newborn Intensive Care Units, Neonatal Male neonatal sepsis Neonatal Sepsis - diagnosis Neonatal Sepsis - drug therapy Neonatal Sepsis - microbiology parity Pregnancy Prenatal Care - statistics & numerical data Young Adult Ghana Ho municipality antenatal clinic culture parity Neonatal sepsis
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Summary:	Neonatal Sepsis (NNS) is a public health problem which causes death or disability unless appropriate antibiotic treatment is given promptly. Globally, sepsis is an important cause of morbidity and mortality in neonates despite recent progress in health care delivery. We assessed the factors associated with culture proven sepsis among neonates in the Ho Municipality, Ghana. a cross-sectional study was conducted in two public hospitals in the Ho Municipality between January and May, 2016. All neonates who were clinically suspected with sepsis in the Neonatal Intensive Care Unit (NICU) and their mothers were recruited. A 2ml blood sample was taken aseptically and dispensed into a mixture of thioglycollate and tryptone soy broth in a 1: 10 dilution and microbiological procedures performed. Case notes of both neonates and their mothers were reviewed and interviews conducted to collect both clinical and socio-demographic data. We determined the factors associated with culture proven neonatal sepsis using logistic regression model and statistical significance was determined at 95% confidence intervals. out of 150 neonates, 26 (17%) had laboratory confirmed sepsis. The most common pathogen isolated was Staphylococcus epidermidis 14, (54%). Neonates whose mothers were primigravida (OR=2.74; 95% CI: 1.12-6.68), and those who attended antenatal clinics (ANC) fewer than three schedules (OR=2.90; 95% CI: 1.06-7.96) had higher odds of developing culture proven sepsis. neonates who were the first babies of their mothers were more likely to develop laboratory confirmed sepsis. Also, neonates of mothers who attended ANC less than 3 times were more likely to develop laboratory confirmed sepsis. High index of suspicion is required to diagnose neonatal sepsis among neonates of primigravida mothers and mothers who attend fewer than three ANC schedules.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1937-8688 1937-8688
DOI:	10.11604/pamj.2020.36.281.20408