Perivascular CSF flow in the rat cerebellum

Perivascular CSF flow in the rat cerebellum

Cerebrospinal fluid (CSF) flow from the subarachnoid space into the cerebellum was studied in rats using Horseradish peroxidase (HRP) injected into the cisterna magna. Animals were sacrificed after 0, 10 or 30 min Transpial diffusion of HRP did not extend beyond the Purkinje cell layer. At all time...

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Bibliographic Details
Published in:Journal of clinical neuroscience Vol. 6; no. 2; pp. 143 - 146
Main Authors: Kumari, R.R, Dhaliwal, J.S, Stoodley, M.A, Jones, N.R
Format: Journal Article
Language:English
Published: Amsterdam Elsevier Ltd 01-03-1999
Elsevier
Subjects:
Biological and medical sciences
cerebellum
Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges
CSF flow
Fundamental and applied biological sciences. Psychology
HRP
perivascular spaces
rat
Tropical medicine
Vertebrates: nervous system and sense organs
perivascular spaces
CSF flow
rat
cerebellum
HRP
Cerebellum
Fluid dynamics
Rat
Rodentia
Central nervous system
Flux
Exploration
Cerebrospinal fluid
Vertebrata
Mammalia
Subarachnoidal space
Adult animal
Kinetics
Brain (vertebrata)
Coloration
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Summary:Cerebrospinal fluid (CSF) flow from the subarachnoid space into the cerebellum was studied in rats using Horseradish peroxidase (HRP) injected into the cisterna magna. Animals were sacrificed after 0, 10 or 30 min Transpial diffusion of HRP did not extend beyond the Purkinje cell layer. At all time intervals, perivascular spaces labelled with HRP were observed in cerebellar grey and white matter. In the cerebellar granular layer and white matter, HRP was usually present only in perivascular spaces and the surrounding extracellular space. There was no evidence of a preferential flow towards the fourth ventricle. These results suggest that there is a perivascular pathway for rapid flow of CSF from the subarachnoid space into the perivascular spaces and then into the cerebellar extracellular space. The Purkinje cell layer appears to act as a barrier to diffusion from the pial surface.
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ISSN:0967-5868
1532-2653
DOI:10.1016/S0967-5868(99)90080-2