Thyroid Hormone Levels in Term Neonates with Early-onset Sepsis and Healthy Controls in Northwest India

Background: Neonatal sepsis is responsible for about 30%–50% of the total neonatal deaths in developing countries. Thyroid hormone changes are highly common in hospitalized patients or with critical illnesses. The aim of the study is to compare thyroid hormone profile in term neonates with early-ons...

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Bibliographic Details
Published in:	Chrismed journal of health and research Vol. 10; no. 3; pp. 260 - 262
Main Authors:	Manav, Gargi, Meena, Kailash, Garg, Vijendra Kumar, Meena, Shivlal, Kumari, Pawan
Format:	Journal Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 01-07-2023
Subjects:	euthyroid sick syndrome neonatal sepsis nonthyroidal illness syndrome thyroid hormone profile
Online Access:	Get full text
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Summary:	Background: Neonatal sepsis is responsible for about 30%–50% of the total neonatal deaths in developing countries. Thyroid hormone changes are highly common in hospitalized patients or with critical illnesses. The aim of the study is to compare thyroid hormone profile in term neonates with early-onset sepsis (EOS) and healthy controls and their association with outcome of sepsis. Materials and Methods: A total of 150 neonates, 75 cases with EOS and 75 healthy controls, were included in this study. EOS was defined according to the European Medical Agency Sepsis Criteria of neonatal sepsis. Results: The mean free triiodothyronine and mean thyroid-stimulating hormone level in neonates with EOS were significantly lower than in control group. Conclusion: Neonatal sepsis causes significant alteration in thyroid hormone profile in term neonates with EOS.
ISSN:	2348-3334 2348-506X
DOI:	10.4103/cjhr.cjhr_55_23