Search Results - "Kumaran, R. Ileng"

genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence by Kumaran, R. Ileng, Spector, David L

“…The peripheral nuclear lamina, which is largely but not entirely associated with inactive chromatin, is considered to be an important determinant of nuclear…”
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Receptor-mediated delivery of engineered nucleases for genome modification by Chen, Zhong, Jaafar, Lahcen, Agyekum, Davies G, Xiao, Haiyan, Wade, Marlene F, Kumaran, R Ileng, Spector, David L, Bao, Gang, Porteus, Matthew H, Dynan, William S, Meiler, Steffen E

“…Engineered nucleases, which incise the genome at predetermined sites, have a number of laboratory and clinical applications. There is, however, a need for…”
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Lamin A/C haploinsufficiency modulates the differentiation potential of mouse embryonic stem cells by Sehgal, Poonam, Chaturvedi, Pankaj, Kumaran, R Ileng, Kumar, Satish, Parnaik, Veena K

“…Lamins are structural proteins that are the major determinants of nuclear architecture and play important roles in various nuclear functions including gene…”
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Chromatin Dynamics and Gene Positioning by Kumaran, R. Ileng, Thakar, Rajika, Spector, David L.

“…The mammalian cell nucleus provides a landscape where genes are regulated through their organization and association with freely diffusing proteins and nuclear…”
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Lamin A/C Speckles Mediate Spatial Organization of Splicing Factor Compartments and RNA Polymerase II Transcription by Kumaran, R. Ileng, Muralikrishna, Bhattiprolu, Parnaik, Veena K.

“…The A-type lamins have been observed to colocalize with RNA splicing factors in speckles within the nucleus, in addition to their typical distribution at the…”
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Abstract 4087: ALDH1A1 inhibitor induces cell cycle arrest and reduces cell proliferation of cisplatin-resistant ovarian cancer cells by Ramachandran, Ilangovan, Ramadoss, Sivakumar, Karuppaiyah, Selvendiran, Nathan, Lauren, Kumaran, R. Ileng, Chaudhuri, Gautam

“…Introduction: Ovarian cancer is one of the most common malignancies among women that causes severe mortality in USA and globally. Despite advances in cancer…”
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563. Analysis of DNA Repair Pathway Choice Upon Induction of Double-Strand Breaks by Engineered Nuclease by Kumaran, R. Ileng, Li, Jingjing, Dynan, William S., Porteus, Matthew H., Spector, David L.

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Inhibition of ALDH1A1 Activity in Cisplatin-Resistant Ovarian Cancer Cells Alters Their Cancer Stemness, Cell Cycle Profile and Mitochondrial Respiration Rate by Ramachandran, Ilangovan, Ramadoss, Sivakumar, Sen, Suvajit, Karuppaiyah, Selvendiran, Kumaran, R Ileng, Chaudhuri, Gautam

“…Introduction: Ovarian cancer is one of the leading cause of morbidity and death among women, with a five-year relative survival rate of only 30% in patients…”
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MON-513 Suppressing the Growth of Human Medullary Thyroid Cancer Cells Using FDA-Approved Drug by Ramachandran, Ilangovan, Ramadoss, Sivakumar, Nathan, Lauren, Kumaran, R Ileng, Chaudhuri, Gautam

“…Medullary thyroid carcinoma (MTC) is a solid tumor of the parafollicular cells in the thyroid gland. MTC has worse prognosis, when compared with other…”
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A Biological Delivery Platform for Zinc Finger Nucleases Using Transferrin-Mediated Endocytosis by Meiler, Steffen E., Dynan, William S., Porteus, Matthew, Spector, David L., Bao, Gang, Chen, Zhong, Pandey, Jay, Goyal, Deepika, Kumaran, R. Ileng, Wade, Marlene, Agyekum, Davies

“…Abstract 1071 Zinc finger nucleases (ZFNs) are custom-designed DNA binding proteins that produce DNA double-strand breaks (DSBs) at predetermined genomic…”
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