Search Results - "Kumar. S, Udhaya"

Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach by Udhaya Kumar, S, Thirumal Kumar, D, Bithia, R, Sankar, Srivarshini, Magesh, R, Sidenna, Mariem, George Priya Doss, C, Zayed, Hatem

“…Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease. This study focused on…”
Get full text

PSO-based feature selection and neighborhood rough set-based classification for BCI multiclass motor imagery task by Udhaya Kumar, S., Hannah Inbarani, H.

“…In recent years, most of the researchers are developing brain–computer interface (BCI) applications for the physically disabled to be able to interconnect with…”
Get full text

Identification of potential inhibitors, conformational dynamics, and mechanistic insights into mutant Kirsten rat sarcoma virus (G13D) driven cancers by Tayubi, Iftikhar A., Kumar S., Udhaya, Doss C., George Priya

“…The mutations at the hotspot region of K‐Ras result in the progression of cancer types. Our study aimed to explore the small molecule inhibitors against the…”
Get full text

Computational investigation to identify potent inhibitors of the GTPase-Kirsten RAt sarcoma virus (K-Ras) mutants G12C and G12D by Kumar, S. Udhaya, Priya Doss, C. George

“…K-Ras mutations are frequent in various cancer types, and according to recent research, K-Ras possesses four-drug targeting sites. This increased our interest…”
Get full text

Molecular dynamics simulations corroborate recombinant expression studies carried out on three αIIb β‐propeller mutations reported in Indian Glanzmann thrombasthenia patients by Chandrasekaran, Finola Priyadharshini, Vishal, Adarsh, Arora, Udita, Kumar S., Udhaya, George C., Priya Doss, Nelson, Everette Jacob Remington

“…Mutations in the αIIb β‐propeller domain have long been known to disrupt heterodimerization and intracellular trafficking of αIIbβ3 complexes leading to…”
Get full text

Unraveling the versatility of CCD4: Metabolic engineering, transcriptomic and computational approaches by Varghese, Ressin, S., Udhaya Kumar, C., George Priya Doss, Ramamoorthy, Siva

“…•Structure and multifunctionality of CCD4.•Various metabolic, computational transcriptomic approaches adopted to reveal the functional diversity of…”
Get full text

Effects of the pathological E200K mutation on human prion protein: A computational screening and molecular dynamics approach by Gharemirshamloo, Fatemeh Rahimi, Majumder, Ranabir, Kumar S., Udhaya, Doss C., George Priya, Bamdad, Kourosh, Frootan, Fateme, Un, Cemal

“…The human prion protein gene (PRNP) is mapped to the short arm of chromosome 20 (20pter‐12). Prion disease is associated with mutations in the prion…”
Get full text

Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach by S, Udhaya Kumar, Sankar, Srivarshini, Younes, Salma, D, Thirumal Kumar, Ahmad, Muneera Naseer, Okashah, Sarah Samer, Kamaraj, Balu, Al-Subaie, Abeer Mohammed, C, George Priya Doss, Zayed, Hatem

“…Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and…”
Get full text

Comparison of potential inhibitors and targeting fat mass and obesity‐associated protein causing diabesity through docking and molecular dynamics strategies by Kumar, S Udhaya, Rajan, Bithia, Kumar, D Thirumal, Cathryn, R Hephzibah, Das, Samprita, Zayed, Hatem, Emmanuel Jebaraj Walter, Charles, Ramanathan, Gnanasambandan, Priya Doss. C, George

“…Genome‐wide association studies (GWAS) have identified an association between polymorphisms in the FTO gene and obesity. The FTO: rs9939609, an intronic…”
Get full text

Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer by Kumar, S Udhaya, Kumar, D Thirumal, Siva, R, Doss, C George Priya, Zayed, Hatem

“…Ovarian cancer (OC) is the seventh most commonly detected cancer among women. This study aimed to map the hub and core genes and potential pathways that might…”
Get full text

Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients - A Bioinformatics Approach by Udhaya Kumar, S, Thirumal Kumar, D, Siva, R, George Priya Doss, C, Younes, Salma, Younes, Nadin, Sidenna, Mariem, Zayed, Hatem

“…Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder that is clinically complex and has increased production of autoantibodies. Via…”
Get full text

The Rise and Impact of COVID-19 in India by Kumar, S. Udhaya, Kumar, D. Thirumal, Christopher, B. Prabhu, Doss, C. George Priya

“…The coronavirus disease (COVID-19) pandemic, which originated in the city of Wuhan, China, has quickly spread to various countries, with many cases having been…”
Get full text

Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity by S., Udhaya Kumar, Rajan, Bithia, D., Thirumal Kumar, V., Anu Preethi, Abunada, Taghreed, Younes, Salma, Okashah, Sarah, Ethiraj, Selvarajan, C., George Priya Doss, Zayed, Hatem

“…(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious health problem that is associated with an increased risk of…”
Get full text

The targeted next-generation sequence revealed SMAD4, AKT1, and TP53 mutations from circulating cell-free DNA of breast cancer and its effect on protein structure - A computational approach by Balasundaram, Ambritha, Kumar. S, Udhaya, D, Thirumal Kumar, Anil Dedge, Aditi, R, Gnanasambandan, K, Satish Srinivas, R, Siva, C, George Priya Doss

“…Breast cancer biomarkers that detect marginally advanced stages are still challenging. The detection of specific abnormalities, targeted therapy selection,…”
Get full text

SARS-CoV-2 vaccine breakthrough infections (VBI) by Omicron variant (B.1.1.529) and consequences in structural and functional impact by Abduljaleel, Zainularifeen, Melebari, Sami, Athar, Mohammad, Dehlawi, Saied, Udhaya Kumar, S., Aziz, Syed A., Dannoun, Anas Ibrahim, Malik, Shaheer M., Thasleem, Jasheela, George Priya Doss, C.

“…This study investigated the efficacy of existing vaccines against hospitalization and infection due to the Omicron variant of COVID-19, particularly for those…”
Get full text

Unraveling the intricate physiological processes dysregulated in CHD-affected and Dan-Lou tablet-treated individuals by Datta, Ankur, George, Neethu, Koppolu, Tejaswini, Kumar. S, Udhaya, Bithia, R., Zayed, Hatem, Doss. C, George Priya

“…Coronary heart disease (CHD), a multifactorial cardiovascular condition, arises from the accumulation of atherosclerotic plaque in the coronary arteries,…”
Get full text

A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation by Balasundaram, Ambritha, Ramireddy, Sriroopreddy, S., Udhaya Kumar, D., Thirumal Kumar, Tayubi, Iftikhar Aslam, Zayed, Hatem, C., George Priya Doss

“…Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by insufficient aspartylglucosaminidase (AGA) activity leading to chronic…”
Get full text

Residue interaction networks of K-Ras protein with water molecules identifies the potential role of switch II and P-loop by Kumar, S. Udhaya, Priya Doss, C. George

“…The mutant K-Ras with aberrant signaling is the primary cause of several cancers. The proposed study investigated the influence of water molecules in K-Ras…”
Get full text

Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III by Kumar, S. Udhaya, Sankar, Srivarshini, Kumar, D. Thirumal, Younes, Salma, Younes, Nadin, Siva, R., Doss, C. George Priya, Zayed, Hatem

“…Epimerase-deficiency galactosemia (EDG) is caused by mutations in the UDP-galactose 4’-epimerase enzyme, encoded by gene GALE . Catalyzing the last reaction in…”
Get full text

Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing Approach by Kumar S, Udhaya, Varghese, Rinku Polachirakkal, Preethi, V Anu, Doss, C George Priya, Zayed, Hatem

“…Mutations in the gene are among the most frequent genetic alterations in various cancers, and inhibiting RAS signaling has shown promising results in treating…”
Get full text