Search Results - "Kumar Kanduluru, Ananda"

Ritterostatin GN1N, a Cephalostatin–Ritterazine Bis‐steroidal Pyrazine Hybrid, Selectively Targets GRP78 by Ambrose, Andrew J., Santos, Evelyne A., Jimenez, Paula C., Rocha, Danilo D., Wilke, Diego V., Beuzer, Paolo, Axelrod, Josh, Kumar Kanduluru, Ananda, Fuchs, Philip L., Cang, Hu, Costa‐Lotufo, Letícia V., Chapman, Eli, La Clair, James J.

“…Natural products discovered by using agnostic approaches, unlike rationally designed leads or those obtained through high‐throughput screening, offer the…”
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A convenient aminolysis of esters catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) under solvent-free conditions by Sabot, Cyrille, Kumar, Kanduluru Ananda, Meunier, Stéphane, Mioskowski, Charles

“…Various aliphatic and aromatic esters readily undergo aminolysis in a mild TBD-mediated solvent-free reaction to afford the corresponding amides in good to…”
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DUPA Conjugation of a Cytotoxic Indenoisoquinoline Topoisomerase I Inhibitor for Selective Prostate Cancer Cell Targeting by Roy, Jyoti, Nguyen, Trung Xuan, Kanduluru, Ananda Kumar, Venkatesh, Chelvam, Lv, Wei, Reddy, P. V. Narasimha, Low, Philip S, Cushman, Mark

“…Prostate-specific membrane antigen (PSMA) is overexpressed in most prostate cancer cells while being present at low or undetectable levels in normal cells…”
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Avidity Mechanism of Dendrimer–Folic Acid Conjugates by van Dongen, Mallory A, Silpe, Justin E, Dougherty, Casey A, Kanduluru, Ananda Kumar, Choi, Seok Ki, Orr, Bradford G, Low, Philip S, Banaszak Holl, Mark M

“…Multivalent conjugation of folic acid has been employed to target cells overexpressing folate receptors. Such polymer conjugates have been previously…”
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Triazabicyclodecene:  An Effective Isotope Exchange Catalyst in CDCl3 by Sabot, Cyrille, Kumar, Kanduluru Ananda, Antheaume, Cyril, Mioskowski, Charles

“…We describe the first effective H/D exchange reaction with acidic substrates in CDCl3 at room temperature. The particularly mild reaction conditions involved…”
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A Convergent Total Synthesis of the Potent Cephalostatin/Ritterazine Hybrid -25-epi Ritterostatin GN1N by Kanduluru, Ananda Kumar, Banerjee, Prabal, Beutler, John A, Fuchs, Philip L

“…The convergent synthesis of 25-epi ritterostatin GN1N is described for the first time, starting from hecogenin acetate (HA). Stereoselective dihydroxylation…”
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Synthesis and Evaluation of a Fluorescent Ritterazine–Cephalostatin Hybrid by Kumar, Kanduluru Ananda, La Clair, James J, Fuchs, Philip L

“…The cephalostatin and ritterazine natural products comprise a potent family of bis-steroidal pyrazines that display potent single-digit nanomolar inhibition of…”
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Ritterostatin G N 1 N , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78 by Ambrose, Andrew J, Santos, Evelyne A, Jimenez, Paula C, Rocha, Danilo D, Wilke, Diego V, Beuzer, Paolo, Axelrod, Josh, Kumar Kanduluru, Ananda, Fuchs, Philip L, Cang, Hu, Costa-Lotufo, Letícia V, Chapman, Eli, La Clair, James J

“…Natural products discovered by using agnostic approaches, unlike rationally designed leads or those obtained through high-throughput screening, offer the…”
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Towards a KCC2 blocker pharmacophore model by Lebon, Florence, Pégurier, Cécile, Ledecq, Marie, Mathieu, Benoit, Bosman, Nathalie, Frycia, Anne, Lengelé, Sébastien, Dhurke, Kashinath, Kanduluru, Ananda Kumar, Meunier, Stéphane, Wagner, Alain, Wolff, Christian, Provins, Laurent

“…The first pharmacophore model for KCC2 blockers was identified using a multi-disciplinary approach combining molecular modelling techniques, XRD, NMR, SAR…”
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Benzyl prolinate derivatives as novel selective KCC2 blockers by Pégurier, Cécile, Bosman, Nathalie, Collart, Philippe, Delporte, Marie-Laure, Leclercq, Karine, Lengelé, Sébastien, Kanduluru, Ananda Kumar, Meunier, Stéphane, Pacico, Nathalie, Vadali, Lakshmana Rao, Wagner, Alain, Wolff, Christian, Provins, Laurent

“…The benzyl prolinate 13 has been identified as a potent KCC2 blocker with selectivity versus NKCC1 and favorable ADME properties. It was evaluated in an in…”
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Use of a Single CAR T Cell and Several Bispecific Adapters Facilitates Eradication of Multiple Antigenically Different Solid Tumors by Lee, Yong Gu, Marks, Isaac, Srinivasarao, Madduri, Kanduluru, Ananda Kumar, Mahalingam, Sakkarapalayam M, Liu, Xin, Chu, Haiyan, Low, Philip S

“…: Most solid tumors are comprised of multiple clones that express orthogonal antigens, suggesting that novel strategies must be developed in order to adapt…”
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Targeted recruitment of immune effector cells for rapid eradication of influenza virus infections by Shahriar, Imrul, Kamra, Mohini, Kanduluru, Ananda Kumar, Campbell, Charity Lynn, Nguyen, Thanh Hiep, Srinivasarao, Madduri, Low, Philip S

“…Despite much research, considerable data suggest that influenza virus remains a serious health problem because i) the effectiveness of current vaccines ranges…”
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Development of a Ligand-Targeted Therapeutic Agent for Neurokinin‑1 Receptor Expressing Cancers by Kanduluru, Ananda Kumar, Low, Philip S

“…The neurokinin-1 receptor (NK1R) plays a significant role in the progression and metastasis of several neuroendocrine tumors. Due to its upregulation in these…”
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Design, Synthesis, and Evaluation of a Neurokinin-1 Receptor-Targeted Near-IR Dye for Fluorescence-Guided Surgery of Neuroendocrine Cancers by Kanduluru, Ananda Kumar, Srinivasarao, Madduri, Low, Philip S.

“…The neurokinin-1 receptor (NK1R) is implicated in the growth and metastasis of many tumors, including cancers of the brain (e.g., gliomas, glioblastomas, and…”
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New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange by Rangasamy, Loganathan, Chelvam, Venkatesh, Kanduluru, Ananda Kumar, Srinivasarao, Madduri, Bandara, N. Achini, You, Fei, Orellana, Esteban A, Kasinski, Andrea L, Low, Philip S

“…Although peptides, antibodies/antibody fragments, siRNAs, antisense DNAs, enzymes, and aptamers are all under development as possible therapeutic agents, the…”
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Abstract 3571: Use of a universal CAR T cell plus bispecific adapters to eradicate antigenically heterogeneous tumors by Lee, Yong Gu, Marks, Isaac, Srinivasarao, Madduri, Kanduluru, Ananda Kumar, Mahalingam, Sakkarapalayam M., Chu, Haiyan, Low, Philip S.

“…Chimeric antigen receptor (CAR) T cell therapies have attracted considerable attention because of their abilities to focus the killing power of T cells…”
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Evaluation of a Neurokinin-1 Receptor–Targeted Technetium-99m Conjugate for Neuroendocrine Cancer Imaging by Kanduluru, Ananda Kumar, Srinivasarao, Madduri, Wayua, Charity, Low, Philip S.

“…Purpose Neuroendocrine tumors (NETs) have reasonably high 5-year survival rates when diagnosed at an early stage but are significantly more lethal when…”
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A simple and convenient protocol for the synthesis of seven- and eight-membered phosphorus heterocycles by Kanduluru, Ananda Kumar, Cirandur, Suresh Reddy

“…A simple procedure for the synthesis of eight-membered 6-(2-chloroethyl)/bis(2-chloroethyl)-amino-12-oxo-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxides (3a-b) and…”
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Synthesis and Evaluation of a Novel ^sup 64^Cu- and ^sup 67^Ga-Labeled Neurokinin 1 Receptor Antagonist for in Vivo Targeting of NK1R-Positive Tumor Xenografts by Zhang, Hanwen, Kanduluru, Ananda Kumar, Desai, Pooja, Ahad, Afruja, Carlin, Sean, Tandon, Nidhi, Weber, Wolfgang A, Low, Philip S

“…Neurokinin 1 receptor (NK1R) is expressed in gliomas and neuroendocrine malignancies and represents a promising target for molecular imaging and targeted…”
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Synthesis and Evaluation of a Novel 64Cu- and 67Ga-Labeled Neurokinin 1 Receptor Antagonist for in Vivo Targeting of NK1R-Positive Tumor Xenografts by Zhang, Hanwen, Kanduluru, Ananda Kumar, Desai, Pooja, Ahad, Afruja, Carlin, Sean, Tandon, Nidhi, Weber, Wolfgang A, Low, Philip S

“…Neurokinin 1 receptor (NK1R) is expressed in gliomas and neuroendocrine malignancies and represents a promising target for molecular imaging and targeted…”
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