Search Results - "Kumar, Vijesh"

Estimating and leveraging protein diffusion on ion-exchange resin surfaces by Khanal, Ohnmar, Kumar, Vijesh, Schlegel, Fabrice, Lenhoff, Abraham M.

“…Protein mobility at solid–liquid interfaces can affect the performance of applications such as bioseparations and biosensors by facilitating reorganization of…”
Get full text

Adeno-associated viral capsid stability on anion exchange chromatography column and its impact on empty and full capsid separation by Khanal, Ohnmar, Kumar, Vijesh, Jin, Mi

“…Recombinant adeno-associated viral vector (rAAV) mediated gene therapy is gaining traction in treating genetic disorders. Current rAAV production systems yield…”
Get full text

Collagen 1A1 (COL1A1) Is a Reliable Biomarker and Putative Therapeutic Target for Hepatocellular Carcinogenesis and Metastasis by Ma, Hon-Ping, Chang, Hang-Lung, Bamodu, Oluwaseun Adebayo, Yadav, Vijesh Kumar, Huang, Ting-Yi, Wu, Alexander T H, Yeh, Chi-Tai, Tsai, Shin-Han, Lee, Wei-Hwa

“…Increasing evidence shows that hepatocellular carcinoma (HCC) is a principal cause of cancer-related mortality globally, especially among Asian and African…”
Get full text

Avoiding antibody aggregation during processing: Establishing hold times by Joshi, Varsha, Shivach, Tarun, Kumar, Vijesh, Yadav, Nitin, Rathore, Anurag

“…Aggregation of biotech products used therapeutically, such as antibodies, can contribute to potential immunogenicity of the product. Charge‐based…”
Get full text

NADPH Oxidase Subunit CYBB Confers Chemotherapy and Ferroptosis Resistance in Mesenchymal Glioblastoma via Nrf2/SOD2 Modulation by Su, I-Chang, Su, Yu-Kai, Setiawan, Syahru Agung, Yadav, Vijesh Kumar, Fong, Iat-Hang, Yeh, Chi-Tai, Lin, Chien-Min, Liu, Heng-Wei

“…Glioblastoma multiforme (GBM) is a highly heterogeneous disease with a mesenchymal subtype tending to exhibit more aggressive and multitherapy-resistant…”
Get full text

New insights into bacterial Zn homeostasis and molecular architecture of the metal resistome in soil polluted with nano zinc oxide by Raghavan, Dinesh, Patinharekkara, Sreena Chuvatte, Elampilay, Sheeja Thotten, Payatatti, Vijesh Kumar Illathidath, Charles, Sona, Veeraraghavan, Srinivasan, Kadiyalath, Jayarajan, Vandana, Sajith, Purayil, Subila Kizhakke, Prasadam, Haritha, Anitha, Shalini Jayaraj

“…Accumulation of nano ZnO (nZnO) in soils could be toxic to bacterial communities through disruption of Zn homeostasis. Under such conditions, bacterial…”
Get full text

PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway by Pai, Shin, Yadav, Vijesh Kumar, Kuo, Kuang-Tai, Pikatan, Narpati Wesa, Lin, Chun-Shu, Chien, Ming-Hsien, Lee, Wei-Hwa, Hsiao, Michael, Chiu, Shao-Chih, Yeh, Chi-Tai, Tsai, Jo-Ting

“…: Oral squamous cell carcinoma (OSCC) has a high prevalence and predicted global mortality rate of 67.1%, necessitating better therapeutic strategies…”
Get full text

The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis by Chuang, Hao-Yu, Hsu, Li-Yun, Pan, Chih-Ming, Pikatan, Narpati Wesa, Yadav, Vijesh Kumar, Fong, Iat-Hang, Chen, Chao-Hsuan, Yeh, Chi-Tai, Chiu, Shao-Chih

“…Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. It is highly resistant to chemotherapy, and tumor recurrence is common. Neuronal…”
Get full text

Computational analysis for identification of the extracellular matrix molecules involved in endometrial cancer progression by Yadav, Vijesh Kumar, Lee, Tzong-Yi, Hsu, Justin Bo-Kai, Huang, Hsien-Da, Yang, Wei-Chung Vivian, Chang, Tzu-Hao

“…Recurrence and poorly differentiated (grade 3 and above) and atypical cell type endometrial cancer (EC) have poor prognosis outcome. The mechanisms and…”
Get full text

Novel NFκB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling by Weng, Pei-Wei, Yadav, Vijesh Kumar, Pikatan, Narpati Wesa, Fong, Iat-Hang, Lin, I-Hsin, Yeh, Chi-Tai, Lee, Wei-Hwa

“…Osteoarthritis (OA) is a common articular disease manifested by the destruction of cartilage and compromised chondrogenesis in the aging population, with…”
Get full text

In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1 by Khedkar, Harshita Nivrutti, Wang, Yu-Chi, Yadav, Vijesh Kumar, Srivastava, Prateeti, Lawal, Bashir, Mokgautsi, Ntlotlang, Sumitra, Maryam Rachmawati, Wu, Alexander T. H., Huang, Hsu-Shan

“…Ovarian cancer is often detected at the advanced stages at the time of initial diagnosis. Early-stage diagnosis is difficult due to its asymptomatic nature,…”
Get full text

Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis by Weng, Pei-Wei, Pikatan, Narpati Wesa, Setiawan, Syahru Agung, Yadav, Vijesh Kumar, Fong, Iat-Hang, Hsu, Chia-Hung, Yeh, Chi-Tai, Lee, Wei-Hwa

“…Osteoarthritis (OA) is most prevalent in older individuals and exerts a heavy social and economic burden. However, an effective and noninvasive approach to OA…”
Get full text

PAICS/DYRK3 Multienzyme Interactions as Coregulators of Purinosome Formation and Metabolism on Radioresistance in Oral Squamous Cell Carcinoma by Huang, Chin-Sheng, Hsieh, Ming-Shou, Yadav, Vijesh Kumar, Wu, Yang-Che, Liu, Shao-Cheng, Yeh, Chi-Tai, Huang, Mao-Suan

“…Oral squamous cell carcinoma (OSCC) is a prevalent type of oral cancer. While therapeutic innovations have made strides, radioresistance persists as a…”
Get full text

4-Acetyl-Antroquinonol B Improves the Sensitization of Cetuximab on Both Kras Mutant and Wild Type Colorectal Cancer by Modulating the Expression of Ras/Raf/miR-193a-3p Signaling Axis by Chu, Yi Cheng, Tsai, Tung-Yao, Yadav, Vijesh Kumar, Deng, Li, Huang, Chun-Chih, Tzeng, Yew-Min, Yeh, Chi-Tai, Chen, Ming-Yao

“…The KRAS mutation is one of the leading driver mutations in colorectal cancer (CRC), and it is usually associated with poor prognosis and drug resistance…”
Get full text

HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer by Kuo, Kuang-Tai, Lin, Cheng-Hsin, Wang, Chun-Hua, Pikatan, Narpati Wesa, Yadav, Vijesh Kumar, Fong, Iat-Hang, Yeh, Chi-Tai, Lee, Wei-Hwa, Huang, Wen-Chien

“…The treatment of non-small-cell lung cancer (NSCLC) involves platinum-based chemotherapy. It is typically accompanied by chemoresistance resulting from…”
Get full text

Targeting the SREBP-1/Hsa-Mir-497/SCAP/FASN Oncometabolic Axis Inhibits the Cancer Stem-like and Chemoresistant Phenotype of Non-Small Cell Lung Carcinoma Cells by Tiong, Tung-Yu, Weng, Pei-Wei, Wang, Chun-Hua, Setiawan, Syahru Agung, Yadav, Vijesh Kumar, Pikatan, Narpati Wesa, Fong, Iat-Hang, Yeh, Chi-Tai, Hsu, Chia-Hung, Kuo, Kuang-Tai

“…Background: Lung cancer remains a leading cause of cancer-related death, with an annual global mortality rate of 18.4%. Despite advances in diagnostic and…”
Get full text

Furanocoumarin Notopterol: Inhibition of Hepatocellular Carcinogenesis through Suppression of Cancer Stemness Signaling and Induction of Oxidative Stress-Associated Cell Death by Huang, Ting-Yun, Yang, Ching-Kuo, Chen, Ming-Yao, Yadav, Vijesh Kumar, Fong, Iat-Hang, Yeh, Chi-Tai, Cherng, Yih-Giun

“…Hepatocellular carcinoma (HCC) remains an aggressive malignancy with a poor prognosis and a leading cause of cancer-related mortality globally. Cumulative…”
Get full text

Gene expression analysis in drought tolerant and susceptible black pepper (Piper nigrum L.) in response to water deficit stress by George, K. Johnson, Malik, Neema, Vijesh Kumar, I. P., Krishnamurthy, K. S.

“…Drought or water deficit stress is one of the main environmental stresses affecting plants, resulting in reduced productivity and crop loss. Black pepper, a…”
Get full text

Structure-based strategies for synthesis, lead optimization and biological evaluation of N-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as potential multi-target anticancer agents by Ali, Ahmed Atef Ahmed, Lee, Yu-Ru, Wu, Alexander T.H., Yadav, Vijesh Kumar, Yu, Dah-Shyong, Huang, Hsu-Shan

“…[Display omitted] As part of our research on developing multi-target small molecule anticancer agents, we designed, synthesized, and biologically evaluated a…”
Get full text

Notopterol mitigates IL-1β-triggered pyroptosis by blocking NLRP3 inflammasome via the JAK2/NF-kB/hsa-miR-4282 route in osteoarthritis by Chen, Ko-Ta, Yeh, Chi-Tai, Yadav, Vijesh Kumar, Pikatan, Narpati Wesa, Fong, Iat-Hang, Lee, Wei-Hwa, Chiu, Yen-Shuo

“…Osteoarthritis (OA), the most prevalent form of arthritis, impacts approximately 10% of men and 18% of women aged above 60 years. Currently, a complete cure…”
Get full text