Search Results - "Kumar, Vathan"

Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors by Chang, Chih-Shiang, Kumar, Vathan, Lee, Der-Yen, Chen, Yeh, Wu, Yu-Chieh, Gao, Jing-Yan, Chu, Po-Chen

“…A growing body of evidence suggests that Hsp70, which is overexpressed in human breast tumors, plays a role in tumorigenesis and tumor progression in breast…”
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Anti-SARS coronavirus agents: a patent review (2008 - present) by Kumar, Vathan, Jung, Young-Sik, Liang, Po-Huang

“…A novel coronavirus (CoV), unlike previous typical human coronaviruses (HCoVs), was identified as causative agent for severe acute respiratory syndrome (SARS)…”
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Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors by Kumar, Vathan, Tan, Kian-Pin, Wang, Ying-Ming, Lin, Sheng-Wei, Liang, Po-Huang

“…[Display omitted] Severe acute respiratory syndrome (SARS) led to a life-threatening form of atypical pneumonia in late 2002. Following that, Middle East…”
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Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2 by Chen, Yeh, Yang, Wen-Hao, Chen, Hsiao-Fan, Huang, Li-Min, Gao, Jing-Yan, Lin, Cheng-Wen, Wang, Yu-Chuan, Yang, Chia-Shin, Liu, Yi-Liang, Hou, Mei-Hui, Tsai, Chia-Ling, Chou, Yi-Zhen, Huang, Bao-Yue, Hung, Chian-Fang, Hung, Yu-Lin, Wang, Wei-Jan, Su, Wen-Chi, Kumar, Vathan, Wu, Yu-Chieh, Chao, Shih-Wei, Chang, Chih-Shiang, Chen, Jin-Shing, Chiang, Yu-Ping, Cho, Der-Yang, Jeng, Long-Bin, Tsai, Chang-Hai, Hung, Mien-Chie

“…The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has severely affected human lives around the world as well as the global…”
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Disrupting CCT-β : β-tubulin selectively kills CCT-β overexpressed cancer cells through MAPKs activation by Liu, Yan-Jin, Kumar, Vathan, Lin, Yuan-Feng, Liang, Po-Huang

“…We have previously demonstrated the ability of I-Trp to disrupt the protein–protein interaction of β -tubulin with chaperonin-containing TCP-1 β (CCT- β )…”
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Development of triazole-based PKC-inhibitors to overcome resistance to EGFR inhibitors in EGFR-mutant lung cancers by Lee, Pei-Chih, Kumar, Vathan, Sivakumar, Govindan, Tseng, Tzu-Yu, Li, Yi-Chuan, Jiang, Yu-Cyuan, Hsiao, Yu-Chun, Lin, Hsiang-Wen, Chang, Chih-Shiang, Hung, Mien-Chie

“…Protein kinase C delta (PKCδ) is prominently expressed in the nuclei of EGFR-mutant lung cancer cells, and its presence correlates with poor survival of the…”
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Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors by Kumar, Vathan, Shin, Jin Soo, Shie, Jiun-Jie, Ku, Keun Bon, Kim, Chonsaeng, Go, Yun Young, Huang, Kai-Fa, Kim, Meehyein, Liang, Po-Huang

“…Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness with fever, cough and shortness of breath. Up to date, it has…”
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Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CL Pro inhibitors by Kumar, Vathan, Shin, Jin Soo, Shie, Jiun-Jie, Ku, Keun Bon, Kim, Chonsaeng, Go, Yun Young, Huang, Kai-Fa, Kim, Meehyein, Liang, Po-Huang

“…Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness with fever, cough and shortness of breath. Up to date, it has…”
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Identification, Synthesis, and Evaluation of New Neuraminidase Inhibitors by Kumar, Vathan, Chang, Chih-Kang, Tan, Kian-Pin, Jung, Young-Sik, Chen, Shih-Hsun, Cheng, Yih-Shyun E, Liang, Po-Huang

“…High-throughput screening was performed on ∼6800 compounds to identify KR-72039 as an inhibitor of H1N1 and H5N1 neuraminidases (NAs). Structure–activity…”
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Disrupting CCT-[beta] : [beta]-tubulin selectively kills CCT-[beta] overexpressed cancer cells through MAPKs activation by Liu, Yan-jin, Kumar, Vathan, Lin, Yuan-feng, Liang, Po-huang

“…We have previously demonstrated the ability of I-Trp to disrupt the protein-protein interaction of β-tubulin with chaperonin-containing TCP-1β (CCT-β). This…”
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Synthesis and Evaluation of Novel Pyrimidine Derivatives for their Biological Activity by Kumar, Vathan

“…Various substituted aldehydes were treated with p‐ nitroacetophenone to give corresponding 1,3‐diaryl‐2‐ propene‐1‐ones. Condensation of these chalcones with…”
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