Search Results - "Kumar, Parvin"
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Quantitative structure–activity relationship modeling for predication of inhibition potencies of imatinib derivatives using SMILES attributes
Published in Scientific reports (15-12-2022)“…Chronic myelogenous leukemia (CML) which is resulted from the BCR-ABL tyrosine kinase (TK) chimeric oncoprotein, is a malignant clonal disorder of…”
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Deep learning and multi-omics approach to predict drug responses in cancer
Published in BMC bioinformatics (28-11-2022)“…Cancers are genetically heterogeneous, so anticancer drugs show varying degrees of effectiveness on patients due to their differing genetic profiles. Knowing…”
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Network-based integration of multi-omics data for clinical outcome prediction in neuroblastoma
Published in Scientific reports (14-09-2022)“…Multi-omics data are increasingly being gathered for investigations of complex diseases such as cancer. However, high dimensionality, small sample size, and…”
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Proficient exclusion of pesticide using humic acid-modified magnetite nanoparticles from aqueous solution
Published in Water science and technology (01-12-2022)“…Extensive dispersal of the pesticides to shield the different types of vegetation from pests has increased the production but at the same it has resulted in an…”
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A review of antimalarial activity of two or three nitrogen atoms containing heterocyclic compounds
Published in Medicinal chemistry research (01-10-2020)“…Malaria, a nocuous disease, which has become a major challenge for the health resulting in deaths of millions of people around the globe. Malaria is a…”
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Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents
Published in BMC chemistry (14-11-2017)“…Background Acyl hydrazones are an important class of heterocyclic compounds promising pharmacological characteristics. Malaria is a life-threatening…”
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Exploring the Multitarget Potential of Iridoids: Advances and Applications
Published in Current topics in medicinal chemistry (01-01-2023)“…Iridoids are secondary plant metabolites that are multitarget compounds active against various diseases. Iridoids are structurally classified into iridoid…”
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Multicellular target QSAR models for predicting of novel inhibitors against pancreatic cancer by Monte Carlo approach
Published in Results in Chemistry (01-08-2024)“…[Display omitted] Pancreatic cancer is one of the most fatal malignant tumors, with a poor prognosis. Nowadays, computational methods for designing and…”
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In-silico activity prediction and docking studies of some flavonol derivatives as anti-prostate cancer agents based on Monte Carlo optimization
Published in BMC chemistry (26-07-2023)“…The QSAR models are employed to predict the anti-proliferative activity of 81 derivatives of flavonol against prostate cancer using the Monte Carlo algorithm…”
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Plasma contact system activation drives anaphylaxis in severe mast cell–mediated allergic reactions
Published in Journal of allergy and clinical immunology (01-04-2015)“…Background Anaphylaxis is an acute, potentially lethal, multisystem syndrome resulting from the sudden release of mast cell–derived mediators into the…”
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Serum Gamma glutamyltransferase (GGT) in coronary artery disease: Exploring the Asian Indian connection
Published in Indian heart journal (01-12-2021)Get full text
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Remediation of toluidine blue O dye from aqueous solution using surface functionalized magnetite nanoparticles
Published in Water practice and technology (01-04-2024)“…Abstract In the current study, tannic acid-functionalized iron oxide nanoparticles have been synthesized using a cost-effective co-precipitation method and…”
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Physical exercise is associated with a reduction in plasma levels of fractalkine, TGF-β1, eotaxin-1 and IL-6 in younger adults with mobility disability
Published in PloS one (2022)“…Mobility disability (MD) refers to substantial limitations in life activities that arise because of movement impairments. Although MD is most prevalent in…”
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Hydroxyenone Derivatives: In vitro Anti-malarial and Docking Studies against P. falciparum
Published in Infectious disorders drug targets (2020)“…A series of 1-{2-(prop-2-ynyloxy)aryl}-3-hydroxy-3-(4'-trifluoromethylphenyl) prop-2-en-1-ones obtained by photo-irradiation of…”
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Plasma GDF15 level is elevated in psychosis and inversely correlated with severity
Published in Scientific reports (11-08-2017)“…Accumulating evidence suggests that GDF15 is a biomarker for ageing and morbidity of many somatic disorders such as cancer and inflammatory disorders…”
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Estrogenic and Anti-Alzheimer’s studies of Zingiber officinalis as well as Amomum subulatum Roxb.: the success story of dry techniques
Published in Medicinal chemistry research (01-03-2015)“…The extracts of ginger and cardamom were chosen for studies on estrogen receptors and Alzheimer’s disease on the basis of various in silico studies of their…”
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An efficient synthesis of pyrazole chalcones under solvent free conditions at room temperature
Published in Chinese chemical letters (2011)“…An easy, safe, solvent free and effective method for the synthesis of pyrazole-substituted chalcones has been achieved by grinding pyrazole aldehydes and…”
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Cytotoxicity of quantum dots: Use of quasiSMILES in development of reliable models with index of ideality of correlation and the consensus modelling
Published in Journal of hazardous materials (15-01-2021)“…[Display omitted] •Toxicity of quantum dots is a major concern due to advances in medical applications.•QuasiSMILES has potential for modelling cytotoxicity of…”
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A green and convenient synthesis of 2-aroylbenzofurans in aqueous media
Published in Arabian journal of chemistry (01-05-2017)“…A green and convenient synthesis of some 2-aroylbenzofurans has been developed via the Rap-Stoermer type reaction between o-hydroxyacetophenones and…”
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CORAL: QSAR models of CB1 cannabinoid receptor inhibitors based on local and global SMILES attributes with the index of ideality of correlation and the correlation contradiction index
Published in Chemometrics and intelligent laboratory systems (15-05-2020)“…Obesity has acquired notable attention due to its high occurrence and link with grievous health problems such as hypertension, diabetes and heart disease. It…”
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