Search Results - "Kumar, Janesh"

Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture by Burada, Ananth Prasad, Vinnakota, Rajesh, Kumar, Janesh

“…Ionotropic orphan delta (GluD) receptors are not gated by glutamate or any other endogenous ligand but are grouped with ionotropic glutamate receptors (iGluRs)…”
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Functional insights from glutamate receptor ion channel structures by Kumar, Janesh, Mayer, Mark L

“…X-ray crystal structures for the soluble amino-terminal and ligand-binding domains of glutamate receptor ion channels, combined with a 3.6-Å-resolution…”
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Recent Insights into the Structure and Function of Mycobacterial Membrane Proteins Facilitated by Cryo-EM by Bendre, Ameya D., Peters, Peter J., Kumar, Janesh

“…Mycobacterium tuberculosis (Mtb) is one of the deadliest pathogens encountered by humanity. Over the decades, its characteristic membrane organization and…”
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Structural mechanism of glutamate receptor activation and desensitization by Meyerson, Joel R., Kumar, Janesh, Chittori, Sagar, Rao, Prashant, Pierson, Jason, Bartesaghi, Alberto, Mayer, Mark L., Subramaniam, Sriram

“…Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synaptic transmission in the vertebrate brain. To gain a better…”
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Functional implications of the exon 9 splice insert in GluK1 kainate receptors by Dhingra, Surbhi, Chopade, Prachi M, Vinnakota, Rajesh, Kumar, Janesh

“…Kainate receptors are key modulators of synaptic transmission and plasticity in the central nervous system. Different kainate receptor isoforms with distinct…”
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Structure and Assembly Mechanism for Heteromeric Kainate Receptors by Kumar, Janesh, Schuck, Peter, Mayer, Mark L.

“…Native glutamate receptor ion channels are tetrameric assemblies containing two or more different subunits. NMDA receptors are obligate heteromers formed by…”
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An overview of the recent advances in cryo-electron microscopy for life sciences by Assaiya, Anshul, Burada, Ananth Prasad, Dhingra, Surbhi, Kumar, Janesh

“…Cryo-electron microscopy (CryoEM) has superseded X-ray crystallography and NMR to emerge as a popular and effective tool for structure determination in recent…”
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Hysteroscopic local anesthetic intrauterine cornual block in office endometrial ablation: a randomized controlled trial by Kumar, Vinod, Ph.D, Tryposkiadis, Konstantinos, M.Sc, Gupta, Janesh Kumar, M.D

“…Objective To evaluate the efficacy of a hysteroscopic local anesthetic intrauterine cornual block (ICOB) on pain experienced during office endometrial ablation…”
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The N-terminal domain of GluR6-subtype glutamate receptor ion channels by Schuck, Peter, Kumar, Janesh, Jin, Rongsheng, Mayer, Mark L

“…The amino-terminal domain (ATD) of ionotropic glutamate receptors (iGluRs) mediates their assembly into AMPA-, kainate- and NMDA-sensitive subtypes. The…”
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Role of actin cytoskeleton in the organization and function of ionotropic glutamate receptors by Dutta, Priyanka, Bharti, Pratibha, Kumar, Janesh, Maiti, Sankar

“…Neural networks with precise connection are compulsory for learning and memory. Various cellular events occur during the genesis of dendritic spines to their…”
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A highly conserved protein of unknown function in Sinorhizobium meliloti affects sRNA regulation similar to Hfq by Pandey, Shree P., Minesinger, Brenda K., Kumar, Janesh, Walker, Graham C.

“…The SMc01113/YbeY protein, belonging to the UPF0054 family, is highly conserved in nearly every bacterium. However, the function of these proteins still…”
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CASSPER is a semantic segmentation-based particle picking algorithm for single-particle cryo-electron microscopy by George, Blesson, Assaiya, Anshul, Roy, Robin J., Kembhavi, Ajit, Chauhan, Radha, Paul, Geetha, Kumar, Janesh, Philip, Ninan S.

“…Particle identification and selection, which is a prerequisite for high-resolution structure determination of biological macromolecules via single-particle…”
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Tuberculosis: Past, present and future of the treatment and drug discovery research by Bendre, Ameya D., Peters, Peter J., Kumar, Janesh

“…Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Despite decades of research driving advancements in drug…”
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Endometrial ablation for heavy menstrual bleeding by Kumar, Vinod, Chodankar, Rohan, Gupta, Janesh Kumar

“…Endometrial ablation can be described as one of the great gynecological success stories. It has changed the management of heavy menstrual bleeding…”
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Analysis of high-affinity assembly for AMPA receptor amino-terminal domains by Zhao, Huaying, Berger, Anthony J, Brown, Patrick H, Kumar, Janesh, Balbo, Andrea, May, Carrie A, Casillas, Jr, Ernesto, Laue, Thomas M, Patterson, George H, Mayer, Mark L, Schuck, Peter

“…Analytical ultracentrifugation (AUC) and steady-state fluorescence anisotropy were used to measure the equilibrium dissociation constant (Kd) for formation of…”
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Self-assembled monolayers improve protein distribution on holey carbon cryo-EM supports by Meyerson, Joel R., Rao, Prashant, Kumar, Janesh, Chittori, Sagar, Banerjee, Soojay, Pierson, Jason, Mayer, Mark L., Subramaniam, Sriram

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Levonorgestrel-releasing intrauterine system vs. usual medical treatment for menorrhagia: an economic evaluation alongside a randomised controlled trial by Sanghera, Sabina, Roberts, Tracy Elizabeth, Barton, Pelham, Frew, Emma, Daniels, Jane, Middleton, Lee, Gennard, Laura, Kai, Joe, Gupta, Janesh Kumar

“…To undertake an economic evaluation alongside the largest randomised controlled trial comparing Levonorgestrel-releasing intrauterine device ('LNG-IUS') and…”
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Ionotropic glutamate delta receptors: The enigma has finally begun to unravel by Kumar, Janesh

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Domain organization and function in GluK2 subtype kainate receptors by Das, Utpal, Kumar, Janesh, Mayer, Mark L, Plested, Andrew J.R

“…Glutamate receptor ion channels (iGluRs) are excitatory neurotransmitter receptors with a unique molecular architecture in which the extracellular domains…”
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Benign prostatic hyperplasia. Part 2—Management by Wilt, Timothy J, N’Dow, James

“…Surgery provides the largest improvement in symptom score (on the American Urological Association's international prostate symptom scale), with minimally…”
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