Search Results - "Kumar, Anita V"

Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging by Kumar, Anita V, Mills, Joslyn, Lapierre, Louis R

“…Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a…”
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Non-canonical autophagy in aging and age-related diseases by Kumar, Anita V, Mills, Joslyn

“…Autophagy, one of the arms of proteostasis, influences aging and age-related diseases. Recently, the discovery of additional roles of autophagy-related…”
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Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan by Silvestrini, Melissa J., Johnson, Joseph R., Kumar, Anita V., Thakurta, Tara G., Blais, Karine, Neill, Zachary A., Marion, Sarah W., St. Amand, Victoria, Reenan, Robert A., Lapierre, Louis R.

“…Transcriptional modulation of the process of autophagy involves the transcription factor HLH-30/TFEB. In order to systematically determine the regulatory…”
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Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans by Kumar, Anita V., Mills, Joslyn, Parker, Wesley M., Leitão, Joshua A., Rodriguez, Diego I., Daigle, Sandrine E., Ng, Celeste, Patel, Rishi, Aguilera, Joseph L., Johnson, Joseph R., Wong, Shi Quan, Lapierre, Louis R.

“…In several long-lived Caenorhabditis elegans strains, such as insulin/IGF-1 receptor daf-2 mutants, enhanced proteostatic mechanisms are accompanied by…”
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Autophagy in aging and longevity by Wong, Shi Q., Kumar, Anita V., Mills, Joslyn, Lapierre, Louis R.

“…Our understanding of the process of autophagy and its role in health and diseases has grown remarkably in the last two decades. Early work established…”
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Tubulobulbar complex: cytoskeletal remodeling to release spermatozoa by Upadhyay, Rahul D, Kumar, Anita V, Ganeshan, Malti, Balasinor, Nafisa H

“…Tubulobulbar complexes (TBCs) are actin-based structures that help establish close contact between Sertoli-Sertoli cells or Sertoli-mature germ cells…”
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Sex hormones regulate lipid metabolism in adult Sertoli cells: A genome-wide study of estrogen and androgen receptor binding sites by Raut, Sanketa, Kumar, Anita V., Deshpande, Sharvari, Khambata, Kushaan, Balasinor, Nafisa H.

“…•This is the first study to investigate estrogen and androgen binding sites in Sertoli cells under unperturbed conditions, using ChIP-Seq.•Pathway analysis of…”
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Genome-wide identification of estrogen receptor binding sites reveals novel estrogen-responsive pathways in adult male germ cells by Raut, Sanketa, Kumar, Anita V, Khambata, Kushaan, Deshpande, Sharvari, Balasinor, Nafisa H

“…Spermatogenesis occurs in the seminiferous epithelium that shows the presence of estrogen receptors alpha (ERα) and beta (ERβ), both of which regulate gene…”
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Location, location, location: subcellular protein partitioning in proteostasis and aging by Kumar, Anita V., Lapierre, Louis R.

“…Somatic maintenance and cell survival rely on proper protein homeostasis to ensure reliable functions across the cell and to prevent proteome collapse…”
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Proteomics in reproductive biology: Beacon for unraveling the molecular complexities by Upadhyay, Rahul D., Balasinor, N.H., Kumar, Anita V., Sachdeva, Geetanjali, Parte, Priyanka, Dumasia, Kushaan

“…Proteomics, an interface of rapidly evolving advances in physics and biology, is rapidly developing and expanding its potential applications to molecular and…”
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Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP by Kumar, Anita V, Kang, Taewook, Thakurta, Tara G, Ng, Celeste, Rogers, Aric N, Larsen, Martin R, Lapierre, Louis R

“…Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear…”
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C. elegans to model autophagy-related human disorders by Wong, Shi Quan, Kumar, Anita V, Mills, Joslyn, Lapierre, Louis R

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Estrogen effects on actin cytoskeletal and endocytic proteins associated with tubulobulbar complex disruption in rat testes by Upadhyay, Rahul D, Kumar, Anita V, Sonawane, Shobha, Gaonkar, Reshma, Balasinor, Nafisa H

“…Tubulobulbar complexes (TBCs), evaginations of mature spermatids, penetrate into the surrounding Sertoli cell cytoplasm of testis seminiferous epithelium…”
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