Search Results - "Kumar, Aditya R"

Abundance of P‐Glycoprotein and Other Drug Transporters at the Human Blood‐Brain Barrier in Alzheimer’s Disease: A Quantitative Targeted Proteomic Study by Storelli, Flavia, Billington, Sarah, Kumar, Aditya R., Unadkat, Jashvant D.

“…The human blood‐brain barrier (BBB) transporter P‐gp can efflux amyloid‐β (Aβ) out of the central nervous system (CNS). Aβ is thought to be the causative agent…”
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Predicting Human Fetal Drug Exposure Through Maternal‐Fetal PBPK Modeling and In Vitro or Ex Vivo Studies by Balhara, Ankit, Kumar, Aditya R., Unadkat, Jashvant D.

“…Medication (drug) use in human pregnancy is prevalent. Determining fetal safety and efficacy of drugs is logistically challenging. However, predicting (not…”
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Mechanisms of Transplacental Transfer of (‐)‐∆ 9‐Tetrahydrocannabinol (THC) in the Human Dual Cotyledon, Dual Perfusion, Placenta Model by Kumar, Aditya R., Ieronimakis, Nicholas, Unadkat, Jashvant D.

“…Background (‐)‐∆ 9‐Tetrahydrocannabinol (THC) is the most abundant psychoactive compound in marijuana. With legalization of marijuana, its use has increased…”
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The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans by Storelli, Flavia, Yin, Mengyue, Kumar, Aditya R, Ladumor, Mayur K, Evers, Raymond, Chothe, Paresh P, Enogieru, Osatohanmwen J, Liang, Xiaomin, Lai, Yurong, Unadkat, Jashvant D

“…Predicting transporter-based drug clearance (CL) and tissue concentrations (TC) in humans is important to reduce the risk of failure during drug development…”
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In Vivo-to-In Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach by Kumar, Aditya R, Prasad, Bhagwat, Bhatt, Deepak Kumar, Mathialagan, Sumathy, Varma, Manthena V S, Unadkat, Jashvant D

“…About 30% of approved drugs are cleared predominantly by renal clearance (CL ). Of these, many are secreted by transporters. For these drugs, in vitro-to-in…”
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Characterizing and Quantifying Extrahepatic Metabolism of (-)-Δ 9 -Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ 9 -THC (11-OH-THC) by Kumar, Aditya R, Patilea-Vrana, Gabriela I, Anoshchenko, Olena, Unadkat, Jashvant D

“…(-)-Δ -Tetrahydrocannabinol (THC) is the psychoactive constituent of cannabis, a drug recreationally consumed orally or by inhalation. Physiologically based…”
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Characterizing and Quantifying Extrahepatic Metabolism of (-)-Δ9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ9-THC (11-OH-THC) by Kumar, Aditya R, Patilea-Vrana, Gabriela I, Anoshchenko, Olena, Unadkat, Jashvant D

“…(−)-Δ 9 -Tetrahydrocannabinol (THC) is the psychoactive constituent of cannabis, a drug recreationally consumed orally or by inhalation. Physiologically based…”
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Understanding the Mechanism and Extent of Transplacental Transfer of (−)‐∆9‐Tetrahydrocannabinol (THC) in the Perfused Human Placenta to Predict In Vivo Fetal THC Exposure by Kumar, Aditya R., Sheikh, Emily D., Monson, Joshua W., Ligon, Sarah E., Talley, Rebecca L., Dornisch, Elisabeth M., Howitz, Kamy J., Damicis, Jennifer R., Ieronimakis, Nicholas, Unadkat, Jashvant D.

“…Cannabis use during pregnancy may cause fetal toxicity driven by in utero exposure to (−)‐∆9‐tetrahydrocannabinol (THC) and its psychoactive metabolite,…”
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Pharmacokinetics of dacarbazine (DTIC) in pregnancy by Kantrowitz-Gordon, Ira, Hays, Karen, Kayode, Olumide, Kumar, Aditya R., Kaplan, Henry G., Reid, Joel M., Safgren, Stephanie L., Ames, Matthew M., Easterling, Thomas R., Hebert, Mary F.

“…Purpose The purpose of this report is to describe, for the first time, the pharmacokinetics of dacarbazine (DTIC) and its metabolites…”
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In Vitro–to–In Vivo Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach by Kumar, Aditya R., Prasad, Bhagwat, Bhatt, Deepak Kumar, Mathialagan, Sumathy, Varma, Manthena V. S., Unadkat, Jashvant D.

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Assessing THC passage and the impact in human perfused placenta cotyledons by Sheikh, Emily, Kumar, Aditya R., Leonard, Katherine M., Monson, Joshua, McCormick, Sarah, Pates, Jason, Napolitano, Peter, Unadkat, Jashvant D., Ieronimakis, Nicholas

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Quantification and Prediction of Human Fetal (-)-Δ9-Tetrahydrocannabinol (THC)/11-OH-THC Exposure to Inform Neurodevelopmental Toxicity of Cannabis by Kumar, Aditya R

“…Prenatal cannabis use is associated with various detrimental outcomes in the offspring, the foremost being neurodevelopmental toxicity. Δ9-tetrahydrocannabinol…”
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Recent advances in drug transporter sciences: highlights from the year 2020 by Chothe, Paresh P., Nakakariya, Masanori, Rotter, Charles J., Sandoval, Philip, Tohyama, Kimio

“…Drug Metabolism Reviews has an impressive track record of providing scientific reviews in the area of xenobiotic biotransformation over 47 years. It has…”
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