Search Results - "Kum Kum Khanna"

A Comprehensive Review on Current Advances in Peptide Drug Development and Design by Lee, Andy Chi-Lung, Harris, Janelle Louise, Khanna, Kum Kum, Hong, Ji-Hong

“…Protein-protein interactions (PPIs) execute many fundamental cellular functions and have served as prime drug targets over the last two decades. Interfering…”
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From selenium to selenoproteins: synthesis, identity, and their role in human health by Papp, Laura Vanda, Lu, Jun, Holmgren, Arne, Khanna, Kum Kum

“…The requirement of the trace element selenium for life and its beneficial role in human health has been known for several decades. This is attributed to low…”
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Serendipity, luck and hard work by Khanna, Kum Kum

“…Professor Kum Kum Khanna heads the Signal Transduction Laboratory at the QIMR Berghofer Medical Research Institute in Brisbane, Australia. She studies the role…”
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Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease by Kalimutho, Murugan, Parsons, Kate, Mittal, Deepak, López, J. Alejandro, Srihari, Sriganesh, Khanna, Kum Kum

“…Triple-negative breast cancers (TNBCs) constitute a heterogeneous subtype of breast cancers that have a poor clinical outcome. Although no approved targeted…”
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The Integrator complex controls the termination of transcription at diverse classes of gene targets by Skaar, Jeffrey R, Ferris, Andrea L, Wu, Xiaolin, Saraf, Anita, Khanna, Kum Kum, Florens, Laurence, Washburn, Michael P, Hughes, Stephen H, Pagano, Michele

“…Complexes containing INTS3 and either NABP1 or NABP2 were initially characterized in DNA damage responses, but their biochemical function remained unknown…”
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Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions by Tomimatsu, Nozomi, Mukherjee, Bipasha, Deland, Katherine, Kurimasa, Akihiro, Bolderson, Emma, Khanna, Kum Kum, Burma, Sandeep

“…The resection of DNA double-strand breaks (DSBs) to generate ssDNA tails is a pivotal event in the cellular response to these breaks. In the two-step model of…”
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Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice by Tomimatsu, Nozomi, Mukherjee, Bipasha, Catherine Hardebeck, Molly, Ilcheva, Mariya, Vanessa Camacho, Cristel, Louise Harris, Janelle, Porteus, Matthew, Llorente, Bertrand, Khanna, Kum Kum, Burma, Sandeep

“…Resection of DNA double-strand breaks (DSBs) is a pivotal step during which the choice between NHEJ and HR DNA repair pathways is made. Although CDKs are known…”
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Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51 by Ward, Ambber, Khanna, Kum Kum, Wiegmans, Adrian P

“…Highlights • We have examined the mechanisms of therapy resistance mediated by cancer genome stabilization. • We assess the targeting of RAD51 to overcome…”
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Defining the relationship between cellular and extracellular vesicle (EV) content in breast cancer via an integrative multi‐omic analysis by Lane, Rebecca E., Korbie, Darren, Khanna, Kum Kum, Mohamed, Ahmed, Hill, Michelle M., Trau, Matt

“…Much recent research has been dedicated to exploring the utility of extracellular vesicles (EVs) as circulating disease biomarkers. Underpinning this work is…”
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Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis by Mittal, Deepak, Sinha, Debottam, Barkauskas, Deborah, Young, Arabella, Kalimutho, Murugan, Stannard, Kimberley, Caramia, Franco, Haibe-Kains, Benjamin, Stagg, John, Khanna, Kum Kum, Loi, Sherene, Smyth, Mark J

“…Adenosine plays an important role in inflammation and tumor development, progression, and responses to therapy. We show that an adenosine 2B receptor inhibitor…”
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Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti‐PD‐L1 antibody for treatment of triple‐negative breast cancer by Raninga, Prahlad V., Lee, Andy C., Sinha, Debottam, Shih, Yu‐Yin, Mittal, Deepak, Makhale, Ashwini, Bain, Amanda L., Nanayakarra, Devathri, Tonissen, Kathryn F., Kalimutho, Murugan, Khanna, Kum Kum

“…Triple‐negative breast cancer (TNBCs) is a very aggressive and lethal form of breast cancer with no effective targeted therapy. Neoadjuvant chemotherapies and…”
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Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis by Rashidieh, Behnam, Shohayeb, Belal, Bain, Amanda Louise, Fortuna, Patrick R. J, Sinha, Debottam, Burgess, Andrew, Mills, Richard, Adams, Rachael C, Lopez, J. Alejandro, Blumbergs, Peter, Finnie, John, Kalimutho, Murugan, Piper, Michael, Hudson, James Edward, Ng, Dominic C. H, Khanna, Kum Kum

“…Homozygous nonsense mutations in CEP55 are associated with several congenital malformations that lead to perinatal lethality suggesting that it plays a…”
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CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer by Makhale, Ashwini, Nanayakkara, Devathri, Raninga, Prahlad, Khanna, Kum Kum, Kalimutho, Murugan

“…Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking targeted therapy. Here, we evaluated the anti-cancer activity of…”
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Optimizing poly (ADP‐ribose) polymerase inhibition through combined epigenetic and immunotherapy by Prasanna, Thiru, Wu, Fan, Khanna, Kum Kum, Yip, Desmond, Malik, Laeeq, Dahlstrom, Jane E., Rao, Sudha

“…Triple‐negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor survival outcomes. Currently, there are no targeted therapies available…”
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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer by Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., Pearson, Richard B.

“…Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cancer (HGSOC). Here, we…”
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Chromosome arm aneuploidies shape tumour evolution and drug response by Shukla, Ankit, Nguyen, Thu H. M., Moka, Sarat B., Ellis, Jonathan J., Grady, John P., Oey, Harald, Cristino, Alexandre S., Khanna, Kum Kum, Kroese, Dirk P., Krause, Lutz, Dray, Eloise, Fink, J. Lynn, Duijf, Pascal H. G.

“…Chromosome arm aneuploidies (CAAs) are pervasive in cancers. However, how they affect cancer development, prognosis and treatment remains largely unknown…”
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The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin by Kalousi, Alkmini, Hoffbeck, Anne-Sophie, Selemenakis, Platonas N., Pinder, Jordan, Savage, Kienan I., Khanna, Kum Kum, Brino, Laurent, Dellaire, Graham, Gorgoulis, Vassilis G., Soutoglou, Evi

“…Cells experience damage from exogenous and endogenous sources that endanger genome stability. Several cellular pathways have evolved to detect DNA damage and…”
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Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma by Ferrari de Andrade, Lucas, Ngiow, Shin F, Stannard, Kimberley, Rusakiewicz, Sylvie, Kalimutho, Murugan, Khanna, Kum Kum, Tey, Siok-Keen, Takeda, Kazuyoshi, Zitvogel, Laurence, Martinet, Ludovic, Smyth, Mark J

“…BRAF(V600E) is a major oncogenic mutation found in approximately 50% of human melanoma that confers constitutive activation of the MAPK pathway and increased…”
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Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1 by Wu, Juan, Zhang, Xian, Zhang, Ling, Wu, Ching-Yuan, Rezaeian, Abdol Hossein, Chan, Chia-Hsin, Li, Ju-Mei, Wang, Jing, Gao, Yuan, Han, Fei, Jeong, Yun Seong, Yuan, Xiandao, Khanna, Kum Kum, Jin, Jianping, Zeng, Yi-Xin, Lin, Hui-Kuan

“…The Mre11/Rad50/NBS1 (MRN) complex is thought to be a critical sensor that detects damaged DNA and recruits ATM to DNA foci for activation. However, it remains…”
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Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair by BOLDERSON, Emma, RICHARD, Derek J, ZHOU, Bin-Bing S, KHANNA, Kum Kum

“…Damage to genetic material represents a persistent and ubiquitous threat to genomic stability. Once DNA damage is detected, a multifaceted signaling network is…”
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