Search Results - "Kulur, Vrishika"
-
1
Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis
Published in Cell reports (Cambridge) (27-03-2018)“…Fibroblast heterogeneity has long been recognized in mouse and human lungs, homeostasis, and disease states. However, there is no common consensus on…”
Get full text
Journal Article -
2
The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis
Published in The Journal of clinical investigation (01-06-2022)“…Type 2 alveolar epithelial cells (AEC2s) function as progenitor cells in the lung. We have shown previously that failure of AEC2 regeneration results in…”
Get full text
Journal Article -
3
Innate Recognition of the Microbiota by TLR1 Promotes Epithelial Homeostasis and Prevents Chronic Inflammation
Published in The Journal of immunology (1950) (01-07-2018)“…There is cross-talk between the intestinal epithelium and the microbiota that functions to maintain a tightly regulated microenvironment and prevent chronic…”
Get full text
Journal Article -
4
PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis
Published in JCI insight (21-03-2019)“…Idiopathic pulmonary fibrosis (IPF) is a progressive disease with unremitting extracellular matrix deposition, leading to a distortion of pulmonary…”
Get full text
Journal Article -
5
Lipid Deficiency Contributes to Impaired Alveolar Progenitor Cell Function in Aging and Idiopathic Pulmonary Fibrosis
Published in American journal of respiratory cell and molecular biology (01-08-2024)“…Idiopathic pulmonary fibrosis (IPF) is an aging-associated interstitial lung disease resulting from repeated epithelial injury and inadequate epithelial…”
Get more information
Journal Article -
6
MicroRNA-29c Prevents Pulmonary Fibrosis by Regulating Epithelial Cell Renewal and Apoptosis
Published in American journal of respiratory cell and molecular biology (01-12-2017)“…Successful repair and renewal of alveolar epithelial cells (AECs) are critical in prohibiting the accumulation of myofibroblasts in pulmonary fibrogenesis…”
Get full text
Journal Article -
7
HER2 drives lung fibrosis by activating a metastatic cancer signature in invasive lung fibroblasts
Published in The Journal of experimental medicine (03-10-2022)“…Progressive tissue fibrosis, including idiopathic pulmonary fibrosis (IPF), is characterized by excessive recruitment of fibroblasts to sites of tissue injury…”
Get full text
Journal Article -
8
Innate recognition of the microbiota by Toll-like Receptor-1 promotes epithelial homeostasis and prevents chronic inflammation
Published in The Journal of immunology (1950) (23-05-2018)“…There is crosstalk between the intestinal epithelium and the microbiota that functions to maintain a tightly regulated microenvironment and prevent chronic…”
Get full text
Journal Article -
9
Mesenchymal growth hormone receptor deficiency leads to failure of alveolar progenitor cell function and severe pulmonary fibrosis
Published in Science advances (01-06-2021)“…Recent studies have identified impaired type 2 alveolar epithelial cell (ATII) renewal in idiopathic pulmonary fibrosis (IPF) human organoids and severe…”
Get full text
Journal Article -
10
Endogenous TLR1 Signaling Controls Intestinal Inflammation
Published 01-01-2015“…The intestine is a complex organ containing multiple but adjacent compartments. The microbial compartment contains 100 trillion commensal bacteria and is…”
Get full text
Dissertation