Search Results - "Kulpa, Jerzy E."

Cardiomyocyte ATP Production, Metabolic Flexibility, and Survival Require Calcium Flux through Cardiac Ryanodine Receptors in Vivo by Bround, Michael J., Wambolt, Rich, Luciani, Dan S., Kulpa, Jerzy E., Rodrigues, Brian, Brownsey, Roger W., Allard, Michael F., Johnson, James D.

“…Ca2+ fluxes between adjacent organelles are thought to control many cellular processes, including metabolism and cell survival. In vitro evidence has been…”
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ATP-Citrate Lyase Reduction Mediates Palmitate-induced Apoptosis in Pancreatic Beta Cells by Chu, Kwan Yi, Lin, Yalin, Hendel, Alon, Kulpa, Jerzy E., Brownsey, Roger W., Johnson, James D.

“…Elevated extracellular lipids, such as the free fatty acid palmitate, can induce pancreatic beta cell endoplasmic reticulum (ER) stress and apoptosis, thereby…”
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Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol by Denroche, Heather C., Kwon, Michelle M., Quong, Whitney L., Neumann, Ursula H., Kulpa, Jerzy E., Karunakaran, Subashini, Clee, Susanne M., Brownsey, Roger W., Covey, Scott D., Kieffer, Timothy J.

“…Aims/hypothesis Leptin has profound glucose-lowering effects in rodent models of type 1 diabetes, and is currently being tested clinically to treat this…”
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Inhibition of Sebum Production with the Acetyl Coenzyme A Carboxylase Inhibitor Olumacostat Glasaretil by Hunt, David W., Winters, Geoffrey C., Brownsey, Roger W., Kulpa, Jerzy E., Gilliland, Kathryn L., Thiboutot, Diane M., Hofland, Hans E.

“…Olumacostat glasaretil (OG) is a small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC), the enzyme that controls the first rate-limiting step…”
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Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase by Bround, Michael J., Wambolt, Rich, Cen, Haoning, Asghari, Parisa, Albu, Razvan F., Han, Jun, McAfee, Donald, Pourrier, Marc, Scott, Nichollas E., Bohunek, Lubos, Kulpa, Jerzy E., Chen, S. R. Wayne, Fedida, David, Brownsey, Roger W., Borchers, Christoph H., Foster, Leonard J., Mayor, Thibault, Moore, Edwin D.W., Allard, Michael F., Johnson, James D.

“…Cardiac ryanodine receptor (Ryr2) Ca2+ release channels and cellular metabolism are both disrupted in heart disease. Recently, we demonstrated that total loss…”
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Acute Cardiac Ryanodine Receptor Loss-of-Function Leads to Cardiomyopathy and Metabolic Dysfunction: Implications for Diabetes Complications by Bround, Michael J, Asghari, Parisa, Wambolt, Rich, Bohunek, Lubos, Luciani, Dan S, Taghizadeh, Farnaz, Kulpa, Jerzy E, Boheler, Kenneth R, Rodrigues, Brian, Brownsey, Roger W, Moore, Edwin D.W, Allard, Michael F, Johnson, James D

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Bimodal Activation of Acetyl-CoA Carboxylase by Glutamate by Boone, Adrienne N., Chan, Andy, Kulpa, Jerzy E., Brownsey, Roger W.

“…Acetyl-CoA carboxylase (ACC) catalyzes the formation of malonyl-CoA, an essential substrate for fatty acid biosynthesis and a potent inhibitor of fatty acid…”
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Mitochondrial proteome of the pressure‐overload hypertrophied rat heart by Brownsey, Roger William, Parsons, Hannah L., Kulpa, Jerzy E., Allard, Michael F.

“…Abstract only Cardiac hypertrophy induced by prolonged hemodynamic overload, leads to changes in myocardial energy metabolism including an acceleration of…”
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Effects of streptozotocin‐induced diabetes on the expression of cardiac mitochondrial proteins revealed by proteomic analysis by Brownsey, Roger William, Kulpa, Jerzy E., Yuen, Violet, McNeill, John H.

“…Streptozotocin (STZ) induces insulin deficiency and profound changes in energy metabolism. Previous studies have addressed changes in specific enzyme…”
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