Search Results - "Kulman, J. D."

Biochemical and functional characterization of a recombinant monomeric factor VIII–Fc fusion protein by PETERS, R. T., TOBY, G., LU, Q., LIU, T., KULMAN, J. D., LOW, S. C., BITONTI, A. J., PIERCE, G. F.

“…Background: Hemophilia A results from a deficiency in factor VIII activity. Current treatment regimens require frequent dosing, owing to the short half‐life of…”
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Identification of Two Novel Transmembrane γ-Carboxyglutamic Acid Proteins Expressed Broadly in Fetal and Adult Tissues by Kulman, John D., Harris, Jeff E., Xie, Ling, Davie, Earl W.

“…The proline-rich γ-carboxyglutamic acid (Gla) proteins (PRGPs) 1 and 2 are the founding members of a family of vitamin K-dependent single-pass integral…”
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A rapid enzyme‐linked assay for ADAMTS‐13 by WU, J.‐J, FUJIKAWA, K., LIAN, E. C., McMULLEN, B. A., KULMAN, J. D., CHUNG, D. W.

“…Background: A deficiency in the plasma metalloprotease ADAMTS‐13 is associated with deposition of microvascular thrombi that cause thrombotic thrombocytopenic…”
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The structural basis for the functional comparability of factor VIII and the long‐acting variant recombinant factor VIII Fc fusion protein by Leksa, N. C., Chiu, P.‐L., Bou‐Assaf, G. M., Quan, C., Liu, Z., Goodman, A. B., Chambers, M. G., Tsutakawa, S. E., Hammel, M., Peters, R. T., Walz, T., Kulman, J. D.

“…Essentials Recombinant factor VIII (rFVIII) Fc fusion protein has a 1.5‐fold longer half‐life than rFVIII. Five orthogonal methods were used to characterize…”
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Primary Structure and Tissue Distribution of Two Novel Proline-Rich γ -carboxyglutamic Acid Proteins by Kulman, John D., Harris, Jeff E., Haldeman, Betty A., Davie, Earl W.

“…Two human cDNAs that encode novel vitamin K-dependent proteins have been cloned and sequenced. The predicted amino acid sequences suggest that both are…”
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The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein by Leksa, N. C., Chiu, P. -L., Bou-Assaf, G. M., Quan, C., Liu, Z., Goodman, A. B., Chambers, M. G., Tsutakawa, S. E., Hammel, M., Peters, R. T., Walz, T., Kulman, J. D.

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A hetero-dimer model for concerted action of vitamin K carboxylase and vitamin K reductase in vitamin K cycle by Wu, Sangwook, Liu, Shubin, Davis, Charles H., Stafford, Darrel W., Kulman, John D., Pedersen, Lee G.

“…Vitamin K carboxylase (VKC) is believed to convert vitamin K, in the vitamin K cycle, to an alkoxide–epoxide form which then reacts with CO 2 and glutamate to…”
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Unraveling thrombin's true microglia‐activating potential: markedly disparate profiles of pharmaceutical‐grade and commercial‐grade thrombin preparations by Weinstein, Jonathan R., Hong, Soyon, Kulman, John D., Bishop, Caroline, Kuniyoshi, Jon, Andersen, Henrik, Ransom, Bruce R., Hanisch, Uwe‐Karsten, Möller, Thomas

“…Microglia are the resident immune cells of the CNS. Brain injury triggers microglial activation, leading to proliferation, changes in antigenic profile, NO…”
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