Search Results - "Kullervo Hynynen"

Applications of focused ultrasound in the brain: from thermoablation to drug delivery by Meng, Ying, Hynynen, Kullervo, Lipsman, Nir

“…Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the clinic represents the culmination of decades of research. Lying at…”
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Ultrasound for drug and gene delivery to the brain by Hynynen, Kullervo

“…Noninvasive, transient, and local image-guided blood-brain barrier disruption (BBBD) has been demonstrated with focused ultrasound exposure in animal models…”
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Ultrasound neuromodulation - principles and cellular mechanisms by Hynynen, Kullervo

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Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose by McMahon, Dallan, Hynynen, Kullervo

“…Focused ultrasound (FUS), in conjunction with circulating microbubbles (MBs), can be used to transiently increase the permeability of the blood-brain barrier…”
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MRIgHIFU: A tool for image-guided therapeutics by Hynynen, Kullervo

“…High‐intensity focused ultrasound (HIFU) provides focal delivery of mechanical energy deep into the body. This energy can be used to elevate the tissue…”
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Drug delivery across the blood-brain barrier using focused ultrasound by Burgess, Alison, Hynynen, Kullervo

“…The presence of the blood-brain barrier (BBB) is a significant impediment to the delivery of therapeutic agents to the brain for treatment of brain diseases…”
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Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study by Mainprize, Todd, Lipsman, Nir, Huang, Yuexi, Meng, Ying, Bethune, Allison, Ironside, Sarah, Heyn, Chinthaka, Alkins, Ryan, Trudeau, Maureen, Sahgal, Arjun, Perry, James, Hynynen, Kullervo

“…The blood-brain barrier (BBB) has long limited therapeutic access to brain tumor and peritumoral tissue. In animals, MR-guided focused ultrasound (MRgFUS) with…”
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Focused ultrasound-mediated drug delivery through the blood-brain barrier by Burgess, Alison, Shah, Kairavi, Hough, Olivia, Hynynen, Kullervo

“…Despite recent advances in blood-brain barrier (BBB) research, it remains a significant hurdle for the pharmaceutical treatment of brain diseases. Focused…”
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Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome by McMahon, Dallan, Bendayan, Reina, Hynynen, Kullervo

“…Therapeutic treatment options for central nervous system diseases are greatly limited by the blood-brain barrier (BBB). Focused ultrasound (FUS), in…”
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Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound by Lipsman, Nir, Meng, Ying, Bethune, Allison J., Huang, Yuexi, Lam, Benjamin, Masellis, Mario, Herrmann, Nathan, Heyn, Chinthaka, Aubert, Isabelle, Boutet, Alexandre, Smith, Gwenn S., Hynynen, Kullervo, Black, Sandra E.

“…Magnetic resonance-guided focused ultrasound in combination with intravenously injected microbubbles has been shown to transiently open the blood–brain…”
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MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study by Lipsman, Nir, MD, Schwartz, Michael L, Prof, Huang, Yuexi, PhD, Lee, Liesly, MD, Sankar, Tejas, MD, Chapman, Martin, MD, Hynynen, Kullervo, Prof, Lozano, Andres M, Prof

“…Summary Background Essential tremor is the most common movement disorder and is often refractory to medical treatment. Surgical therapies, using lesioning and…”
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First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound by Abrahao, Agessandro, Meng, Ying, Llinas, Maheleth, Huang, Yuexi, Hamani, Clement, Mainprize, Todd, Aubert, Isabelle, Heyn, Chinthaka, Black, Sandra E., Hynynen, Kullervo, Lipsman, Nir, Zinman, Lorne

“…MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately and transiently permeabilize the blood-brain barrier (BBB) for targeted…”
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Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior by Burgess, Alison, Dubey, Sonam, Yeung, Sharon, Hough, Olivia, Eterman, Naomi, Aubert, Isabelle, Hynynen, Kullervo

“…To validate whether repeated magnetic resonance (MR) imaging-guided focused ultrasound treatments targeted to the hippocampus, a brain structure relevant for…”
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Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability by McMahon, Dallan, Poon, Charissa, Hynynen, Kullervo

“…Treatment of several diseases of the brain are complicated by the presence of the skull and the blood-brain barrier (BBB). Focused ultrasound (FUS) and…”
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Microbubble formulation influences inflammatory response to focused ultrasound exposure in the brain by McMahon, Dallan, Lassus, Anne, Gaud, Emmanuel, Jeannot, Victor, Hynynen, Kullervo

“…Focused ultrasound and microbubble (FUS + MB)-mediated blood–brain barrier (BBB) permeability enhancement can facilitate targeted brain-drug delivery. While…”
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Multi-frequency characterization of the speed of sound and attenuation coefficient for longitudinal transmission of freshly excised human skulls by Pichardo, Samuel, Sin, Vivian W, Hynynen, Kullervo

“…For medical applications of ultrasound inside the brain, it is necessary to understand the relationship between the apparent density of skull bone and its…”
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Hyperthermia-induced drug delivery in humans by Hynynen, Kullervo

“…A clinical study shows the feasibility and safety of the intratumoral release of an anticancer drug encapsulated in thermosensitive liposomes by heating the…”
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Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma by Treat, Lisa H, McDannold, Nathan, Zhang, Yongzhi, Vykhodtseva, Natalia, Hynynen, Kullervo

“…Abstract The blood-brain barrier (BBB) inhibits the entry of the majority of chemotherapeutic agents into the brain. Previous studies have illustrated the…”
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Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability by Jones, Ryan M, Hynynen, Kullervo

“…Transcranial focused ultrasound (FUS) combined with intravenously circulating microbubbles can transiently and selectively increase blood-brain barrier…”
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Numerical simulations of clinical focused ultrasound functional neurosurgery by Pulkkinen, Aki, Werner, Beat, Martin, Ernst, Hynynen, Kullervo

“…A computational model utilizing grid and finite difference methods were developed to simulate focused ultrasound functional neurosurgery interventions. The…”
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