Search Results - "Kulkarni, Vineet"

Novel 3D Printed Modular Tablets Containing Multiple Anti-Viral Drugs: a Case of High Precision Drop-on-Demand Drug Deposition by Lu, Anqi, Zhang, Jiaxiang, Jiang, Junhuang, Zhang, Yu, Giri, Bhupendra R., Kulkarni, Vineet R., Aghda, Niloofar Heshmati, Wang, Jiawei, Maniruzzaman, Mohammed

“…3D printed drug delivery systems have gained tremendous attention in pharmaceutical research due to their inherent benefits over conventional systems, such as…”
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Single-Step Extrusion Process for Formulation Development of Self-Emulsifying Granules for Oral Delivery of a BCS Class IV Drug by Kulkarni, Vineet R, Bashyal, Santosh, Nair, Varsha V, Duggal, Ishaan, Maniruzzaman, Mohammed

“…This study aimed to develop and optimize formulations containinga BCS Class IV drug by improving its solubility and permeability. Herein development of…”
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Investigation of the Fused Deposition Modeling Additive Manufacturing I: Influence of Process Temperature on the Quality and Crystallinity of the Dosage Forms by Zhang, Jiaxiang, Thakkar, Rishi, Kulkarni, Vineet R., Zhang, Yu, Lu, Anqi, Maniruzzaman, Mohammed

“…With the advancements in cutting-edge technologies and rapid development of medical sciences, patient-focused drug development (PFDD) through additive…”
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Novel On-Demand 3-Dimensional (3-D) Printed Tablets Using Fill Density as an Effective Release-Controlling Tool by Thakkar, Rishi, Pillai, Amit Raviraj, Zhang, Jiaxiang, Zhang, Yu, Kulkarni, Vineet, Maniruzzaman, Mohammed

“…This research demonstrates the use of fill density as an effective tool for controlling the drug release without changing the formulation composition. The…”
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Veering to a Continuous Platform of Fused Deposition Modeling Based 3D Printing for Pharmaceutical Dosage Forms: Understanding the Effect of Layer Orientation on Formulation Performance by Kulkarni, Vineet R, Chakka, Jaidev, Alkadi, Faez, Maniruzzaman, Mohammed

“…Three-dimensional (3D) printing of pharmaceuticals has been centered around the idea of personalized patient-based 'on-demand' medication. Fused deposition…”
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Advancements in Ocular Therapy: A Review of Emerging Drug Delivery Approaches and Pharmaceutical Technologies by Giri, Bhupendra Raj, Jakka, Deeksha, Sandoval, Michael A, Kulkarni, Vineet R, Bao, Quanying

“…Eye disorders affect a substantial portion of the global population, yet the availability of efficacious ophthalmic drug products remains limited. This can be…”
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Three-Dimensional Printing of a Container Tablet: A New Paradigm for Multi-Drug-Containing Bioactive Self-Nanoemulsifying Drug-Delivery Systems (Bio-SNEDDSs) by Kulkarni, Vineet R, Kazi, Mohsin, Shahba, Ahmad Abdul-Wahhab, Radhanpuri, Aakib, Maniruzzaman, Mohammed

“…This research demonstrates the use of fused deposition modeling (FDM) 3D printing to control the delivery of multiple drugs containing bioactive self-nano…”
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SM protein Munc18-2 facilitates transition of Syntaxin 11-mediated lipid mixing to complete fusion for T-lymphocyte cytotoxicity by Spessott, Waldo A., Sanmillan, Maria L., McCormick, Margaret E., Kulkarni, Vineet V., Giraudo, Claudio G.

“…The atypical lipid-anchored Syntaxin 11 (STX11) and its binding partner, the Sec/Munc (SM) protein Munc18-2, facilitate cytolytic granule release by cytotoxic…”
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Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles during Dissolution by Jara, Miguel O, Warnken, Zachary N, Sahakijpijarn, Sawittree, Thakkar, Rishi, Kulkarni, Vineet R, Christensen, Dale J, Koleng, John J, Williams, 3rd, Robert O

“…Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several…”
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Syntaxin 4 mediates endosome recycling for lytic granule exocytosis in cytotoxic T‐lymphocytes by Spessott, Waldo A., Sanmillan, Maria L., Kulkarni, Vineet V., McCormick, Margaret E., Giraudo, Claudio G.

“…Adaptive and innate immunity utilize the perforin‐killing pathway to eliminate virus‐infected or cancer cells. Cytotoxic T‐lymphocytes (CTLs) and natural…”
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Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons by Kulkarni, Vineet Vinay, Maday, Sandra

“…Macroautophagy (hereafter autophagy) and endocytic trafficking are key pathways in neuronal axons that regulate the composition and integrity of the axonal…”
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Association between LPA rs6415084 and rs6919346 variants and serum lipoprotein(a) levels amongst apparently healthy individuals by Roby, Dyna, Bhandary, Roopa, Shetty, Sukanya, Kulkarni, Vineet, Roby, Calvin

“…Introduction: Lipoprotein(a) (Lp[a]) synthesised by the liver consists of low-density lipoprotein which contains apoB-100 linked to apolipoprotein(a) (apo[a])…”
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Correlation of serum lipoprotein (a) levels with angiographic lesion severity in coronary artery disease by Vineet Kulkarni, Sukanya Shetty, K Subramanya, Anirban Chakraborty, Prakash Patil, Roopa Bhandary, Rashmi Kundapur

“…Background: The several epidemiological and meta-analysis studies suggested that the elevated lipoprotein (a) (Lp(a)) level is associated to cause the coronary…”
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Compartment‐specific dynamics and functions of autophagy in neurons by Kulkarni, Vineet Vinay, Maday, Sandra

“…ABSTRACT Autophagy is a lysosomal degradation pathway that is critical to maintaining neuronal homeostasis and viability. Autophagy sequesters damaged and aged…”
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Therapeutic implications of nanomedicine for ocular drug delivery by Meng, Tuo, Kulkarni, Vineet, Simmers, Russell, Brar, Vikram, Xu, Qingguo

“…•Ocular nanomedicine with great clinical translational potential.•Nanomedicine can be used for treating anterior and posterior eye diseases.•The principles of…”
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Synaptic activity controls autophagic vacuole motility and function in dendrites by Kulkarni, Vineet Vinay, Anand, Anip, Herr, Jessica Brandt, Miranda, Christina, Vogel, Maria Chalokh, Maday, Sandra

“…Macroautophagy (hereafter "autophagy") is a lysosomal degradation pathway that is important for learning and memory, suggesting critical roles for autophagy at…”
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Differential regulation of autophagy during metabolic stress in astrocytes and neurons by Kulkarni, Aditi, Dong, Audrey, Kulkarni, Vineet Vinay, Chen, Jessica, Laxton, Olivia, Anand, Anip, Maday, Sandra

“…Macroautophagy/autophagy is a key homeostatic process that targets cytoplasmic components to the lysosome for breakdown and recycling. Autophagy plays critical…”
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Methods for Imaging Autophagosome Dynamics in Primary Neurons by Dong, Audrey, Kulkarni, Vineet Vinay, Maday, Sandra

“…Autophagy is an essential degradative pathway that maintains neuronal homeostasis and prevents axon degeneration. However, the mechanisms of autophagy in…”
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Retrograde Axonal Autophagy and Endocytic Pathways Are Parallel and Separate in Neurons by Kulkarni, Vineet Vinay, Stempel, Max Henry, Anand, Anip, Sidibe, David Kader, Maday, Sandra

“…Autophagy and endocytic trafficking are two key pathways that regulate the composition and integrity of the neuronal proteome. Alterations in these pathways…”
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Neuronal endosomes to lysosomes: A journey to the soma by Kulkarni, Vineet Vinay, Maday, Sandra

“…How are lysosomal degradation pathways spatially organized in the complex landscape of a neuron? Cheng et al. (2018. https://doi.org/10.1083/jcb.201711083) and…”
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