Search Results - "Kulkarni, Shardul D."

eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide by Zhou, Fujun, Zhang, Hongen, Kulkarni, Shardul D, Lorsch, Jon R, Hinnebusch, Alan G

“…The translation preinitiation complex (PIC) scans the mRNA for an AUG codon in a favorable context. Previous findings suggest that the factor eIF1…”
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Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae by Kulkarni, Shardul D, Zhou, Fujun, Sen, Neelam Dabas, Zhang, Hongen, Hinnebusch, Alan G, Lorsch, Jon R

“…Translation of an mRNA in eukaryotes starts at an AUG codon in most cases, but near-cognate codons (NCCs) such as UUG, ACG, and AUU can also be used as start…”
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eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast by Martin-Marcos, Pilar, Zhou, Fujun, Karunasiri, Charm, Zhang, Fan, Dong, Jinsheng, Nanda, Jagpreet, Kulkarni, Shardul D, Sen, Neelam Dabas, Tamame, Mercedes, Zeschnigk, Michael, Lorsch, Jon R, Hinnebusch, Alan G

“…The translation pre-initiation complex (PIC) scans the mRNA for an AUG codon in favorable context, and AUG recognition stabilizes a closed PIC conformation…”
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miR-196b-Mediated Translation Regulation of Mouse Insulin2 via the 5′UTR by Panda, Amaresh C., Sahu, Itishri, Kulkarni, Shardul D., Martindale, Jennifer L., Abdelmohsen, Kotb, Vindu, Arya, Joseph, Jomon, Gorospe, Myriam, Seshadri, Vasudevan

“…The 5′ and the 3′ untranslated regions (UTR) of the insulin genes are very well conserved across species. Although microRNAs (miRNAs) are known to regulate…”
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Corrigendum: eIF3 and Its mRNA-Entry-Channel Arm Contribute to the Recruitment of mRNAs With Long 5′-Untranslated Regions by Stanciu, Andrei, Luo, Juncheng, Funes, Lucy, Galbokke Hewage, Shanya, Kulkarni, Shardul D., Aitken, Colin Echeverría

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Glucose-stimulated Translation Regulation of Insulin by the 5′ UTR-binding Proteins by Kulkarni, Shardul D., Muralidharan, Bhavana, Panda, Amaresh C., Bakthavachalu, Baskar, Vindu, Arya, Seshadri, Vasudevan

“…Insulin is the key regulator of glucose homeostasis in mammals, and glucose-stimulated insulin biosynthesis is essential for maintaining glucose levels in a…”
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Novel splice variant of mouse insulin2 mRNA: Implications for insulin expression by Panda, Amaresh C., Kulkarni, Shardul D., Muralidharan, Bhavana, Bakthavachalu, Baskar, Seshadri, Vasudevan

“…Insulin is a secreted peptide that controls glucose homeostasis in mammals, and insulin biosynthesis is regulated by glucose at many levels. Rodent insulin is…”
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Translation of insulin granule proteins are regulated by PDI and PABP by Sarwade, Rucha D., Khalique, Abdul, Kulkarni, Shardul D., Pandey, Poonam R., Gaikwad, Naina, Seshadri, Vasudevan

“…Glucose mediated insulin biosynthesis is tightly regulated and shared between insulin granule proteins such as its processing enzymes, prohormone convertases,…”
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eIF3 and Its mRNA-Entry-Channel Arm Contribute to the Recruitment of mRNAs With Long 5'-Untranslated Regions by Stanciu, Andrei, Luo, Juncheng, Funes, Lucy, Galbokke Hewage, Shanya, Aitken, Colin Echeverría

“…Translation initiation in eukaryotes is a multi-step pathway and the most regulated phase of translation. Eukaryotic initiation factor 3 (eIF3) is the largest…”
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miR-196b-mediated translation regulation of mouse insulin2 via the 5'UTR by Panda, Amaresh C, Sahu, Itishri, Kulkarni, Shardul D, Martindale, Jennifer L, Abdelmohsen, Kotb, Vindu, Arya, Joseph, Jomon, Gorospe, Myriam, Seshadri, Vasudevan

“…The 5' and the 3' untranslated regions (UTR) of the insulin genes are very well conserved across species. Although microRNAs (miRNAs) are known to regulate…”
Get full text