Flavanones and Chromones from Salicornia herbacea Mitigate Septic Lethality via Restoration of Vascular Barrier Integrity

Salicornia herbacea is an annual halophytic glasswort that has been employed as a culinary vegetable, salad, and traditional medicinal resource. Chemical investigation of the aerial parts of S. herbacea led to the isolation of two new (1, 2) and known (3) flavanones as well as a new nature-derived (...

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Bibliographic Details
Published in:	Journal of agricultural and food chemistry Vol. 63; no. 46; pp. 10121 - 10130
Main Authors:	Tuan, Nguyen Quoc, Lee, Wonhwa, Oh, Joonseok, Kulkarni, Roshan Rajan, Gény, Charlotte, Jung, Byeongjin, Kang, Hyejin, Bae, Jong-Sup, Na, MinKyun
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 25-11-2015
Subjects:	Animals Cecum - surgery Chenopodiaceae - chemistry Chromones - isolation & purification Chromones - therapeutic use Disease Models, Animal Endothelium, Vascular - drug effects Flavanones - isolation & purification Flavanones - therapeutic use HMGB1 Protein - antagonists & inhibitors HMGB1 Protein - physiology Human Umbilical Vein Endothelial Cells Lipopolysaccharides - pharmacology Male Mice Mice, Inbred C57BL Phytotherapy Plant Components, Aerial - chemistry Sepsis - drug therapy Shock, Septic - drug therapy severe sepsis. endothelial barrier integrity high mobility group box 1 protein chromones Salicornia herbacea flavanones
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Summary:	Salicornia herbacea is an annual halophytic glasswort that has been employed as a culinary vegetable, salad, and traditional medicinal resource. Chemical investigation of the aerial parts of S. herbacea led to the isolation of two new (1, 2) and known (3) flavanones as well as a new nature-derived (4) and two known chromone derivatives (5, 6). These purified compounds were evaluated for their suppressive potentials against the release of high-mobility group box 1 protein (HMGB1), which has captured attention as a viable target for alleviating serious septic manifestations or septicemia. The phenolic compounds improved the survival rates of cecal ligation and puncture operation (CLP) in murine models, simulating severe septic shock and its related complications, to 40–60%. These results collectively validate that flavanone- and chromone-based secondary metabolites may serve as prospective prodrugs or food additives that may be commercialized for the control of septic complications and lethality.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-8561 1520-5118
DOI:	10.1021/acs.jafc.5b04069